Laser-assisted fabrication and in vitro verification of functionalized surface for cells biointegration

The paper investigates how the surface relief of an implant affects cell behavior. Currently, most implant manufacturers claim the key impact biocompatibility factor to be surface micro-roughness. We suppose that the interaction between cells and implants also depends on such relief peculiarities as continuous or discontinuous topography, subcellular distance between peaks and presence of porous oxide layer. We have developed the laser processing conditions that provide three different reliefs: "open grooves", "grid" and "close grooves". Along with the micro-roughness characteristics the reliefs differ with their deepness and period of groove

ELECTRONIC STRUCTURE OF FeSi

The full set of high-energy spectroscopy measurements including X-ray photoelectron valence band spectra and soft X-ray emission valence band spectra of both components of FeSi (Fe K_beta_5, Fe L_alpha, Si K_beta_1,3 and Si L_2,3) are performed and compared with the results of ab-initio band structure calculations using the linearized muffin-tin orbital method and linearized augmented plane wave method.Comment: 11 pages + 3 PostScript figures, RevTex3.0, to be published in J.Phys.:Cond.Matte

Genetic insights into the social organization of Neanderthals

Genomic analyses of Neanderthals have previously provided insights into their population history and relationship to modern humans1–8, but the social organization of Neanderthal communities remains poorly understood. Here we present genetic data for 13 Neanderthals from two Middle Palaeolithic sites in the Altai Mountains of southern Siberia: 11 from Chagyrskaya Cave9,10 and 2 from Okladnikov Cave11—making this one of the largest genetic studies of a Neanderthal population to date. We used hybridization capture to obtain genome-wide nuclear data, as well as mitochondrial and Y-chromosome sequences. Some Chagyrskaya individuals were closely related, including a father–daughter pair and a pair of second-degree relatives, indicating that at least some of the individuals lived at the same time. Up to one-third of these individuals’ genomes had long segments of homozygosity, suggesting that the Chagyrskaya Neanderthals were part of a small community. In addition, the Y-chromosome diversity is an order of magnitude lower than the mitochondrial diversity, a pattern that we found is best explained by female migration between communities. Thus, the genetic data presented here provide a detailed documentation of the social organization of an isolated Neanderthal community at the easternmost extent of their known range

Синтез и биологическое действие (±)-транс-2-[2-(диалкиламино)этокси]циклогексанолов и их сложных эфиров

This article is devoted to a method of synthesis and study of the properties of (±) - trans-2-[2-dialkylamino)ethoxy]cyclohexahols and aminoesters. It was found that the studied compounds are not toxic and have expressed antiarrhythmic propertiesСинтезирована серия аминоциклогексанолов и их сложных эфиров с целью выяснения их биологической активности. Показано, что полученные соединения обладают антиаритмической активностью и низкой токсичностью

Синтез, свойства и биологическое действие (±)-транс- 2-диалкиламиноциклогексанолов и их сложных эфиров

A series of trans-2-(substituted amino)-cyclohehyl esters have been synthesized and examined for pharmacological activity. Significant responses have been noted with these compounds as ant arrhythmic substances.Синтезирована серия транс-2-диалкиламиноциклогексанолов и их сложных эфиров с целью выяснения их биологической активности. Показано, что полученные соединения обладают антиаритмической активностью и низкой токсичностью

Synthesis, biological properties and effects of trans-2-(substituted amino)-cyclohehyl esters.

A series of trans-2-(substituted amino)-cyclohehyl esters have been synthesized and examined for pharmacological activity. Significant responses have been noted with these compounds as ant arrhythmic substances

Synthesis and properties of (±)-trans-2- [2-(dialkylamino)ethoxy]cyclohexahols and of their esters

This article is devoted to a method of synthesis and study of the properties of (±) - trans-2-[2-dialkylamino)ethoxy]cyclohexahols and aminoesters. It was found that the studied compounds are not toxic and have expressed antiarrhythmic propertie