A study on the equilibrium reaction of benzaldehyde and sodium bisulphite by in situ Fourier transform IR spectroscopy

The addition of sodium bisulphite to benzaldehyde was monitored at different conditions by in situ Fourier transform IR spectroscopy and the equilibrium constant was determined

Porszennyezés vizsgálata Miskolc városában és környékén

Miskolc város porszennyezettségét becsültük meg falevelek alapján. Különösen a nehézfémek mennyiségét figyeltük meg a mintákban a mintavételi területek összehasonlításával. Vizsgálatunk célja, annak megállapítása volt, hogy milyen összefüggés van a porminták összetétele és az emberi tevékenységek között, például ipari tevékenység. A porszennyezés a levelek felületén megülepedő por elemösszetétele alapján történt. A város területéhez közel eső Lillafüred, Tapolca, és a város területén lévő Népkert helyszínein 5 területről származó minták szolgáltak információval.BSc/BABiológiag

Diabetes Mellitus a prevenció és a gondozás tükrében

A diabetes mellitus bemutatása a legfontosabb szempontok szerint, illetve kihangsúlyozva a prevenciót és a gondozást.BSc/BAnépegészségügyimagyarnappal

The Role of Exosomes in Cancer Progression

Early detection, characterization and monitoring of cancer are possible by using extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples. They play a role in intercellular communication contributing to cell growth, differentiation and survival, thereby affecting the formation of tumor microenvironments and causing metastases. EVs were discovered more than seventy years ago. They have been tested recently as tools of drug delivery to treat cancer. Here we give a brief review on extracellular vesicles, exosomes, microvesicles and apoptotic bodies. Exosomes play an important role by carrying extracellular nucleic acids (DNA, RNA) in cell-to-cell communication causing tumor and metastasis development. We discuss the role of extracellular vesicles in the pathogenesis of cancer and their practical application in the early diagnosis, follow up, and next-generation treatment of cancer patients

Prostaglandin E2, a Postulated Mediator of Neurovascular Coupling, at Low Concentrations Dilates Whereas at Higher Concentrations Constricts Human Cerebral Parenchymal Arterioles

There is considerable controversy regarding the vasoactive action of prostaglandin E2 (PGE2). On the one hand, indirect evidence implicates that astrocytic release of PGE2 contributes to neurovascular coupling responses mediating functional hyperemia in the brain. On the other hand, overproduction of PGE2 was also reported to contribute to cerebral vasospasm associated with subarachnoid hemorrhage. The present study was conducted to resolve this controversy by determining the direct vasoactive effects of PGE2 in resistance-sized human cerebral parenchymal arterioles. To achieve this goal PGE2-induced isotonic vasomotor responses were assessed in parenchymal arterioles isolated from fronto-temporo-parietal cortical tissues surgically removed from patients and expression of PGE2 receptors were examined. In functionally intact parenchymal arterioles lower concentrations of PGE2 (from 10-8 to 10-6 mol/l) caused significant, endothelium-independent vasorelaxation, which was inhibited by the EP4 receptor blocker BGC201531. In contrast, higher concentrations of PGE2 evoked significant EP1-dependent vasoconstriction, which could not be reversed by the EP4 receptor agonist CAY10598. We also confirmed previous observations that PGE2 primarily evokes constriction in intracerebral arterioles isolated from R. norvegicus. Importantly, vascular mRNA and protein expression of vasodilator EP4 receptors was significantly higher than that of vasoconstrictor EP1 receptors in human cerebral arterioles. PGE2 at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles. This bimodal vasomotor response is consistent with both the proposed vasodilator role of PGE2 during functional hyperemia and its putative role in cerebral vasospasm associated with subarachnoid hemorrhage in human patients