77 research outputs found
Effective intraparticle diffusion coefficients of CoCl2 in mesoporous functionalized silica adsorbents
The scope of this work is to determine the effective intraparticle diffusion coefficient of CoCl2 over mesoporous functionalized silica. Silica is selected as a carrier of the functionalized groups for its rigid structure which excludes troublesome swelling, often found in polymeric adsorbents. 2-(2-pyridyl)ethyl-functionalized silica is selected as a promising affinity adsorbent for the reversible adsorption of CoCl2. The adsorption kinetics is investigated with the Zero Length Column (ZLC) method. Initially, experiments were performed at different flow rates to eliminate the effect of external mass transfer. The effect of pore size (60 Å and 90 Å), particle size (40⋅10−6 m–1000⋅10−6 m) and initial CoCl2 concentration (1 mol/m3–2.0 mol/m3) on the mass transfer was investigated. A model was developed to determine the pore diffusion coefficient of CoCl2 by fitting the experimental data to the model. The pore diffusion coefficients determined for two different pore sizes of silica are D p (60 Å) =1.95⋅10−10 [m2/s] and D p (90 Å) =5.8⋅10−10 [m2/s]. The particle size and the initial CoCl2 concentration do not have an influence on the value of diffusion coefficient. However, particle size has an influence on the diffusion time constant. In comparison with polymer adsorbents, silica based adsorbents have higher values of diffusion coefficients, as well as a more uniform and stable pore structure
Food safety and environmental risks based on meat and dairy consumption surveys
This paper gives an overview of the possibilities of using meat and dairy consumption studies in food safety and environmental risk scenarios. For both types of risk-based scenarios, common denominators are consumption patterns such as frequency and quantity of consumed food, demographic profile of consumers and food safety hazard or environmental impact of a specific type of food. This type of data enables development of simulation models where the Monte Carlo method is considered as a useful mathematical tool. Synergy of three dimensions - field research used in consumption studies, advanced chemometric tools necessary for quantifying chemical food safety hazards or environmental impacts and simulation models - has the potential to adapt datasets from various sources into useful food safety and/or environmental information
Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities
Chronic obstructive pulmonary disease (COPD) and lung cancer are major lung diseases affecting millions worldwide. Both diseases have links to cigarette smoking and exert a considerable societal burden. People suffering from COPD are at higher risk of developing lung cancer than those without, and are more susceptible to poor outcomes after diagnosis and treatment. Lung cancer and COPD are closely associated, possibly sharing common traits such as an underlying genetic predisposition, epithelial and endothelial cell plasticity, dysfunctional inflammatory mechanisms including the deposition of excessive extracellular matrix, angiogenesis, susceptibility to DNA damage and cellular mutagenesis. In fact, COPD could be the driving factor for lung cancer, providing a conducive environment that propagates its evolution. In the early stages of smoking, body defences provide a combative immune/oxidative response and DNA repair mechanisms are likely to subdue these changes to a certain extent; however, in patients with COPD with lung cancer the consequences could be devastating, potentially contributing to slower postoperative recovery after lung resection and increased resistance to radiotherapy and chemotherapy. Vital to the development of new-targeted therapies is an in-depth understanding of various molecular mechanisms that are associated with both pathologies. In this comprehensive review, we provide a detailed overview of possible underlying factors that link COPD and lung cancer, and current therapeutic advances from both human and preclinical animal models that can effectively mitigate this unholy relationship
Enhancement strategies for transdermal drug delivery systems: current trends and applications
Development of nanotechnology-based drug delivery systems with olive vegetable oil for cutaneous application
Reverse Flow Adsorption Technology for the Process Integrated Recycling of Homogeneous Catalyst
Reverse Flow Adsorption Technology for the Process Integrated Recycling of Homogeneous Catalyst
Reverse Flow Adsorption Technology for the Process Integrated Recycling of Homogeneous Catalyst
Reverse Flow Adsorption Technology for the Process Integrated Recycling of Homogeneous Catalyst
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