Technology transfer - A selected bibliography

Selected bibliography on technology transfe

Alcohol: taking a population perspective

Alcohol consumption is a global phenomenon, as is the resultant health, social and economic harm. The nature of these harms varies with different drinking patterns and with the societal and political responses to the burden of harm; nevertheless, alcohol-related chronic diseases have a major effect on health. Strong evidence exists for the effectiveness of different strategies to minimize this damage and those policies that target price, availability and marketing of alcohol come out best, whereas those using education and information are much less effective. However, these policies can be portrayed as anti-libertarian and so viewing them in the context of alcohol-related harm to those other than the drinker, such as the most vulnerable in society, is important. When this strategy is successful, as in Scotland, it has been possible to pass strong and effective legislation, such as for a minimum unit price for alcohol

Inhibition of oncogenic transcription factor REL by the natural product derivative calafianin monomer 101 induces proliferation arrest and apoptosis in human B-lymphoma cell lines

Increased activity of transcription factor NF-κB has been implicated in many B-cell lymphomas. We investigated effects of synthetic compound calafianin monomer (CM101) on biochemical and biological properties of NF-κB. In human 293 cells, CM101 selectively inhibited DNA binding by overexpressed NF-κB subunits REL (human c-Rel) and p65 as compared to NF-κB p50, and inhibition of REL and p65 DNA binding by CM101 required a conserved cysteine residue. CM101 also inhibited DNA binding by REL in human B-lymphoma cell lines, and the sensitivity of several B-lymphoma cell lines to CM101-induced proliferation arrest and apoptosis correlated with levels of cellular and nuclear REL. CM101 treatment induced both phosphorylation and decreased expression of anti-apoptotic protein Bcl-XL, a REL target gene product, in sensitive B-lymphoma cell lines. Ectopic expression of Bcl-XL protected SUDHL-2 B-lymphoma cells against CM101-induced apoptosis, and overexpression of a transforming mutant of REL decreased the sensitivity of BJAB B-lymphoma cells to CM101-induced apoptosis. Lipopolysaccharide-induced activation of NF-κB signaling upstream components occurred in RAW264.7 macrophages at CM101 concentrations that blocked NF-κB DNA binding. Direct inhibitors of REL may be useful for treating B-cell lymphomas in which REL is active, and may inhibit B-lymphoma cell growth at doses that do not affect some immune-related responses in normal cells.R01 GM094551 - NIGMS NIH HHS; P50 GM067041 - NIGMS NIH HHS; GM094551 - NIGMS NIH HHS; R24 GM111625 - NIGMS NIH HHS; GM067041 - NIGMS NIH HH

Advanced propellant management system for spacecraft propulsion systems. Phase 1 - Survey study and evaluation

Apollo spacecraft propulsion system propellant managemen

The Tamm-Dancoff Approximation as the boson limit of the Richardson-Gaudin equations for pairing

A connection is made between the exact eigen states of the BCS Hamiltonian and the predictions made by the Tamm-Dancoff Approximation. This connection is made by means of a parametrised algebra, which gives the exact quasi-spin algebra in one limit of the parameter and the Heisenberg-Weyl algebra in the other. Using this algebra to construct the Bethe Ansatz solution of the BCS Hamiltonian, we obtain parametrised Richardson-Gaudin equations, leading to the secular equation of the Tamm-Dancoff Approximation in the bosonic limit. An example is discussed in depth.Comment: Submitted to the proceedings of the Group28 conference (Newcastle-upon-Tyne, UK). Journal of Physics: Conference Serie

Evaluating an unconfined aquifer by analysis of age-dating tracers in stream water

The mean transit time (MTT) is a fundamental property of a groundwater flow system that is strongly related to the ratio of recharge rate to storage volume. However, obtaining samples for estimating the MTT using environmental tracers is problematic as flow-weighted samples over the full spectrum of transit times are needed. Samples collected fromthe base flow of a gaining stream in the North Carolina Coastal Plain (West Bear Creek) that were corrected for exchange with the atmosphere yielded environmental tracer concentrations (SF6 and CFC-11) very similar to flow-weighted values from nine or ten streambed piezometers that directly sampled groundwater during low streamflow. At higher streamflow on the falling limb of the hydrograph, stream tracer concentrations (after correction for gas exchange) were significantly higher than the flow-weighted mean from piezometers, consistent with dominance of the streamtracer signal by transient influx of surface water and/or younger subsurface water. The apparent MTT derived from SF6 in low flow stream water samples was 26 years, suggesting a groundwater recharge rate of about 210 mm/yr, that is consistent with vertical profiles obtained by sampling nested piezometers in the aquifer. When sampled under low flow conditions when streamflow consists of a high component of groundwater discharge, West Bear Creek appears to act as a flow-weighted integrator of transit times and, streamflow samples can provide fundamental information regarding groundwater recharge rate and MTT. Our study suggests that watershed-scale evaluation of some groundwater flow systems is possible without utilizing monitoring wells

Modeling the elastic deformation of polymer crusts formed by sessile droplet evaporation

Evaporating droplets of polymer or colloid solution may produce a glassy crust at the liquid-vapour interface, which subsequently deforms as an elastic shell. For sessile droplets, the known radial outward flow of solvent is expected to generate crusts that are thicker near the pinned contact line than the apex. Here we investigate, by non-linear quasi-static simulation and scaling analysis, the deformation mode and stability properties of elastic caps with a non-uniform thickness profile. By suitably scaling the mean thickness and the contact angle between crust and substrate, we find data collapse onto a master curve for both buckling pressure and deformation mode, thus allowing us to predict when the deformed shape is a dimple, mexican hat, and so on. This master curve is parameterised by a dimensionless measure of the non-uniformity of the shell. We also speculate on how overlapping timescales for gelation and deformation may alter our findings.Comment: 8 pages, 7 figs. Some extra clarification of a few points, and minor corrections. To appear in Phys. Rev.

The Absence of Extra-Tidal Structure in the Sculptor Dwarf Spheroidal Galaxy

The results of a wide-field survey of the Sculptor dwarf spheroidal galaxy are presented. Our aims were to obtain an accurate map of the outer structure of Sculptor, and to determine the level of interaction between this system and the Galaxy. Photometry was obtained in two colours down to the magnitude limits of V=20 and I=19, covering a 3.1 times 3.1 square deg area centred on Sculptor. The resulting colour-magnitude data were used as a mask to select candidate horizontal branch and red giant branch stars for this system. Previous work has shown that the red horizontal branch (HB) stars are more concentrated than the blue HB stars. We have determined the radial distributions of these two populations and show that the overall Sculptor density profile is well described by a two component model based on a combination of these radial distributions. Additionally, spectra of the Ca ii triplet region were obtained for over 700 candidate red giant stars over the 10 square deg region using the 2dF instrument on the Anglo-Australian Telescope. These spectra were used to remove foreground Galactic stars based on radial velocity and Ca ii triplet strength. The final list of Sculptor members contained 148 stars, seven of which are located beyond the nominal tidal radius. Both the photometric and spectroscopic datasets indicate no significant extra-tidal structure. These results support at most a mild level of interaction between this system and the Galaxy, and we have measured an upper mass limit for extra-tidal material to be 2.3 +/- 0.6% of the Sculptor luminous mass. This lack of tidal interaction indicates that previous velocity dispersion measurements (and hence the amount of dark matter detected) in this system are not strongly influenced by the Galactic tidal field.Comment: 53 pages, 23 figures. Accepted for publication in the Astronomical Journal. Some figures are reduced in size, and a full version is available at: ftp://ftp.mso.anu.edu.au/pub/coleman/sculptor.pd