Interstitial cells of Cajal — systematic review

This paper reviews the distribution of interstitial cells of Cajal (ICC) in the human gastro­intestinal (GI) tract, based on ultrastructural and immunohistochemical evidence. The distribution and morphology of ICC at each level of the normal GI tracts is addressed from the perspective of their functional significance. Alterations of ICC reported in as well as in GI stromal tumours are reviewed, with emphasis on the place of ICC in the pathophysiology of disease

The surgical treatment of rectal cancer in Poland. The findings of a multi-center observational study by the Polish Society of Surgical Oncology (PSSO-01)

Introduction. PSSO-01, a Polish prospective multi-center project on rectal cancer, started in 2016 with participation on a voluntary basis. This study evaluates the early outcome of the surgical treatment of rectal cancer in Poland according to hospital volume. Material and methods. The dataset derives from 17 clinical centers registered in the PSSO-01 study. From 2016 to 2020, the data of 1,607 patients were collected. Taking into account the number of patients enrolled in the study, the centers were divided into three categories: high volume, medium volume, and low volume. Nominal variables were compared between different categories of centers using the chi-square test. The STROBE guidelines were used to guarantee the reporting of this observational study. Results. More patients with metastatic disease were operated on in the low volume centers (p = 0.020). Neoadjuvant treatment was used in 35%, 52%, and 66% of patients operated on in low, medium, and high volume centers respectively (p < 0.001). Laparoscopic resection in medium volume centers was performed more often than in other centers (p < 0.001). The total rate of postoperative complications related to high, medium, and low centers was 22%, 26%, 18% (p = 0.044). One year following surgery, a stoma was present in 63% of patients. A defunctioning stoma following anterior resection was reversed in only 55% of patients. Anastomotic leakage was the main reason for a non-reversal diverting stoma. Conclusions. The representation of low volume centers in the PSSO-01 study was understated. However, the outcomes may show the actual situation of surgical treatment of rectal cancer in high and medium volume centers in Poland

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

BACKGROUND Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and inter-leukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn’s disease. Ustekinumab was also evaluated as subcutaneous maintenance therapy. METHODS We randomly assigned patients to receive a single intravenous dose of ustekinumab (either 130 mg or approximately 6 mg per kilogram of body weight) or placebo in two induction trials. The UNITI-1 trial included 741 patients who met the criteria for primary or secondary nonresponse to tumor necrosis factor (TNF) antagonists or had unacceptable side effects. The UNITI-2 trial included 628 patients in whom conventional therapy failed or unacceptable side effects occurred. Patients who completed these induction trials then participated in IM-UNITI, in which the 397 patients who had a response to ustekinumab were randomly assigned to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 8 weeks or every 12 weeks) or placebo. The primary end point for the induction trials was a clinical response at week 6 (defined as a decrease from baseline in the Crohn’s Disease Activity Index [CDAI] score of ≥100 points or a CDAI score <150). The primary end point for the maintenance trial was remission at week 44 (CDAI score <150). RESULTS The rates of response at week 6 among patients receiving intravenous ustekinumab at a dose of either 130 mg or approximately 6 mg per kilogram were significantly higher than the rates among patients receiving placebo (in UNITI-1, 34.3%, 33.7%, and 21.5%, respectively, with P≤0.003 for both comparisons with placebo; in UNITI-2, 51.7%, 55.5%, and 28.7%, respectively, with P<0.001 for both doses). In the groups receiving maintenance doses of ustekinumab every 8 weeks or every 12 weeks, 53.1% and 48.8%, respectively, were in remission at week 44, as compared with 35.9% of those receiving placebo (P = 0.005 and P = 0.04, respectively). Within each trial, adverse-event rates were similar among treatment groups. CONCLUSIONS Among patients with moderately to severely active Crohn’s disease, those receiving intravenous ustekinumab had a significantly higher rate of response than did those receiving placebo. Subcutaneous ustekinumab maintained remission in patients who had a clinical response to induction therapy. (Funded by Janssen Research and Development; ClinicalTrials.gov numbers, NCT01369329, NCT01369342, and NCT01369355.

Hydraulic fracturing in systems of geothermal energy utilization (EGS, HDR)

This work reviews possibility of using the heat from impermeable hot dry rock formations. Significant development in hydraulic fracturing technique in a last few years have a result in making accessible sources of energy from impermeable rocks, including hot dry rocks, which wasn't possible before. This paper presents the idea of utilization the EGS system which is based on forced and closed water circulation in a natural and permeable geological reservoir or in a reservoir, where the fractured zone was created artificially by for example hydraulic fracturing treatment. The article shows also an examples of recent EGS/HDR systems around the world

Assessment of Nitrogen Inputs into Hunt River by Onsite Wastewater Treatment Systems via SWAT Simulation

Nonpoint source nitrogen pollution is difficult to effectively model in groundwater systems. This study aims to elucidate anthropogenic nonpoint source pollution discharging into Potowomut Pond and ultimately Narragansett Bay. Hydrologic modeling with Soil and Water Assessment Tool (SWAT) and SWAT Calibration and Uncertainty Program (SWAT-CUP) was used to simulate streamflow and nitrogen levels in the Hunt River with and without onsite wastewater treatment systems (OWTS). The objective of this study was to determine how input of OWTS data impacts nitrogen loading into the Hunt River Watershed in Rhode Island, USA. The model was simulated from 2006 to 2014, calibrated from 2007 to 2011 and validated from 2012 to 2014. Observed streamflow data was sourced from a US Geological Survey gauge and nitrogen loading data from University of Rhode Island Watershed Watch (URIWW). From the results, adding OWTS data to the SWAT simulation produced a better calibration and validation fit for total fit (Nash–Sutcliffe Efficiency (NSE) = 0.50 calibration, 0.78 validation) when compared with SWAT simulation without OWTS data (NSE = −1.3 calibration, −6.95) validation

Synthesis of dye-sensitized solar cells. Efficiency cells as a thickness of titanium dioxide

Defying the influence of the thickness of TiO2 efficiency of dye-sensitized solar cell. It was confirmed that the compatibility of printed layers with the parameters closely related with the DSSC. It was found that the increase in thickness of the titanium dioxide layer, increases the distance between the electrodes, determined by the thickness of the Surlyn foil. With the rise of thickness of dyed layer of TiO2 established decrease in the value of its transmittance. Greatest transparency and aesthetic value obtained for photovoltaic modules with a single layer of titanium dioxide. The improved performance efficiency and preferred yields maximum power were noticed and exhibited by the cells covered with three layers of TiO2. It was established that the behaviour of economic efficiency in the production process, provides a range of cells with two layers of oxide, showing a similar performance and greater transparency

Some remarks on utilization of kitchen organic waste by vermicomposting

W pracy przeprowadzono analizę odpadów produkowanych przez czteroosobową rodzinę zamieszkującą dom na obrzeżach miasta. Szczególną uwagę zwracano na kuchenne odpady organiczne. Podsumowując kilkuletnie obserwacje nad wermikompostowaniem tej grupy odpadów, zwrócono uwagę na zasadność segregowania odpadów organicznych „u źródła” w kontekście możliwości ich wykorzystania do produkcji wermikompostu w „dżdżownicowych skrzynkach ekologicznych”. W pracy porównywano proces wermikompostowania z użyciem dwóch gatunków dżdżownic: Eisenia fetida (Sav.) i Dendrobaena veneta Rosa. Rozważono również kilka ekonomiczno-organizacyjnych aspektów wprowadzania innowacyjnych „skrzynek ekologicznych” do codziennej praktyki.This paper analyzes the waste produced by a family of four living in a house on the edge of the city. Particular attention was paid to the kitchen organic waste. Several years of observations on vermicomposting of such waste have been summarized. Separating of organic waste on site is important in the context of its use for the production of vermicompost in “earthworm ecological boxes”. The study compared the vermicomposting process using two species of earthworms: Eisenia fetida (Sav.) and Dendrobaena veneta Rosa. Several economical and organizational aspects of introducing innovative “ecological boxes” for daily practice was also considered