Development and flight test of a helicopter, X-band, portable precision landing system concept

A beacon landing system (BLS) is being developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. The system is based on state-of-of-the-art X-band radar technology and digital processing techniques. The bLS airborne hardware consists of an X-band receiver and a small micropreocessor, installed in conjunction wht the aircraft instrument landing system (ILS) receiver. The microprocessor analyzes the X-band, BLS pulses and outputs ILS-compatible localizer and glide slope signals. Range information is obtained using an on-board weather/mapping radar in conjunction with the BLS. The ground station is an inexpensive, portable unit; it weighs less than 70 lb and can be quickly deployed at a landing site. Results from the flight-test program show that the BLS has a significant potential for providing rotorcaraft with low-cost, precision instrument approach capability in remote areas

Development and flight test of a helicopter compact, portable, precision landing system concept

An airborne, radar-based, precision approach concept is being developed and flight tested as a part of NASA's Rotorcraft All-Weather Operations Research Program. A transponder-based beacon landing system (BLS) applying state-of-the-art X-band radar technology and digital processing techniques, was built and is being flight tested to demonstrate the concept feasibility. The BLS airborne hardware consists of an add-on microprocessor, installed in conjunction with the aircraft weather/mapping radar, which analyzes the radar beacon receiver returns and determines range, localizer deviation, and glide-slope deviation. The ground station is an inexpensive, portable unit which can be quickly deployed at a landing site. Results from the flight test program show that the BLS concept has a significant potential for providing rotorcraft with low-cost, precision instrument approach capability in remote areas

Atomic-scale compensation phenomena at polar interfaces

The interfacial screening charge that arises to compensate electric fields of dielectric or ferroelectric thin films is now recognized as the most important factor in determining the capacitance or polarization of ultrathin ferroelectrics. Here we investigate using aberration-corrected electron microscopy and density functional theory how interfaces cope with the need to terminate ferroelectric polarization. In one case, we show evidence for ionic screening, which has been predicted by theory but never observed. For a ferroelectric film on an insulating substrate, we found that compensation can be mediated by interfacial charge generated, for example, by oxygen vacancies.Comment: 3 figure

Do actions occur inside the body?

The paper offers a critical examination of Jennifer Hornsby's view that actions are internal to the body. It focuses on three of Hornsby's central claims: (P) many actions are bodily movements (in a special sense of the word “movement”) (Q) all actions are tryings; and (R) all actions occur inside the body. It is argued, contra Hornsby, that we may accept (P) and (Q) without accepting also the implausible (R). Two arguments are first offered in favour of the thesis (Contrary-R): that no actions occur inside the body. Three of Hornsby's arguments in favour of R are then examined. It is argued that we need to make a distinction between the causes and the causings of bodily movements (in the ordinary sense of the word “movement”) and that actions ought to be identified with the latter rather than the former. This distinction is then used to show how Hornsby's arguments for (R) may be resisted

Intense CIII] 1907,1909 emission from a strong Lyman continuum emitting galaxy

We have obtained the first complete ultraviolet (UV) spectrum of a strong Lyman continuum(LyC) emitter at low redshift -- the compact, low-metallicity, star-forming galaxy J1154+2443 -- with a Lyman continuum escape fraction of 46% discovered recently. The Space Telescope Imaging Spectrograph spectrum shows strong Lya and CIII] 1909 emission, as well as OIII] 1666. Our observations show that strong LyC emitters can have UV emission lines with a high equivalent width (e.g. EW(CIII])$=11.7 \pm 2.9 \AA$ rest-frame), although their equivalent widths should be reduced due to the loss of ionizing photons. The intrinsic ionizing photon production efficiency of J1154+2443 is high, $\log(\xi_{\rm ion}^0)=25.56$ erg$^{-1}$ Hz, comparable to that of other recently discovered $z \sim 0.3-0.4$ LyC emitters. Combining our measurements and earlier determinations from the literature, we find a trend of increasing $\xi_{\rm ion}^0$ with increasing CIII] 1909 equivalent width, which can be understood by a combination of decreasing stellar population age and metallicity. Simple ionization and density-bounded photoionization models can explain the main observational features including the UV spectrum of J1154+2443.Comment: 5 pages, 4 figures. Accepted for publication in A&A Letter

Health-related quality of life before and after management in adults referred to otolaryngology: rospective national study

Objective: An assessment of the effect of otolaryngological management on the health-related quality of life of patients. Design: Application of the Health Utilities Index mark 3 (HUI-3) before and after treatment; application of the Glasgow Benefit Inventory (GBI) after treatment. Setting: Six otolaryngological departments around Scotland. Participants: A 9005 adult patients referred to outpatient clinics. Main outcome measures: Complete HUI-3 data was collected from 4422 patients; complete GBI data from 4235; complete HUI-3 and GBI data from 3884. Results: The overall change in health related quality of life from before to after management was just +0.02. In the majority of subgroups of data (classified by type of management) there was essentially no change in HUI-3 score. The major exceptions were those patients provided with a hearing aid (mean change 0.08) and those whose problem was managed surgically (mean change 0.04). The mean GBI score was 5.3 which is low. Those managed surgically reported a higher GBI score of 13.0. Conclusion: We found that patients treated surgically or given a hearing aid reported a significant improvement in their health related quality of life after treatment in otolaryngology departments. In general, patients treated in other ways reported no significant improvement. We argue that future research should look carefully at patient groups where there is unexpectedly little benefit from current treatment methods and consider more effective methods of management

Tracking the evolution of cancer cell populations through the mathematical lens of phenotype-structured equations

Background: A thorough understanding of the ecological and evolutionary mechanisms that drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer research community. In this respect, mathematical modelling can complement experimental cancer research by offering alternative means of understanding the results of in vitro and in vivo experiments, and by allowing for a quick and easy exploration of a variety of biological scenarios through in silico studies. Results: To elucidate the roles of phenotypic plasticity and selection pressures in tumour relapse, we present here a phenotype-structured model of evolutionary dynamics in a cancer cell population which is exposed to the action of a cytotoxic drug. The analytical tractability of our model allows us to investigate how the phenotype distribution, the level of phenotypic heterogeneity, and the size of the cell population are shaped by the strength of natural selection, the rate of random epimutations, the intensity of the competition for limited resources between cells, and the drug dose in use. Conclusions: Our analytical results clarify the conditions for the successful adaptation of cancer cells faced with environmental changes. Furthermore, the results of our analyses demonstrate that the same cell population exposed to different concentrations of the same cytotoxic drug can take different evolutionary trajectories, which culminate in the selection of phenotypic variants characterised by different levels of drug tolerance. This suggests that the response of cancer cells to cytotoxic agents is more complex than a simple binary outcome, i.e., extinction of sensitive cells and selection of highly resistant cells. Also, our mathematical results formalise the idea that the use of cytotoxic agents at high doses can act as a double-edged sword by promoting the outgrowth of drug resistant cellular clones. Overall, our theoretical work offers a formal basis for the development of anti-cancer therapeutic protocols that go beyond the 'maximum-tolerated-dose paradigm', as they may be more effective than traditional protocols at keeping the size of cancer cell populations under control while avoiding the expansion of drug tolerant clones. Reviewers: This article was reviewed by Angela Pisco, Sébastien Benzekry and Heiko Enderling

Effects of an advection term in nonlocal lotka-volterra equations

Nonlocal Lotka-Volterra equations have the property that solutions concentrate as Dirac masses in the limit of small diffusion. In this paper, we show how the presence of an advection term changes the location of the concentration points in the limit of small diffusion and slow drift. The mathematical interest lies in the formalism of constrained Hamilton-Jacobi equations. Our motivations come from previous models of evolutionary dynamics in phenotype-structured populations [R.H. Chisholm, T. Lorenzi, A. Lorz, et al., Cancer Res., 75, 930-939, 2015], where the diffusion operator models the effects of heritable variations in gene expression, while the advection term models the effect of stress-induced adaptation

Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation

Background Drug-induced drug resistance in cancer has been attributed to diverse biological mechanisms at the individual cell or cell population scale, relying on stochastically or epigenetically varying expression of phenotypes at the single cell level, and on the adaptability of tumours at the cell population level. Scope of review We focus on intra-tumour heterogeneity, namely between-cell variability within cancer cell populations, to account for drug resistance. To shed light on such heterogeneity, we review evolutionary mechanisms that encompass the great evolution that has designed multicellular organisms, as well as smaller windows of evolution on the time scale of human disease. We also present mathematical models used to predict drug resistance in cancer and optimal control methods that can circumvent it in combined therapeutic strategies. Major conclusions Plasticity in cancer cells, i.e., partial reversal to a stem-like status in individual cells and resulting adaptability of cancer cell populations, may be viewed as backward evolution making cancer cell populations resistant to drug insult. This reversible plasticity is captured by mathematical models that incorporate between-cell heterogeneity through continuous phenotypic variables. Such models have the benefit of being compatible with optimal control methods for the design of optimised therapeutic protocols involving combinations of cytotoxic and cytostatic treatments with epigenetic drugs and immunotherapies. General significance Gathering knowledge from cancer and evolutionary biology with physiologically based mathematical models of cell population dynamics should provide oncologists with a rationale to design optimised therapeutic strategies to circumvent drug resistance, that still remains a major pitfall of cancer therapeutics. This article is part of a Special Issue entitled “System Genetics” Guest Editor: Dr. Yudong Cai and Dr. Tao Huang

Do galaxies that leak ionizing photons have extreme outflows?

To reionize the early universe, high-energy photons must escape the galaxies that produce them. It has been suggested that stellar feedback drives galactic outflows out of star-forming regions, creating low density channels through which ionizing photons escape into the inter-galactic medium. We compare the galactic outflow properties of confirmed Lyman continuum (LyC) leaking galaxies to a control sample of nearby star-forming galaxies to explore whether the outflows from leakers are extreme as compared to the control sample. We use data from the Cosmic Origins Spectrograph on the Hubble Space Telescope to measure the equivalent widths and velocities of Si II and Si III absorption lines, tracing neutral and ionized galactic outflows. We find that the Si II and Si III equivalent widths of the LyC leakers reside on the low-end of the trend established by the control sample. The leakers' velocities are not statistically different than the control sample, but their absorption line profiles have a different asymmetry: their central velocities are closer to their maximum velocities. The outflow kinematics and equivalent widths are consistent with the scaling relations between outflow properties and host galaxy properties -- most notably metallicity -- defined by the control sample. Additionally, we use the Ly\alpha\ profiles to show that the Si II equivalent width scales with the Ly\alpha\ peak velocity separation. We determine that the low equivalent widths of the leakers are likely driven by low metallicities and low H I column densities, consistent with a density-bounded ionization region, although we cannot rule out significant variations in covering fraction. While we do not find that the LyC leakers have extreme outflow velocities, the low maximum-to-central velocity ratios demonstrate the importance of the acceleration and density profiles for LyC and Ly\alpha\ escape. [abridged]Comment: 17 pages, 8 Figures. Accepted for publication in Astronomy & Astrophysic