Studies in Law. Research Papers

Słowo wstępne: "Drodzy Czytelnicy, Prezentujemy Państwu kolejny numer naszego periodyku. W tym bogatym zbiorze wypowiedzi przedstawicieli doktryny prawa i praktyki prawniczej znalazło się miejsce dla prac autorów z różnych dziedzin prawa. Analizowane zagadnienia odnoszą się w szczególności do problematyki prawa konstytucyjnego, prawa cywilnego, prawa pracy, prawa karnego. Zgromadziliśmy cenne spostrzeżenia autorów z różnych ośrodków akademickich – tak z Polski, jak i z zagranicy. Obok interesujących artykułów naukowych oraz glos przedstawiamy też niemałą liczbę innych tekstów, przede wszystkim recenzji publikacji naukowych i sprawozdań pokonferencyjnych. Mamy nadzieję, że ten, jak i przyszłe numery czasopisma stanowić będą dla Państwa interesującą lekturę, skłaniającą do refleksji nad poruszanymi tematami i prowokującą do tworzenia kolejnych prac naukowych. Liczymy, że zechcą Państwo publikować je – jak do tej pory – na łamach czasopisma „Studia Prawnicze. Rozprawy i Materiały”. Życzę inspirującej lektury!"(...

Trendy innowacyjne w europejskich portach morskich w obliczu pandemii COVID-19

The implementation of innovations is one of the primary areas of activity within modern enterprises and their response to environmental changes. It is also an important and current research issue concerning seaports. Innovations may have a different nature, and practice shows that their implementation is in line with certain trends that set the directions for the development of innovative solutions throughout the world. This study aims to identify the most important technological innovations implemented in European seaports and determine whether they are in line with global innovation trends. It was also a priority to assess the impact of the COVID-19 pandemic on the direction of innovation processes implemented within the ports. The author carried out two steps of research. The first one was based on secondary sources (publications and data from the Internet) and the second on primary sources (surveys conducted in March and October 2020). The analysis of data from secondary sources made it possible to identify the most significant global innovation trends in seaports. The study of data from surveys carried out with the managers of port companies allowed the author to conclude that the COVID-19 pandemic in the analyzed period of the year 2020 had little impact on the European seaports' innovative activities, which go in line with global innovation trends. It did not stop the innovation processes in those ports, causing only slight delays in implementing some scheduled innovative projects. It also did not influence the types of such projects carried out at that time or their significance. We can see that it also had no adverse effect on the emergence of new innovative trends in the examined enterprises. During the pandemic, European seaports made efforts to ensure the continued implementation of innovations in line with the established plans

Preparation of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides and Their Experimental and Computational Biological Studies

Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides constitute a novel class of heterocyclic compounds with broad biological activity, including anticancer properties. Investigated in this study, MM-compounds (MM134, MM136, MM137, and MM139) exhibited cytotoxic and proapoptotic activity against cancer cell lines (BxPC-3, PC-3, and HCT-116) in nanomolar concentrations without causing cytotoxicity in normal cells (L929 and WI38). In silico predictions indicate that tested compounds exhibit favorable pharmacokinetic profiles and may exert anticancer activity through the inhibition of BTK kinase, the AKT-mTOR pathway and PD1-PD-L1 interaction. Our findings point out that these sulfonamide derivatives may constitute a source of new anticancer drugs after optimization

Malnutrition, Sarcopenia, and Malnutrition-Sarcopenia Syndrome in Older Adults with COPD

Purpose: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the world population. In addition to airflow obstruction, COPD is associated with multiple systemic manifestations, including impaired nutritional status or malnutrition and changes in body composition (low muscle mass, LMM). Poor nutritional status and sarcopenia in subjects with COPD leads to a worse prognosis and increases health-related costs. Data from previous studies indicate that 30–60% of subjects with COPD are malnourished, 20–40% have low muscle mass, and 15–21.6% have sarcopenia. This study aimed to assess the prevalence of malnutrition, sarcopenia, and malnutrition-sarcopenia syndrome in elderly subjects with COPD and investigate the relationship between COPD severity and these conditions.Patients and methods: A cross-sectional study involving 124 patients with stable COPD, aged ≥60, participating in a stationary pulmonary rehabilitation program. Nutritional status was assessed following the Global Leadership Initiative on Malnutrition (GLIM) criteria and sarcopenia with the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. The results of pulmonary function tests and exercise capacity were obtained from the hospital database. Results: 22.6% of participants had malnutrition according to the GLIM criteria. Subjects with malnutrition had lower gait speed (p = 0.0112) and worse results of the Six Minute Walk Test. Sixteen participants (12.9%) had sarcopenia; 12 subjects with sarcopenia had concomitant malnutrition. The prevalence of severe and very severe obstruction (GOLD3/GOLD4) was 91.7%. It was significantly higher in patients with malnutrition-sarcopenia syndrome. Conclusions: Malnutrition was found in nearly one out of four subjects with COPD, while sarcopenia was one out of seven patients. About 10% of our study sample had malnutrition-sarcopenia syndrome. The prevalence of severe and very severe obstruction was significantly higher in patients with malnutrition-sarcopenia syndrome

Socioeconomic risk factors of poor nutritional status in Polish elderly population : the results of PolSenior2 study

Poor nutritional status (PNS) threatens successful aging. Identifying potentially modifiable predictors of PNS is essential for elaborating a preventive strategy for the population at risk. To assess the prevalence of PNS in the Polish elderly population and analyze its socioeconomic correlates based on the data from the nationwide PolSenior2 project. Special emphasis was put on potentially modifiable factors among the identified PNS predictors. Nutritional status was assessed in 5698 community-dwelling older adults with the Mini Nutritional Assessment–Short Form. We evaluated the effect of age, sex, level of education, marital status, place of residence, subjective loneliness, and self-reported poverty on the nutritional status of the studied subjects. PNS was found in 25.3% of studied subjects (27.7% women and 21.9% men; p < 0.001). Female sex, older age, unmarried status (in men), subjective loneliness, and self-reported poverty were independent correlates of PNS. The two last above-mentioned predictors were identified as potentially modifiable. Based on our results, we recommend preventive interventions (e.g., performing regular screening), particularly in unmarried (men), poorly educated individuals, self-reporting poverty, complaining of loneliness, and the oldest old. PNS preventive strategies should include social support (both emotional and instrumental) to reduce the effect of poverty and subjective loneliness