2,109 research outputs found

    On the mistake in the implementation of the minimal model of the dual parameterization and resulting inability to describe the high-energy DVCS data

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    We correct the mistaken claim made in \cite{Guzey:2005ec,Guzey:2006xi} that the minimal model of the dual parameterization of nucleon generalized parton distributions (GPDs) gives a good, essentially model-independent description of high-energy data on deeply virtual Compton scattering (DVCS). In the implementation of the dual parameterization in \cite{Guzey:2005ec,Guzey:2006xi}, the numerical prefactor of two in front of the DVCS amplitude was missing. We show that the corrected minimal model of the dual parameterization significantly overestimates the HERA data (H1 and ZEUS) on the DVCS cross section.Comment: 8 pages, 1 figur

    Modeling toothpaste brand choice: An empirical comparison of artificial neural networks and multinomial probit model

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    Copyright @ 2010 Atlantis PressThe purpose of this study is to compare the performances of Artificial Neural Networks (ANN) and Multinomial Probit (MNP) approaches in modeling the choice decision within fast moving consumer goods sector. To do this, based on 2597 toothpaste purchases of a panel sample of 404 households, choice models are built and their performances are compared on the 861 purchases of a test sample of 135 households. Results show that ANN's predictions are better while MNP is useful in providing marketing insight

    Transposons: catch them if you can

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    Transposons and their host genomes are entangled in an evolutionary arms race, recounts Tuğçe Aktaş

    FLASH: ultra-fast protocol to identify RNA-protein interactions in cells

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    Determination of the in vivo binding sites of RNA-binding proteins (RBPs) is paramount to understanding their function and how they affect different aspects of gene regulation. With hundreds of RNA-binding proteins identified in human cells, a flexible, high-resolution, high-throughput, highly multiplexible and radioactivity-free method to determine their binding sites has not been described to date. Here we report FLASH (Fast Ligation of RNA after some sort of Affinity Purification for High-throughput Sequencing), which uses a special adapter design and an optimized protocol to determine protein-RNA interactions in living cells. The entire FLASH protocol, starting from cells on plates to a sequencing library, takes 1.5 days. We demonstrate the flexibility, speed and versatility of FLASH by using it to determine RNA targets of both tagged and endogenously expressed proteins under diverse conditions in vivo

    Nuclear speckles: dynamic hubs of gene expression regulation

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    Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity. Eukaryotic cells solve these problems by restricting such reactions into diffusion-restricted compartments within the cell called organelles that can be separated from their environment by a lipid membrane, or into membrane-less compartments that form through liquid–liquid phase separation (LLPS). One of the most easily noticeable and the earliest discovered organelle is the nucleus, which harbors the genetic material in cells where transcription by RNA polymerases produces most of the messenger RNAs and a plethora of noncoding RNAs, which in turn are required for translation of mRNAs in the cytoplasm. The interior of the nucleus is not a uniform soup of biomolecules and rather consists of a variety of membrane-less bodies, such as the nucleolus, nuclear speckles (NS), paraspeckles, Cajal bodies, histone locus bodies, and more. In this review, we will focus on NS with an emphasis on recent developments including our own findings about the formation of NS by two large IDR-rich proteins SON and SRRM2

    The effect of sample properties on the electron velocity in quantum Hall bars

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    We report on our theoretical investigation of the effects of the confining potential profile and sample size on the electron velocity distribution in (narrow) quantum-Hall systems. The electrostatic properties of the electron system are obtained by the Thomas-Fermi-Poisson nonlinear screening theory. The electron velocity distribution as a function of the lateral coordinate is obtained from the slope of the screened potential at the Fermi level and within the incompressible strips (ISs). We compare our findings with the recent experiments.Comment: 8 pages, 6 figure

    Capacity Bounds and Concatenated Codes Over Segmented Deletion Channels

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    Cataloged from PDF version of article.We develop an information theoretic characterization and a practical coding approach for segmented deletion channels. Compared to channels with independent and identically distributed (i.i.d.) deletions, where each bit is independently deleted with an equal probability, the segmentation assumption imposes certain constraints, i.e., in a block of bits of a certain length, only a limited number of deletions are allowed to occur. This channel model has recently been proposed and motivated by the fact that for practical systems, when a deletion error occurs, it is more likely that the next one will not appear very soon. We first argue that such channels are information stable, hence their channel capacity exists. Then, we introduce several upper and lower bounds with two different methods in an attempt to understand the channel capacity behavior. The first scheme utilizes certain information provided to the transmitter and/or receiver while the second one explores the asymptotic behavior of the bounds when the average bit deletion rate is small. In the second part of the paper, we consider a practical channel coding approach over a segmented deletion channel. Specifically, we utilize outer LDPC codes concatenated with inner marker codes, and develop suitable channel detection algorithms for this scenario. Different maximum-a-posteriori (MAP) based channel synchronization algorithms operating at the bit and symbol levels are introduced, and specific LDPC code designs are explored. Simulation results clearly indicate the advantages of the proposed approach. In particular, for the entire range of deletion probabilities less than unity, our scheme offers a significantly larger transmission rate compared to the other existing solutions in the literature
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