1,311 research outputs found
XO-5b: A Transiting Jupiter-sized Planet With A Four Day Period
The star XO-5 (GSC 02959-00729, V=12.1, G8V) hosts a Jupiter-sized,
Rp=1.15+/-0.12 Rjup, transiting extrasolar planet, XO-5b, with an orbital
period of P=4.187732+/-0.00002 days. The planet mass (Mp=1.15+/-0.08 Mjup) and
surface gravity (gp=22+/-5 m/s^2) are significantly larger than expected by
empirical Mp-P and Mp-P-[Fe/H] relationships. However, the deviation from the
Mp-P relationship for XO-5b is not large enough to suggest a distinct type of
planet as is suggested for GJ 436b, HAT-P-2b, and XO-3b. By coincidence XO-5
overlies the extreme H I plume that emanates from the interacting galaxy pair
NGC 2444/NGC 2445 (Arp 143).Comment: 10 pages, 9 Figures, Submitted to Ap
A Transiting Planet of a Sun-like Star
A planet transits an 11th magnitude, G1V star in the constellation Corona
Borealis. We designate the planet XO-1b, and the star, XO-1, also known as GSC
02041-01657. XO-1 lacks a trigonometric distance; we estimate it to be 200+-20
pc. Of the ten stars currently known to host extrasolar transiting planets, the
star XO-1 is the most similar to the Sun in its physical characteristics: its
radius is 1.0+-0.08 R_Sun, its mass is 1.0+-0.03 M_Sun, V sini < 3 km/s, and
its metallicity [Fe/H] is 0.015+-0.04. The orbital period of the planet XO-1b
is 3.941534+-0.000027 days, one of the longer ones known. The planetary mass is
0.90+-0.07 M_Jupiter, which is marginally larger than that of other transiting
planets with periods between 3 and 4 days. Both the planetary radius and the
inclination are functions of the spectroscopically determined stellar radius.
If the stellar radius is 1.0+-0.08 R_Sun, then the planetary radius is
1.30+-0.11 R_Jupiter and the inclination of the orbit is 87.7+-1.2 degrees. We
have demonstrated a productive international collaboration between professional
and amateur astronomers that was important to distinguishing this planet from
many other similar candidates.Comment: 31 pages, 9 figures, accepted for part 1 of Ap
TRAIL Coated Genetically Engineered Immunotherapeutic Nano-Ghosts Vesicles Target Human Melanoma-Avoiding the Need for High Effective Therapeutic Concentration of TRAIL
Cancer cell therapy using cytotoxic T lymphocytes (CTL) or mesenchymal stem cells (MSC) possesses hurdles due to the cells, susceptibility to host induced changes. Here, versatile inanimate broadly applicable nanovesicles, termed immunotherapeutic-nano-ghosts (iNGs), are armed with inherent surface-associated targeting and therapeutic capabilities in which the promise and benefits of MSC therapy and T cell immunotherapy are combined into one powerful off-the-shelf approach for treating malignant diseases. To mimic the cytotoxic or immunosuppressive functions of T cells, iNG are produced from MSC that were genetically engineered (GE) or metabolically manipulated to express additional membrane-bound proteins, endowing the NGs derived therefrom with additional surface-associated functions such as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). iNGs from GE-MSCs (GE-iNGs) show superior TRAIL retention and induce apoptosis in different cancer cell lines in vitro. In vivo studies on a human melanoma model demonstrate that a systemic, three-day frequency, administration of GE-iNGs result in tumor inhibition comparable to a six orders of magnitude higher concentration of soluble TRAIL. The iNGs are therefore a promising nanovesicle platform that can affect tumors in a non-immunogenic manner while avoiding the need for a highly effective therapeutic concentration
XO-2b: Transiting Hot Jupiter in a Metal-rich Common Proper Motion Binary
We report on a V=11.2 early K dwarf, XO-2 (GSC 03413-00005), that hosts a
Rp=0.98+0.03/-0.01 Rjup, Mp=0.57+/-0.06 Mjup transiting extrasolar planet,
XO-2b, with an orbital period of 2.615857+/-0.000005 days. XO-2 has high
metallicity, [Fe/H]=0.45+/-0.02, high proper motion, mu_tot=157 mas/yr, and has
a common proper motion stellar companion with 31" separation. The two stars are
nearly identical twins, with very similar spectra and apparent magnitudes. Due
to the high metallicity, these early K dwarf stars have a mass and radius close
to solar, Ms=0.98+/-0.02 Msolar and Rs=0.97+0.02/-0.01 Rsolar. The high proper
motion of XO-2 results from an eccentric orbit (Galactic pericenter, Rper<4
kpc) well confined to the Galactic disk (Zmax~100 pc). In addition, the phase
space position of XO-2 is near the Hercules dynamical stream, which points to
an origin of XO-2 in the metal-rich, inner Thin Disk and subsequent dynamical
scattering into the solar neighborhood. We describe an efficient Markov Chain
Monte Carlo algorithm for calculating the Bayesian posterior probability of the
system parameters from a transit light curve.Comment: 14 pages, 10 Figures, Accepted in ApJ. Negligible changes to XO-2
system properties. Removed Chi^2 light curve analysis section, and simplified
MCMC light curve analysis discussio
Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats
Bromochloromethane (BCM) is a volatile compound and a by-product of disinfection of water by chlorination. Physiologically based pharmacokinetic (PBPK) models are used in risk assessment applications. An updated PBPK model for BCM is generated and applied to hypotheses testing calibrated using vapor uptake data. The two different metabolic hypotheses examined are (1) a two-pathway model using both CYP2E1 and glutathione transferase enzymes and (2) a two-binding site model where metabolism can occur on one enzyme, CYP2E1. Our computer simulations show that both hypotheses describe the experimental data in a similar manner. The two pathway results were comparable to previously reported values (Vmax⥠= 3.8âmg/hour, Km = 0.35âmg/liter, and kGST = 4.7â/hour). The two binding site results were VmaxâĄ1 = 3.7âmg/hour, KmâĄ1 = 0.3âmg/hour, CL2 = 0.047âliter/hour. In addition, we explore the sensitivity of different parameters for each model using our obtained optimized values
Noncanonical quantum optics
Modification of the right-hand-side of canonical commutation relations (CCR)
naturally occurs if one considers a harmonic oscillator with indefinite
frequency. Quantization of electromagnetic field by means of such a non-CCR
algebra naturally removes the infinite energy of vacuum but still results in a
theory which is very similar to quantum electrodynamics. An analysis of
perturbation theory shows that the non-canonical theory has an automatically
built-in cut-off but requires charge/mass renormalization already at the
nonrelativistic level. A simple rule allowing to compare perturbative
predictions of canonical and non-canonical theories is given. The notion of a
unique vacuum state is replaced by a set of different vacua. Multi-photon
states are defined in the standard way but depend on the choice of vacuum.
Making a simplified choice of the vacuum state we estimate corrections to
atomic lifetimes, probabilities of multiphoton spontaneous and stimulated
emission, and the Planck law. The results are practically identical to the
standard ones. Two different candidates for a free-field Hamiltonian are
compared.Comment: Completely rewritten version of quant-ph/0002003v2. There are
overlaps between the papers, but sections on perturbative calculations show
the same problem from different sides, therefore quant-ph/0002003v2 is not
replace
Analysis of fundamental physical factors influencing channel bank erosion:results for contrasting catchments in England and Wales
Channel bank erosion processes are controlled by numerous factors and as such are both temporally and spatially variable. The significance of channel bank erosion to the sediment budget is difficult to quantify without extensive fieldwork/data analysis. In this study, the importance of key physical factors controlling channel bank erosion, including channel slope, upstream catchment area, channel confinement, and sinuosity were explored using regression analysis. The resulting analysis can be used in practical studies to provide a first approximation of bank erosion rates (in catchments similar to those investigated). A dataset of channel bank erosion rates covering eight contrasting river catchments across England and Wales, over a time period of up to 150 years was created using a modified GIS methodology. The best predictors were found to upstream area, channel confinement and sinuosity with respect to dimensionless width averaged retreat rates (m m-1yr-1). Notwithstanding these relationships, the results highlight the variability of the magnitude of sediment production by channel bank erosion both within and between catchments
XO-3b: A Massive Planet in an Eccentric Orbit Transiting an F5V Star
We report the discovery of a massive (Mpsini = 13.02 +/- 0.64 Mjup; total
mass 13.25 +/- 0.64 Mjup), large (1.95 +/- 0.16 Rjup) planet in a transiting,
eccentric orbit (e = 0.260 +/- 0.017) around a 10th magnitude F5V star in the
constellation Camelopardalis. We designate the planet XO-3b, and the star XO-3,
also known as GSC 03727-01064. The orbital period of XO-3b is 3.1915426 +/-
0.00014 days. XO-3 lacks a trigonometric distance; we estimate its distance to
be 260 +/- 23 pc. The radius of XO-3 is 2.13 +/- 0.21 Rsun, its mass is 1.41
+/- 0.08 Msun, its vsini = 18.54 +/- 0.17 km/s, and its metallicity is [Fe/H] =
-0.177 +/- 0.027. This system is unusual for a number of reasons. XO-3b is one
of the most massive planets discovered around any star for which the orbital
period is less than 10 days. The mass is near the deuterium burning limit of 13
Mjup, which is a proposed boundary between planets and brown dwarfs. Although
Burrows et al. (2001) propose that formation in a disk or formation in the
interstellar medium in a manner similar to stars is a more logical way to
differentiate planets and brown dwarfs, our current observations are not
adequate to address this distinction. XO-3b is also unusual in that its
eccentricity is large given its relatively short orbital period. Both the
planetary radius and the inclination are functions of the spectroscopically
determined stellar radius. Analysis of the transit light curve of XO-3b
suggests that the spectroscopically derived parameters may be over estimated.
Though relatively noisy, the light curves favor a smaller radius in order to
better match the steepness of the ingress and egress. The light curve fits
imply a planetary radius of 1.25 +/- 0.15 Rjup, which would correspond to a
mass of 12.03 +/- 0.46 Mjup.Comment: 26 pages, 10 figures. Accepted by ApJ. Current version has several
small corrections as a result of a bug in the fitting softwar
Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade
Cancers are a heterogeneous mix of cells, some of which exhibit cancer stem cell-like characteristics including ATP-dependent drug efflux and elevated tumorigenic potential. To determine whether aerodigestive squamous cell carcinomas (SCCs) contain a subpopulation of cancer stem cell-like cells, we performed Hoechst dye efflux assays using four independent cell lines. Results revealed the presence of a rare, drug effluxing stem cell-like side population (SP) of cells within all cell lines tested (SCC-SP cells). These cells resembled previously characterised epithelial stem cells, and SCC-SP cell abundance was positively correlated with overall cellular density and individual cell quiescence. Serial SCC-SP fractionation and passaging increased their relative abundance within the total cell population. Purified SCC-SP cells also exhibited increased clonogenic potential in secondary cultures and enhanced tumorigenicity in vivo. Despite this, SCC-SP cells remained chemotherapeutically sensitive upon ATP-dependent transporter inhibition. Overall, these findings suggest that the existence of ATP transporter-dependent cancer stem-like cells may be relatively common, particularly within established tumours. Future chemotherapeutic strategies should therefore consider coupling identification and targeting of this potential stem cell-like population with standard treatment methodologies
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