Insights into nervous system repair from the fruit fly

Abstract Millions of people experience injury to the central nervous system (CNS) each year, many of whom are left permanently disabled, providing a challenging hurdle for the field of regenerative medicine. Repair of damage in the CNS occurs through a concerted effort of phagocytosis of debris, cell proliferation and differentiation to produce new neurons and glia, distal axon/dendrite degeneration, proximal axon/dendrite regeneration and axon re-enwrapment. In humans, regeneration is observed within the peripheral nervous system, while in the CNS injured axons exhibit limited ability to regenerate. This has also been described for the fruit fly Drosophila. Powerful genetic tools available in Drosophila have allowed the response to CNS insults to be probed and novel regulators with mammalian orthologs identified. The conservation of many regenerative pathways, despite considerable evolutionary separation, stresses that these signals are principal regulators and may serve as potential therapeutic targets. Here, we highlight the role of Drosophila CNS injury models in providing key insight into regenerative processes by exploring the underlying pathways that control glial and neuronal activation in response to insult, and their contribution to damage repair in the CNS.</jats:p

Frequency Vs. Length of Hot Spots Patrols: a Randomised Controlled Trial

RESEARCH QUESTION: Do shorter but more frequent patrol visits to the same crime hot spots reduce daily crime and anti-social behaviour (ASB) totals more effectively than less frequent but longer patrols, if the total time that police are present each day is held roughly constant? DATA: GPS measures from patrol officer body-worn radios tracked the time each officer spent within seven geo-fenced crime “hot spots” of 150 × 150 m, summing the number of both individual officer-minutes and patrol-minutes (with one or more officers present simultaneously) per day per hot spot, as well as number of visits and minutes per visit. Activity reports were used to detect the simultaneous presence of more than one officer, yielding the key independent variables of number and length of patrol visits in which one or more police officers were present. The dependent variable was total reports of crime and anti-social behaviour (ASB) identified within the hot spot boundaries each day of the experiment. METHOD: All seven hot spots of crime and ASB were randomly allocated each day to one of two patrol duration conditions for a period of 100 days (43 “short” visit days and 57 “long” visit days) between June and November 2015, with patrol time measures reported back to officers on the number and length of patrols conducted daily. The long visit model required three visits daily of 15 min duration each; the short visit model required nine visits daily of 5 min each. On all days, a target of 45 min of total patrol time was required. RESULTS: Actual patrol delivery measured by GPS and activity reports produced a mean of just over 24 patrol-minutes (of one or more officers present) on “long” days and just under 26 min on “short” days, so that dosage was approximately held constant to test the independent effect of more or fewer visits. The treatment as delivered on “long” days was a mean of 2.5 visits averaging 9.6 min each; on “short” days, the same officers delivered a mean of 5 visits averaging 5.2 min each. The less-frequent long visit model was more effective than the more-frequent short visit model, with mean counts of crime and ASB incidents 19.51% lower on long visit days =0.697 incidents per day compared to 0.561 incidents per day on short visit days (d = −0.175; p = 0.018). CONCLUSION: Controlling for the total patrol time spent at a hot spot each day, the difference between 2.5 longer visits and 5 shorter visits causes about 20% less crime when longer visits are delivered. These findings of the deterrent effect of increasing patrol visit length by 85% are consistent with Koper’s (1995) correlational observation that longer units of 10–15 min duration appeared optimal in creating a residual deterrent effect at a hot spot immediately after police leave the vicinity. Although this study cannot distinguish between crime reductions immediately after vs. long after police have left the scene, this is the first experiment to randomly assign a substantial difference (twice as many) in the number of visits daily to a hot spot, with almost twice as much time per visit when fewer visits are made. The use of random assignment of two different patrol models with the same total time in the same seven geographic units gives great confidence that using that time in fewer visits of longer duration causes less crime and anti-social behaviour than more visits of shorter duration

CERN@school: bringing CERN into the classroom

CERN@school brings technology from CERN into the classroom to aid with the teaching of particle physics. It also aims to inspire the next generation of physicists and engineers by giving participants the opportunity to be part of a national collaboration of students, teachers and academics, analysing data obtained from detectors based on the ground and in space to make new, curiosity-driven discoveries at school. CERN@school is based around the Timepix hybrid silicon pixel detector developed by the Medipix 2 Collaboration, which features a 300 μm thick silicon sensor bump-bonded to a Timepix readout ASIC. This defines a 256-by-256 grid of pixels with a pitch of 55 μm, the data from which can be used to visualise ionising radiation in a very accessible way. Broadly speaking, CERN@school consists of a web portal that allows access to data collected by the Langton Ultimate Cosmic ray Intensity Detector (LUCID) experiment in space and the student-operated Timepix detectors on the ground; a number of Timepix detector kits for ground-based experiments, to be made available to schools for both teaching and research purposes; and educational resources for teachers to use with LUCID data and detector kits in the classroom. By providing access to cutting-edge research equipment, raw data from ground and space-based experiments, CERN@school hopes to provide the foundation for a programme that meets the many of the aims and objectives of CERN and the project's supporting academic and industrial partners. The work presented here provides an update on the status of the programme as supported by the UK Science and Technology Facilities Council (STFC) and the Royal Commission for the Exhibition of 1851. This includes recent results from work with the GridPP Collaboration on using grid resources with schools to run GEANT4 simulations of CERN@school experiments

Life satisfaction and musculoskeletal complaints in a population seeking osteopathy care: consecutive sample of 611 patients.

BackgroundLife satisfaction is a component of the subjective well-being construct. Research consistently suggests that life satisfaction is associated with enhanced social benefits and improved health outcomes. However, its relationship to musculoskeletal health outcomes is underexplored. This study evaluates the life satisfaction of a patient population presenting with musculoskeletal complaints, and the relationship of life satisfaction with other health demographics and behaviours.MethodThe study used a consecutive sampling design. Patients attending the Victoria University Osteopathy Clinic (Melbourne, Australia) were invited to complete the PROMIS® General Life Satisfaction scale (GLSS) along with questions related to health demographics and behaviours.ResultsThe GLSS T-score was not significantly different for gender, being born outside of Australia, speaking English at home, or complaint chronicity.ConclusionsLife satisfaction did not appear to be related to a range of health and demographic variables in the current musculoskeletal pain cohort. The PROMIS® General Life Satisfaction scale could prove useful to explore the relationship between life satisfaction and treatment outcomes for musculoskeletal complaints

Scoping Potential Routes to UK Civil Unrest via the Food System: Results of a Structured Expert Elicitation

We report the results of a structured expert elicitation to identify the most likely types of potential food system disruption scenarios for the UK, focusing on routes to civil unrest. We take a backcasting approach by defining as an end-point a societal event in which 1 in 2000 people have been injured in the UK, which 40% of experts rated as “Possible (20–50%)”, “More likely than not (50–80%)” or “Very likely (>80%)” over the coming decade. Over a timeframe of 50 years, this increased to 80% of experts. The experts considered two food system scenarios and ranked their plausibility of contributing to the given societal scenario. For a timescale of 10 years, the majority identified a food distribution problem as the most likely. Over a timescale of 50 years, the experts were more evenly split between the two scenarios, but over half thought the most likely route to civil unrest would be a lack of total food in the UK. However, the experts stressed that the various causes of food system disruption are interconnected and can create cascading risks, highlighting the importance of a systems approach. We encourage food system stakeholders to use these results in their risk planning and recommend future work to support prevention, preparedness, response and recovery planning

Partitioning controls on Amazon forest photosynthesis between environmental and biotic factors at hourly to interannual timescales

Gross ecosystem productivity (GEP) in tropical forests varies both with the environment and with biotic changes in photosynthetic infrastructure, but our understanding of the relative effects of these factors across timescales is limited. Here, we used a statistical model to partition the variability of seven years of eddy covariance-derived GEP in a central Amazon evergreen forest into two main causes: variation in environmental drivers (solar radiation, diffuse light fraction, and vapor pressure deficit) that interact with model parameters that govern photosynthesis and biotic variation in canopy photosynthetic light-use efficiency associated with changes in the parameters themselves. Our fitted model was able to explain most of the variability in GEP at hourly (R2 = 0.77) to interannual (R2 = 0.80) timescales. At hourly timescales, we found that 75% of observed GEP variability could be attributed to environmental variability. When aggregating GEP to the longer timescales (daily, monthly, and yearly), however, environmental variation explained progressively less GEP variability: At monthly timescales, it explained only 3%, much less than biotic variation in canopy photosynthetic light-use efficiency, which accounted for 63%. These results challenge modeling approaches that assume GEP is primarily controlled by the environment at both short and long timescales. Our approach distinguishing biotic from environmental variability can help to resolve debates about environmental limitations to tropical forest photosynthesis. For example, we found that biotically regulated canopy photosynthetic light-use efficiency (associated with leaf phenology) increased with sunlight during dry seasons (consistent with light but not water limitation of canopy development) but that realized GEP was nonetheless lower relative to its potential efficiency during dry than wet seasons (consistent with water limitation of photosynthesis in given assemblages of leaves). This work highlights the importance of accounting for differential regulation of GEP at different timescales and of identifying the underlying feedbacks and adaptive mechanisms

The Microbiology of Permeable Pavements

SUMMARY Pervious pavement systems (meaning permeable pavements within this context and used interchangeably) are known to retain and degrade hydrocarbons within the structure of the pavement. The key to this decontamination has been shown to be the naturally occurring microbial communities living on the pavement building materials. Research by Formpave and Coventry University has shown that once oil is trapped on a suitable strongly oil-retaining geotextile membrane layer, the oil rapidly becomes a food source for the microbial communities. Oil is metabolised by aerobic bacteria and fungi that convert the oil into sugars such as glucose for growth and reproduction. Over time, a network of microbial growth spreads over the surface of Inbitex forming a biofilm, further improving the filtration and purification properties of the system. The presence of a large food source growing on the oil attracts larger predatory organisms such as protozoa and metazoa to the biofilm. These organisms play an important role in maintaining the free-draining characteristics of the geotextile and also the vigorous growth of the oil degrading organisms. An understanding of the processes underpinning the environmental benefits of permeable pavements is essential in order to optimise the operation of the system

Does Amazon forest leaf phenology mediate transpiration seasonality and hence, ecoclimate teleconnections?

Abstract OOS 11-5

The value of CCTV surveillance cameras as an investigative tool: an empirical analysis

There has been extensive research on the value of closed-circuit television (CCTV) for preventing crime, but little on its value as an investigative tool. This study sought to establish how often CCTV provides useful evidence and how this is affected by circumstances, analysing 251,195 crimes recorded by British Transport Police that occurred on the British railway network between 2011 and 2015. CCTV was available to investigators in 45% of cases and judged to be useful in 29% (65% of cases in which it was available). Useful CCTV was associated with significantly increased chances of crimes being solved for all crime types except drugs/weapons possession and fraud. Images were more likely to be available for more-serious crimes, and less likely to be available for cases occurring at unknown times or in certain types of locations. Although this research was limited to offences on railways, it appears that CCTV is a powerful investigative tool for many types of crime. The usefulness of CCTV is limited by several factors, most notably the number of public areas not covered. Several recommendations for increasing the usefulness of CCTV are discussed