615 research outputs found
Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease. CARD15 functions as an intracellular receptor for bacterial components and thus represents an important link between inflammatory bowel disease and innate immunity. Three major CARD15/NOD2 gene mutations have been associated with Crohn's disease in Caucasians in several independent studies. Together, they explain about 20% of the genetic susceptibility for Crohn's disease. Genotype-phenotype analyses demonstrated an association of these mutations with ileum-specific disease, an increased incidence of the fibrostenotic phenotype and an earlier age of disease onset. Beside these associations, no other relationship between the CARD15/NOD2 genotype and disease behavior or response to treatment has been detailed so far. Thus, the clinical impact of knowing the patient's genotype is limited at this time. Screening for CARD15 mutations in order to identify high-risk individuals or to introduce an individualized disease management is therefore currently not recommended. Copyright (C) 2003 S. Karger AG, Basel
Anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: Potential clinical value
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described as specific markers in Crohn's disease and their healthy first-degree relatives. 171 patients with Crohn's disease, their 105 first-degree relatives, 145 patients with ulcerative colitis and 101 first-degree relatives of patients with ulcerative colitis, 50 patients with infectious enterocolitis and 100 healthy controls were tested for ASCA employing the ELISA technique. When compared with the healthy controls (p < 0.0001) and patients with infectious enterocolitis (p < 0.0001) the prevalence of ASCA was significantly increased in patients with Crohn's disease and their first-degree relatives (p < 0.01). Further significant differences concerning the frequency of ASCA within the different groups of our study population were not observed. In particular, ASCA were not found in increased prevalence in infectious enterocolitis. These observations are compatible with a role of ASCA as a marker of genetic predisposition to Crohn's disease. Copyright (C) 2002 S. Karger AG, Basel
Inflammatory bowel disease-specific autoantibodies in HLA-B27-associated spondyloarthropathies: Increased prevalence of ASCA and pANCA
Aims: An association between inflammatory bowel disease (IBD) and spondyloarthropathies (SpA) has repeatedly been reported. The aim of the present study was to investigate whether serologic markers of IBD, e. g. antibodies against Saccharomyces cerevisiae (ASCA), antibodies against exocrine pancreas (PAB) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) are present in HLA-B27-associated SpA. Methods: 87 patients with HLA-B27-positive SpA and 145 controls were tested for ASCA, PAB and pANCA employing ELISA or indirect immunofluorescence, respectively. Antibody-positive patients were interviewed regarding IBD-related symptoms using a standardized questionnaire. Results/Conclusion: When compared to the controls, ASCA IgA but not ASCA IgG levels were significantly increased in patients with SpA, in particular in ankylosing spondylitis (AS) and undifferentiated SpA (uSpA). pANCA were found in increased frequency in patients with SpA whereas PAB were not detected. The existence of autoantibodies was not associated with gastrointestinal symptoms but sustains the presence of a pathophysiological link between bowel inflammation and SpA. Copyright (C) 2004 S. Karger AG, Basel
Quasiperiodic oscillations in a strong gravitational field around neutron stars testing braneworld models
The strong gravitational field of neutron stars in the brany universe could
be described by spherically symmetric solutions with a metric in the exterior
to the brany stars being of the Reissner-Nordstrom type containing a brany
tidal charge representing the tidal effect of the bulk spacetime onto the star
structure. We investigate the role of the tidal charge in orbital models of
high-frequency quasiperiodic oscillations (QPOs) observed in neutron star
binary systems. We focus on the relativistic precession model. We give the
radial profiles of frequencies of the Keplerian (vertical) and radial epicyclic
oscillations. We show how the standard relativistic precession model modified
by the tidal charge fits the observational data, giving estimates of the
allowed values of the tidal charge and the brane tension based on the processes
going in the vicinity of neutron stars. We compare the strong field regime
restrictions with those given in the weak-field limit of solar system
experiments.Comment: 26 pages, 6 figure
A Parametric Study of Erupting Flux Rope Rotation. Modeling the "Cartwheel CME" on 9 April 2008
The rotation of erupting filaments in the solar corona is addressed through a
parametric simulation study of unstable, rotating flux ropes in bipolar
force-free initial equilibrium. The Lorentz force due to the external shear
field component and the relaxation of tension in the twisted field are the
major contributors to the rotation in this model, while reconnection with the
ambient field is of minor importance. Both major mechanisms writhe the flux
rope axis, converting part of the initial twist helicity, and produce rotation
profiles which, to a large part, are very similar in a range of shear-twist
combinations. A difference lies in the tendency of twist-driven rotation to
saturate at lower heights than shear-driven rotation. For parameters
characteristic of the source regions of erupting filaments and coronal mass
ejections, the shear field is found to be the dominant origin of rotations in
the corona and to be required if the rotation reaches angles of order 90
degrees and higher; it dominates even if the twist exceeds the threshold of the
helical kink instability. The contributions by shear and twist to the total
rotation can be disentangled in the analysis of observations if the rotation
and rise profiles are simultaneously compared with model calculations. The
resulting twist estimate allows one to judge whether the helical kink
instability occurred. This is demonstrated for the erupting prominence in the
"Cartwheel CME" on 9 April 2008, which has shown a rotation of \approx 115
degrees up to a height of 1.5 R_sun above the photosphere. Out of a range of
initial equilibria which include strongly kink-unstable (twist Phi=5pi), weakly
kink-unstable (Phi=3.5pi), and kink-stable (Phi=2.5pi) configurations, only the
evolution of the weakly kink-unstable flux rope matches the observations in
their entirety.Comment: Solar Physics, submitte
Production Technology and Competitiveness In the Hungarian Manufacturing Industry
Following the big transformations of the 1990s, enterprise structure and technological level seem to
have become stabilised in Hungary. Under these circumstances it is especially interesting to identify
the elements responsible for competitiveness in general, and the role technology plays in development
in particular, according to managers experienced in production and marketing. This empirical
study â based on in-depth interviews and field research â summarises characteristics of the technological
level in the sectors examined, role of technology and labour in production, effects of foreign
direct investment, relations between competition and firm-level factors determining competitiveness,
and concludes by summing up those most frequently mentioned proposals that should be incorporated
into economic policy according to managers. Main findings indicate that more qualified,
more intensive and cheaper labour can be substituted for high technology. The competitiveness of an
enterprise is not determined by technology alone, but rather by a combination of technology, the parameters
of available labour and the costs of investment increasing productivity. The insufficiency
of inter-company relations, together with a shortage of available assets necessary for investment
constitute the major threat undermining the competitiveness of enterprises in present-day Hungary
Investigating the driving mechanisms of coronal mass ejections
The objective of this investigation was to first examine the kinematics of
coronal mass ejections (CMEs) using EUV and coronagraph images, and then to
make a comparison with theoretical models in the hope to identify the driving
mechanisms of the CMEs. We have studied two CMEs which occurred on 2006 Dec. 17
(CME06) and 2007 Dec. 31 (CME07). The models studied in this work were
catastrophe, breakout, and toroidal instability models. We found that after the
eruption, the accelerations of both events exhibited a drop before increasing
again. Our comparisons with the theories suggested that CME06 can be best
described by a hybrid of the catastrophe and breakout models while CME07 is
most consistent with the breakout model.Comment: 9 pages 7 figure
Multiwavelength Study of M8.9/3B Solar Flare from AR NOAA 10960
We present a multi-wavelength analysis of a long duration white-light solar
flare (M8.9/3B) event that occurred on 4 June 2007 from NOAA AR 10960. The
flare was observed by several spaceborne instruments, namely SOHO/MDI,
Hinode/SOT, TRACE and STEREO/SECCHI. The flare was initiated near a small,
positive-polarity, satellite sunspot at the centre of the AR, surrounded by
opposite-polarity field regions. MDI images of the AR show considerable amount
of changes in a small positive-polarity sunspot of delta configuration during
the flare event. SOT/G-band (4305 A) images of the sunspot also suggest the
rapid evolution of the positive-polarity sunspot with highly twisted penumbral
filaments before the flare event, which were oriented in the counterclockwise
direction. It shows the change in orientation and also remarkable disappearance
of twisted penumbral filaments (~35-40%) and enhancement in umbral area
(~45-50%) during the decay phase of the flare. TRACE and SECCHI observations
reveal the successive activations of two helical twisted structures associated
with this sunspot, and the corresponding brightening in the chromosphere as
observed by the time-sequence images of SOT/Ca II H line (3968 A). The
secondary-helical twisted structure is found to be associated with the M8.9
flare event. The brightening starts 6-7 min prior to the flare maximum with the
appearance of secondary helical-twisted structure. The flare intensity
maximizes as this structure moves away from the AR. This twisted flux-tube
associated with the flare triggering, is found to be failed in eruption. The
location of the flare is found to coincide with the activation site of the
helical twisted structures. We conclude that the activations of successive
helical twists in the magnetic flux tubes/ropes plays a crucial role in the
energy build-up process and triggering of M-class solar flare without a CME.Comment: 22 pages, 12 figures, Accepted for Publication in Solar Physic
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