Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia

The study aims to evaluate the correlation of testicular sperm extraction (TESE) and histopathology with various features of non-obstructive azoospermia (NOA) cases who consulted to our university-based infertility clinic, and the probability of prompting couples about TESE success and to investigate the cost reduction chance through cost-beneficial aspects

Magnetic resonance imaging and morphometric histologic analysis of prostate tissue composition in predicting the clinical outcome of terazosin therapy in benign prostatic hyperplasia

Purpose: To determine whether magnetic resonance imaging (MRI) or quantitative color-imaged morphometric analysis (MA) of the prostate gland are related to the clinical response to terazosin. Methods: Thirty-six male patients with symptomatic benign prostatic hyperplasia (BPH) with a serum prostate-specific antigen level of 4-10 ng/mL underwent MRI with body coil, transrectal prostate ultrasonography and biopsy prior to terazosin therapy. For MRI-determined stromal and non-stromal BPH, the ratio of the signal intensity of the inner gland to the obturator internus muscle was evaluated. Histologic sections were stained with hematoxylin and eosin. The MA of the specimens was performed by Samba 2000. Results of the two techniques were interpreted according to the terazosin therapy results. Results: The mean stromal percentage was 60.5 ± 18.0%. No statistically significant relationship was found between the clinical outcome of terazosin and the MRI findings. The MA results showed a significant relationship between the percentage of stroma and the percent change of the peak urinary flow rate, but not with the percent change of the international prostate symptom score after terazosin therapy (P < 0.05). Conclusion: Magnetic resonance imaging alone is not sufficient in predicting the response to terazosin therapy. Morphometric analysis of BPH tissue composition can be used in predicting the clinical outcome of terazosin therapy but it is suitable only in patients for whom prostatic biopsy is necessary in order to rule out prostate cancer

The relationship between microscopic hematuria and bladder cancer: Are currently available diagnostic methods reliable? [Mikroskopik hematüri ile mesane kanserinin ilişkisi: Bugün için kullanilan tani yöntemleri güvenilir mi?]

Objective: This study aimed to evaluate the sensitivity and specificity of radiological diagnostic methods, urinary biomarkers and urine cytology for patients with microscopic hematuria in the diagnosis of bladder cancer. Materials and methods: A total of 150 patients with the initial diagnosis of microscopic hematuria were included in the study. Patients were prospectively evaluated in terms of urinary symptomatology, physical examination, smoking habits, intravenous pyelography (IVP), abdominal ultrasonography (USG), Nuclear Matrix Protein 22 (NMP22), urine cytology and NMP22 BladderChek® test. The cut-off point for NMP22 test was accepted as 10 U/mL. Results: Mean age of the study population was 49.8±10.79 years with a male to female ratio of 1.08 (78/72). Overall, 10.7% (n=16) of patients had pathological diagnosis of bladder cancer, whereas 89.5% of the study population had no etiology for microhematuria. IVP was considered as the most sensitive and specific test in the diagnosis of bladder cancer. However, voided urine cytology was the least sensitive test, although it has the same specificity with IVP. The best sensitivity and specificity values were demonstrated when NMP22 and abdominal USG were used in double-test combinations. Conclusion: In microscopic hematuria, the combination of radiological methods with tumor markers such as NMP22 BladderChek® test, provides 100% sensitivity, and protects nearly half of cases from unnecessary cystoscopies

Lokalize prostat kanserinde uygulanan küratif tedaviler ile İlgili hasta alg i̇laması ve tedavi memnuniyeti

Objective: To assess and compare the treatment perception and satisfaction of the patients who underwent radical retropubic prostatectomy (RRP) and external beam radiotherapy (RT) for localized prostate cancer. Material and Methods: The treatment decision, satisfaction and post-treatment parameters of 45 (53.5%) and 39 (46.5%) patients who underwent RRP and RT, respectively for localized prostate cancer between 2003 and 2008 were evaluated with a form consisting of 17 questions. The data obtained from these two groups were compared with each other. Results: The mean age of the patients who underwent RT and RRP were 72.12 ±5.41 and 62.63 ±8.46 years, respectively (p<0.001). Of patients, 68 (81%) declared that they were mostly satisfied with their treatment modalities. Fourteen (31.1%) cases in RRP and 17 (43.6%) cases in RT group thought that their cancer was not completely treated (p=0.200). When impotence, incontinence and bowel problems following both treatment modalities were considered, only bowel problems were detected more frequently in RT group group compared to RRP group (p=0.036). Fourteen (35.9%) patients in RT group and 21 (46.7%) patients in RRP group declared their overall health status as very good or perfect after the treatment (p=0.811). Conclusion: The vast majority of the patients who were treated with either RT or RRP for localized prostate cancer are satisfied with these treatments. © 2012 by Türkiye Klinikleri