Evaluation of Two Estrus Synchronization Protocols in Dairy Cattle at North Shoa Zone Ethiopia

This study was initiated to change the hesitation of the farmer on the effectiveness of estrus synchronization under their (Ethiopian small holder) livestock management system using two synchronization protocols. Non-pregnant animals with normal reproductive tract and that fulfilled the preconditions for estrus synchronization were considered for treatment & assigned into two synchronization protocols (single PGF2α injection; and double PGF2α injection). Among 94 (27 heifer and 67 cows) synchronized cows using one and two injections of PGF2α protocols 26 heifers and 63 cows (89/94.7%) were exhibited estrus by visual observation and rectal palpation the remaining 5 (5.3%) did not illustrate heat. The overall pregnancy was 59.6 % with overall birth 94.3 %. High pregnancy was obtained in the double injection of PGF2α treatment group (63.1 %) than animals treated with one shot protocol 55.8 % there were statistically significant difference between treatments (p<0.05). Higher pregnancy was obtained from cross breed animals than local breeds. More over most of the animals come to estrus greater than 96 hrs. There was also significant difference between technicians on detecting the CL and conception. The estrus response, conception rate, pregnancy rate and calving rate was higher in both protocols so producers or farmers can use either the two protocols to achieve remarkable result but tight follow-ups and more resources are need to be exploited at farmer level

Reimagining invasions; the social and cultural impacts of Prosopis on pastoralists in Southern Afar

Abstract Whilst the environmental impacts of biological invasions are clearly conceptualised and there is growing evidence on the economic benefits and costs, the social and cultural dimensions remain poorly understood. This paper presents the perceptions of pastoralist communities in southern Afar, Ethiopian lowlands, on one invasive species, Prosopis juliflora. The socio-cultural impacts are assessed, and the manner in which they interact with other drivers of vulnerability, including political marginalisation, sedentarisation and conflict, is explored. The research studied 10 communities and undertook semi-structured interviews and focus group discussions with pastoralists and agro-pastoralists. These results were supported by interviews with community leaders and key informants. The benefits and costs were analysed using the asset-based framework of the Sustainable Livelihoods Framework and the subject-focused approach of Wellbeing in Development. The results demonstrate that the costs of invasive species are felt across all of the livelihood capital bases (financial, natural, physical, human and social) highlighted within the framework and that the impacts cross multiple assets, such as reducing access through blocking roads. The concept of Wellbeing in Development provides a lens to examine neglected impacts, like conflict, community standing, political marginalisation and cultural impoverishment, and a freedom of definition and vocabulary to allow the participants to define their own epistemologies. The research highlights that impacts spread across assets, transcend objective and subjective classification, but also that impacts interact with other drivers of vulnerability. Pastoralists report deepened and broadened conflict, complicated relationships with the state and increased sedentarisation within invaded areas. The paper demonstrates that biological invasions have complex social and cultural implications beyond the environmental and economic costs which are commonly presented. Through synthesising methodologies and tools which capture local knowledge and perceptions, these implications and relationships are conceptualised

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. Findings Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer. Interpretation As the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed. Funding Bill & Melinda Gates Foundation

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Metasomatized lithospheric mantle beneath Turkana depression in southern Ethiopia (the East Africa Rift): Geochemical and Sr-Nd-Pb isotopic characteristics

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The UM-CIRHT Framework for Integrating Comprehensive Contraception and Abortion Care Competencies into Health Professions Education

The underpinning of the framework developed by the Center for International Reproductive Health Training at the University of Michigan (UM-CIRHT) is the integration of competency-based training in contraception and CAC within curricula for medical, midwifery, and nursing students and Obstetrics and Gynecology (Ob-Gyn) residents. By exposing trainees to all competencies early on, students are expected to develop the requisite skills and values to provide comprehensive RH services after graduation, ultimately improving access and reducing morbidity and mortality from unintended pregnancy and unsafe abortion. To achieve this, UM-CIRHT partners with academic institutions to support curricular enhancement and ensure competency-based learning and assists in its implementation through various faculty development efforts and infrastructure enhancements, including simulation lab setup or augmentation.The goal of this framework document is to describe the approach UM-CIRHT uses to execute its core programmatic and operational strategies for interested countries and/or institutions that aspire to enhance preservice training in family planning and comprehensive abortion care in their particular settings.https://deepblue.lib.umich.edu/bitstream/2027.42/148155/1/um-cirht-framework-for-integrating-comprehensive.pdf-1Description of um-cirht-framework-for-integrating-comprehensive.pdf : Framework (PDF

Evaluation and comparison of post-vaccination adverse effects among Janssen and Oxford-AstraZeneca vaccinated adult individuals in Debre Tabor Town: A cross- sectional survey in Northwest Ethiopia

COVID 19 vaccination has recently been launched globally to halt the pandemic. But COVID 19 vaccines have some adverse effects that raise concerns in the global community. This study aimed to evaluate and compare the adverse effects of Janssen and Oxford-AstraZeneca vaccinated adults. A community-based cross-sectional study was conducted from March 15 to 30, 2022 among 421 (211 Janssen and 210 Astra Zeneca vaccinated) adults recruited by a convenience sampling technique in Debre Tabor Town, Northwest Ethiopia. Data were collected via face-to-face interviews and by reviewing the immunization card. Chi-square test, independent t-test, and Mann-Whitney test were used to compare the adverse symptoms and related parameters between the two vaccines. A linear regression model was also used to identify predictors of the number of post-vaccination symptoms. The majority (75.8%) of participants reported at least one side effect after vaccination. Adverse symptoms had a significantly greater occurrence (p < .05) among recipients of the AstraZeneca vaccine (84.8%) than receivers of the Janssen vaccine (66.8%). The main adverse symptoms were injection site pain, fever, fatigue, arthralgia, and myalgia in both vaccines. Significant variations (p < .05) between the receipts of the two vaccines were shown in injection site pain, fever, and arthralgia. The total number of symptoms was significantly higher (p < .05) in participants with female sex, younger age, BMI <25 kg/m2, no prior COVID 19, and those who had received AstraZeneca vaccine. Thus, the authors advise that they should receive vaccines with no hesitation, while continuous tracking of vaccine safety is kept in place