561 research outputs found
Numerical investigation of the dynamics of linear spin fields on Kerr background I. Late time tails of spin fields
The time evolution of linear fields of spin and on
Kerr black hole spacetimes are investigated by solving the homogeneous
Teukolsky equation numerically. The applied numerical setup is based on a
combination of conformal compactification and the hyperbolic initial value
problem. The evolved basic variables are expanded in terms of spin-weighted
spherical harmonics which allows us to evaluate all the angular derivatives
analytically, whereas the evolution of the expansion coefficients, in the
time-radial section, is determined by applying the method of lines implemented
in a fourth order accurate finite differencing stencil. Concerning the
initialization, in all of our investigations single mode excitations---either
static or purely dynamical type initial data---are applied. Within this setup
the late time tail behavior is investigated. Due to the applied conformal
compactification the asymptotic decay rates are determined at three
characteristic locations---in the domain of outer communication, at the event
horizon and at future null infinity---simultaneously. Recently introduced new
type of `energy' and `angular momentum' balance relations are also applied in
order to demonstrate the feasibility and robustness of the developed numerical
schema, and also to verify the proper implementation of the underlying
mathematical model.Comment: 38 pages, 5 figures, typos correcte
On a strong version of the Kepler conjecture
We raise and investigate the following problem that one can regard as a very
close relative of the densest sphere packing problem. If the Euclidean 3-space
is partitioned into convex cells each containing a unit ball, how should the
shapes of the cells be designed to minimize the average surface area of the
cells? In particular, we prove that the average surface area in question is
always at least 13.8564... .Comment: 9 page
A glükokortikoidok hatását és metabolizmusát befolyásoló gén-polimorfizmusok patofiziológiai szerepének vizsgálata = Pathophysiological significance of gene polymorphisms affecting glucocorticoid action and metabolism
A HSD11B1 gĂ©nen in silico kutatásainkkal azonosĂtott 65 polimorfizmus közĂĽl - transzkripciĂłs faktorok kötĹ‘helyein elhelyezkedĂ©sĂĽk alapján - 12 polimorfizmust rĂ©szletesen vizsgáltunk Ă©s meghatároztuk populáciĂł-szintű gyakoriságukat. A vizsgált 12 polimorfizmus közĂĽl a rs4844880 polimorf allĂ©l bizonyult kiemelten jelentĹ‘snek; a polimorfizmus hordozása kedvezĹ‘bb csont ásványianyag tartalommal (BMC) társult Ă©s jelenlĂ©te esetĂ©n Cushing-szindrĂłmás betegekben magasabb szĂ©rum kortizol Ă©s osteokalcin koncentráciĂłkat detektáltunk. Kimutattuk, hogy a polimorf allĂ©lt tartalmazĂł vektorral transzfektált Hela sejtek csökkent luciferáz aktivitást mutattak, ami magyarázza a rs4844880 allĂ©l hordozás csontanyagcserĂ©re kifejtett kedvezĹ‘ hatását. A GR gĂ©n 4 polimorfizmusának (Bcl1, N363S, ER22/23EK Ă©s A3669G) vizsgálatával kimutattuk, hogy a Bcl1 polimorfizmus jelenlĂ©te csökkent BMC Ă©rtĂ©kkel társul Cushing-szindrĂłmás betegekben. Kimutattuk továbbá, hogy várandĂłs nĹ‘kben a Bcl1 polimorfizmus hordozása kockázati tĂ©nyezĹ‘ a HELLP szindrĂłma kialakulásában, Ă©s az ER22/23EK polimorfizmus jelenlĂ©te várandĂłs nĹ‘kben csökkenti a graviditás alatti testsĂşly növekedĂ©s kockázatát. Mindezek az eredmĂ©nyek Ăşj adatokkal egĂ©szĂtik ki a glĂĽkokortikoidok iránti Ă©rzĂ©kenysĂ©g pathofiziolĂłgiai jelentĹ‘sĂ©gĂ©t, melyet nagyrĂ©szt genetikai tĂ©nyezĹ‘k, köztĂĽk elsĹ‘sorban a HSD11B1 Ă©s GR gĂ©nek variánsai határoznak meg. | Of the 65 polymorphisms identified in the HSD11B1 gene using our in silico analysis, 12 were further investigated based on their critical locations in sites which bind transcription factors, and their allelic frequencies were determined in healthy subjects. Of these 12 polymorphic alleles, the rs4844880 proved to be particularly important, because this polymorphic allele was associated with better bone mineral content (BMC) and, in patients with Cushing’s syndrome, with higher serum cortisol and osteocalcin concentrations. Hela cells transfected with this polymorphic variant showed decreased luciferase activity compared to those transfected with the wild-type variant, thus explaining the beneficial effect of the rs4844880 polymorphism on bone metabolism. Studies on the 4 polymorphisms of the GR gene (Bcl1, N363S, ER22/23EK and A3669G) indicated that the polymorphic Bcl1 allele was associated with a lower bone mineral content in patients with Cushing’s syndrome. In addition, we showed that the presence of this allele is a risk factor for HELLP syndrome in pregnant women, and that carriers of the ER22/23/EK polymorphism have a lower risk for weight gain during pregnancy. All these finding provide novel data on the pathophysiologic significance of glucocorticoid sensitivity, determined by genetic factors mainly including the HSD11B1 and GR gene variants
Estimation of influential points in any data set from coefficient of determination and its leave-one-out cross-validated counterpart
Coefficient of determination (R2) and its leave-one-out cross-validated analogue (denoted by Q2 or Rcv 2) are the most frequantly published values to characterize the predictive performance of models. In this article we use R2 and Q2 in a reversed aspect to determine uncommon points, i.e. influential points in any data sets. The term (1 - Q2)/(1 - R2) corresponds to the ratio of predictive residual sum of squares and the residual sum of squares. The ratio correlates to the number of influential points in experimental and random data sets. We propose an (approximate) F test on (1 - Q2)/(1 - R2) term to quickly pre-estimate the presence of influential points in training sets of models. The test is founded upon the routinely calculated Q2 and R2 values and warns the model builders to verify the training set, to perform influence analysis or even to change to robust modeling. Graphical Abstract: [Figure not available: see fulltext.] © 2013 Springer Science+Business Media Dordrecht
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