Folyami hajózás és a magyarországi gabonaexport

Az árutermelésre áttért mezÅ‘gazdaság közel másfél évszázada alatt bebizonyosodott, hogy a megtermelt terményfelesleg az ország gazdaságföldrajzi „bezártsága†miatt nem versenyképes a tengeri kijutással rendelkezÅ‘ országok gabonájával szemben. Atengeri kikötÅ‘höz vezetÅ‘ olcsó vízi utat máig sem sikerült megteremteni, és a magyar gabona jelenleg is csak a világpiaci árnál alacsonyabb áron értékesíthetÅ‘. Afolyók vízjárástól független hajózhatósága azok belépcsÅ‘zésével valósítható meg. ------------------------------------------- Over the one and a half centuries since agriculture shifted from self-sufficiency to producing marketable goods, it has been proven that the surplus produce – due to the country’s geographical isolation – cannot compete against the cereal of countries with access to seas and oceans. We still have not been able to create a cheap water route to a seaport, and Hungarian cereals can still only be sold below world market prices. To make rivers navigable irrespective of the changes to their water levels, weirs are needed.gazdaságföldrajz, bezártság, belvízi hajózás, vízlépcsÅ‘k, eco-geography, isolation, inland navigation, weirs, Agricultural and Food Policy, International Relations/Trade,

The Drug Candidate BGP-15 Delays the Onset of Diastolic Dysfunction in the Goto-Kakizaki Rat Model of Diabetic Cardiomyopathy

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Folyami hajózás és a magyarországi gabonaexport

Az árutermelésre áttért mezőgazdaság közel másfél évszázada alatt bebizonyosodott, hogy a megtermelt terményfelesleg az ország gazdaságföldrajzi „bezártsága” miatt nem versenyképes a tengeri kijutással rendelkező országok gabonájával szemben. Atengeri kikötőhöz vezető olcsó vízi utat máig sem sikerült megteremteni, és a magyar gabona jelenleg is csak a világpiaci árnál alacsonyabb áron értékesíthető. Afolyók vízjárástól független hajózhatósága azok belépcsőzésével valósítható meg. ------------------------------------------- Over the one and a half centuries since agriculture shifted from self-sufficiency to producing marketable goods, it has been proven that the surplus produce – due to the country’s geographical isolation – cannot compete against the cereal of countries with access to seas and oceans. We still have not been able to create a cheap water route to a seaport, and Hungarian cereals can still only be sold below world market prices. To make rivers navigable irrespective of the changes to their water levels, weirs are needed

Effect of broth from meat of linseed‐fed cattle on glucose‐stimulated insulin release in healthy male volunteers

Polyunsaturated fatty acid consumption has been shown to improve insulin sensitivity. We studied if administration of broth with beef meat enriched with polyunsaturated fatty acids influenced glucose-stimulated insulin release in healthy male volunteers. Broth was made either from cattles undergone dietary supplementation with lightly bruised whole linseed in addition to feeding ad libitum on grass silage (test meal) or from those fed grass silage alone (control meal). Oral glucose tolerance tests (OGTT) were performed in patients after a 6-day period of eating 300 ml broth containing 100 g meat once a day in addition to their otherwise normal mixed nourishment. During OGTT, blood samples were taken for blood glucose level and plasma insulin immunoreactivity before and 15, 30, 60, 90, 120, and 180 min after the glucose load. Glucose-stimulated maximum increase in plasma insulin immunoreactivity was 42 ± 6.6 and 81 ± 7.4 mU/ml (p < 0.05) after the test and the control meals, respectively. However, both fasting and postload blood glucose levels were the same after either meal period. The results suggest an insulin-sensitizing effect of food produced from beef cattle maintained on linseed diet in healthy human volunteers.K

Cardioprotective Role of BGP-15 in Ageing Zucker Diabetic Fatty Rat (ZDF) Model: Extended Mitochondrial Longevity

Impaired mitochondrial function is associated with several metabolic diseases and health conditions, including insulin resistance and type 2 diabetes (T2DM), as well as ageing. The close relationship between the above-mentioned diseases and cardiovascular disease (CVD) (diabetic cardiomyopathy and age-related cardiovascular diseases) has long been known. Mitochondria have a crucial role: they are a primary source of energy produced in the form of ATP via fatty acid oxidation, tricarboxylic acid (TCA) cycle, and electron transport chain (ETC), and ATP synthase acts as a key regulator of cardiomyocyte survival. Mitochondrial medicine has been increasingly discussed as a promising therapeutic approach in the treatment of CVD. It is well known that vitamin B3 as an NAD+ precursor exists in several forms, e.g., nicotinic acid (niacin) and nicotinamide (NAM). These cofactors are central to cellular homeostasis, mitochondrial respiration, ATP production, and reactive oxygen species generation and inhibition. Increasing evidence suggests that the nicotinic acid derivative BGP-15 ((3-piperidine-2-hydroxy-1-propyl)-nicotinic amidoxime) improves cardiac function by reducing the incidence of arrhythmias and improves diastolic function in different animal models. Our team has valid reasons to assume that these cardioprotective effects of BGP-15 are based on its NAD+ precursor property. Our hypothesis was supported by an animal experiment where ageing ZDF rats were treated with BGP-15 for one year. Haemodynamic variables were measured with echocardiography to detect diabetic cardiomyopathy (DbCM) and age-related CVD as well. In the ZDF group, advanced HF was diagnosed, whereas the BGP-15-treated ZDF group showed diastolic dysfunction only. The significant difference between the two groups was supported by post-mortem Haematoxylin and eosin (HE) and Masson&rsquo;s trichrome staining of cardiac tissues. Moreover, our hypothesis was further confirmed by the significantly elevated Cytochrome c oxidase (MTCO) and ATP synthase activity and expression detected with ELISA and Western blot analysis. To the best of our knowledge, this is the first study to demonstrate the protective effect of BGP-15 on cardiac mitochondrial respiration in an ageing ZDF model

Long Term Osmotic Mini Pump Treatment with Alpha-MSH Improves Myocardial Function in Zucker Diabetic Fatty Rats

The present investigation evaluates the cardiovascular effects of the anorexigenic mediator alpha-melanocyte stimulating hormone (MSH), in a rat model of type 2 diabetes. Osmotic mini pumps delivering MSH or vehicle, for 6 weeks, were surgically implanted in Zucker Diabetic Fatty (ZDF) rats. Serum parameters, blood pressure, and weight gain were monitored along with oral glucose tolerance (OGTT). Echocardiography was conducted and, following sacrifice, the effects of treatment on ischemia/reperfusion cardiac injury were assessed using the isolated working heart method. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was measured to evaluate levels of oxidative stress, and force measurements were performed on isolated cardiomyocytes to determine calcium sensitivity, active tension and myofilament co-operation. Vascular status was also evaluated on isolated arterioles using a contractile force measurement setup. The echocardiographic parameters ejection fraction (EF), fractional shortening (FS), isovolumetric relaxation time (IVRT), mitral annular plane systolic excursion (MAPSE), and Tei-index were significantly better in the MSH-treated group compared to ZDF controls. Isolated working heart aortic and coronary flow was increased in treated rats, and higher Hill coefficient indicated better myofilament co-operation in the MSH-treated group. We conclude that MSH improves global heart functions in ZDF rats, but these effects are not related to the vascular status