Universals, Laws, and Governance

Proponents of the dispositional theory of properties typically claim that their view is not one that offers a realist, governing conception of laws. My first aim is to show that, contrary to this claim, if one commits to dispositionalism then one does not automatically give up on a robust, realist theory of laws. This is because dispositionalism can readily be developed within a Platonic framework of universals. Second, I argue that there are good reasons for realist dispositionalists to favour a Platonic view. This is because the alternative Aristotelian version of dispositionalism, on which universals are immanent entities, is unstable for various reasons. My final aim is to address a common criticism facing Platonic theories of laws, which is the problem of how external entities can play an explanatory role where the world’s law-like patterns of behaviour are concerned. I argue that the Platonists’ response to the one over many problem can help to shed light on this matter, and a possible solution is sketched, one which makes use of the notions of essence, constitution and ontological dependence

Custom design of protein particles as multifunctional biomaterials

Assembled protein particles, as emerging biomaterials, have broad applications ranging from vaccines and drug delivery to biocatalysis and particle tracking, but to date these require trial-and-error rational design experimentation and/or intensive computational methods to generate. Here, the authors describe an easy-to-implement engineering strategy to generate customized protein particles as multifunctional biomaterials. They utilize protein–peptide modules to generate functional nanoparticles whose assembly and size is controlled by the addition of mild stimuli. The protein assembling method is versatile, as exemplified through particle formation with 7 distinct protein modules, using a variety of assembly conditions tailored by the chemistries of 3 peptide partners. They have generated customized protein particles using enzymes, binding and reporter proteins, and their functions and utilities are demonstrated using biocatalysis, sensing, and labelling applications, respectively. Furthermore, co-assembly with two functional proteins within one particle has been successfully achieved and demonstrated. Physical insights into the kinetics and molecular mechanisms of particle formation are revealed by small angle X-ray scattering and mass photometry, providing fundamental knowledge to guide design and manufacture these interesting biomaterials in future. Their protein assembling strategy is a reliable method for fabricating a protein particle to deliver new functionalities on-demand

Metaphysics as the First Philosophy

Aristotle talks about 'the first philosophy' throughout the Metaphysics – and it is metaphysics that Aristotle considers to be the first philosophy – but he never makes it entirely clear what first philosophy consists of. What he does make clear is that the first philosophy is not to be understood as a collection of topics that should be studied in advance of any other topics. In fact, Aristotle seems to have thought that the topics of Metaphysics are to be studied after those in Physics. In what sense could metaphysics be the first philosophy in the context of contemporary metaphysics? This is the question examined in this essay. Contemporary topics such as fundamentality, grounding, and ontological dependence are considered as possible ways to understand the idea of first philosophy, but I will argue that the best way to understand it is in terms of essence