60 research outputs found
Recommended from our members
NRC support for the Kalinin (VVER) probabilistic risk assessment
The US Nuclear Regulatory Commission (NRC) and the Federal Nuclear and Radiation Safety Authority of the Russian Federation have been working together since 1994 to carry out a probabilistic risk assessment (PRA) of a VVER-1000 in the Russian Federation. This was a recognition by both parties that this technology has had a profound effect on the discipline of nuclear reactor safety in the West and that the technology should be transferred to others so that it can be applied to Soviet-designed plants. The NRC provided funds from the Agency for International Development and technical support primarily through Brookhaven National Laboratory and its subcontractors. The latter support was carried out through workshops, by documenting the methodology to be used in a set of guides, and through periodic review of the technical activity. The result of this effort to date includes a set of procedure guides, a draft final report on the Level 1 PRA for internal events (excluding internal fires and floods), and progress reports on the fire, flood, and seismic analysis. It is the authors belief that the type of assistance provided by the NRC has been instrumental in assuring a quality product and transferring important technology for use by regulators and operators of Soviet-designed reactors. After a thorough review, the report will be finalized, lessons learned will be applied in the regulatory and operational regimes in the Russian Federation, and consideration will be given to supporting a containment analysis in order to complete a simplified Level 2 PRA
Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature
Progress in the understanding of the biology of perinatal tissues has contributed to the
breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely
birth-associated tissues, cells, and secreted factors. The significant knowledge acquired
in the past two decades, along with the increasing interest in perinatal derivatives, fuels
an urgent need for the precise identification of PnD and the establishment of updated
consensus criteria policies for their characterization. The aim of this review is not to go into detail on preclinical or clinical trials, but rather we address specific issues
that are relevant for the definition/characterization of perinatal cells, starting from an
understanding of the development of the human placenta, its structure, and the different
cell populations that can be isolated from the different perinatal tissues. We describe
where the cells are located within the placenta and their cell morphology and phenotype.
We also propose nomenclature for the cell populations and derivatives discussed herein.
This review is a joint effort from the COST SPRINT Action (CA17116), which broadly
aims at approaching consensus for different aspects of PnD research, such as providing
inputs for future standards for the processing and in vitro characterization and clinical
application of PnD.Austrian Science Fund (FWF)
DOC 31-B26Medical University GrazUniversita Cattolica del Sacro CuorePRIN 2017 program of Italian Ministry of Research and University (MIUR)
2017RSAFK7Ministry of Health, Italy
GR-2018-12366992Slovenian Research Agency - Slovenia
P3-0108MRIC UL
IP-0510Plan Estatal de Investigacion Cientifica y Tecnica y de InnovacionISCIII Subdireccion General de Evaluacion y Fomento de la InvestigacionMinisterio de Economia y Competitividad, Spain
PI16/01642European Union (EU)European Community (EC)German Research Foundation (DFG)
GE-2223/2-
PlGF Repairs Myocardial Ischemia through Mechanisms of Angiogenesis, Cardioprotection and Recruitment of Myo-Angiogenic Competent Marrow Progenitors
Despite preclinical success in regenerating and revascularizing the infarcted heart using angiogenic growth factors or bone marrow (BM) cells, recent clinical trials have revealed less benefit from these therapies than expected.We explored the therapeutic potential of myocardial gene therapy of placental growth factor (PlGF), a VEGF-related angiogenic growth factor, with progenitor-mobilizing activity.Myocardial PlGF gene therapy improves cardiac performance after myocardial infarction, by inducing cardiac repair and reparative myoangiogenesis, via upregulation of paracrine anti-apoptotic and angiogenic factors. In addition, PlGF therapy stimulated Sca-1(+)/Lin(-) (SL) BM progenitor proliferation, enhanced their mobilization into peripheral blood, and promoted their recruitment into the peri-infarct borders. Moreover, PlGF enhanced endothelial progenitor colony formation of BM-derived SL cells, and induced a phenotypic switch of BM-SL cells, recruited in the infarct, to the endothelial, smooth muscle and cardiomyocyte lineage.Such pleiotropic effects of PlGF on cardiac repair and regeneration offer novel opportunities in the treatment of ischemic heart disease
Measurements of K, Λ , and production in 120 GeV / c p + C interactions
This paper presents multiplicity measurements of K0S, Λ, and ¯Λ produced in 120 GeV/c proton-carbon interactions. The measurements were made using data collected at the NA61/SHINE experiment during two different periods. Decays of these neutral hadrons impact the measured π+, π−, p and ¯p multiplicities in the 120 GeV/c proton-carbon reaction, which are crucial inputs for long-baseline neutrino experiment predictions of neutrino beam flux. The double-differential multiplicities presented here will be used to more precisely measure charged-hadron multiplicities in this reaction, and to reweight neutral hadron production in neutrino beam Monte Carlo simulations
Measurements of , , , , and production in 120 GeV/ p + C interactions
This paper presents multiplicity measurements of charged hadrons produced in
120 GeV/ proton-carbon interactions. The measurements were made using data
collected at the NA61/SHINE experiment during two different data-taking
periods, with increased phase space coverage in the second configuration due to
the addition of new subdetectors. Particle identification via was
employed to obtain double-differential production multiplicities of ,
, , , and . These measurements are presented as a
function of laboratory momentum in intervals of laboratory polar angle covering
the range from 0 to 450 mrad. They provide crucial inputs for current and
future long-baseline neutrino experiments, where they are used to estimate the
initial neutrino flux
Measurements of , , and spectra in Ar+Sc collisions at 13 to 150 GeV/
The NA61/SHINE experiment at the CERN Super Proton Synchrotron studies the
onset of deconfinement in strongly interacting matter through a beam energy
scan of particle production in collisions of nuclei of varied sizes. This paper
presents results on inclusive double-differential spectra, transverse momentum
and rapidity distributions and mean multiplicities of , ,
and produced in Ar+Sc collisions at beam momenta of
13, 19, 30, 40, 75 and 150 GeV/. The analysis uses the 10%
most central collisions, where the observed forward energy defines centrality.
The energy dependence of the / ratios as well as of inverse
slope parameters of the transverse mass distributions are placed in
between those found in inelastic + and central Pb+Pb collisions. The
results obtained here establish a system-size dependence of hadron production
properties that so far cannot be explained either within statistical (SMES,
HRG) or dynamical (EPOS, UrQMD, PHSD, SMASH) models
meson production in inelastic p+p interactions at 31, 40 and 80 GeV/c beam momentum measured by NA61/SHINE at the CERN SPS
Measurements of meson production via its decay mode
in inelastic interactions at incident projectile momenta of 31,
40 and 80 GeV/ ( and GeV, respectively) are
presented. The data were recorded by the NA61/SHINE spectrometer at the CERN
Super Proton Synchrotron. Double-differential distributions were obtained in
transverse momentum and rapidity. The mean multiplicities of mesons
were determined to be at
31 GeV/, at 40
GeV/ and at 80
GeV/. The results on production are compared with model
calculations (Epos1.99, SMASH 2.0 and PHSD) as well as with published data from
other experiments.Comment: arXiv admin note: substantial text overlap with arXiv:2106.0753
Measurement of Hadron Production in -C Interactions at 158 and 350 GeV/c with NA61/SHINE at the CERN SPS
We present a measurement of the momentum spectra of , K,
p, , and K produced in interactions of
negatively charged pions with carbon nuclei at beam momenta of 158 and 350
GeV/c. The total production cross sections are measured as well. The data were
collected with the large-acceptance spectrometer of the fixed target experiment
NA61/SHINE at the CERN SPS. The obtained double-differential - spectra
provide a unique reference data set with unprecedented precision and large
phase-space coverage to tune models used for the simulation of particle
production in extensive air showers in which pions are the most numerous
projectiles
Search for the critical point of strongly-interacting matter in Ar + Sc collisions at 150A Ge V /c using scaled factorial moments of protons
The critical point of dense, strongly interacting matter is searched for at the CERN SPS in Ar + Sc collisions at 150A Ge V /c. The dependence of second-order scaled factorial moments of proton multiplicity distribution on the number of subdivisions of transverse momentum space is measured. The intermittency analysis is performed using both transverse momentum and cumulative transverse momentum. For the first time, statistically independent data sets are used for each subdivision number. The obtained results do not indicate any statistically significant intermittency pattern. An upper limit on the fraction of correlated proton pairs and the power of the correlation function is obtained based on a comparison with the Power-law Model developed for this purpose
- …