Si XII X-Ray Satellite Lines in Solar Flare Spectra

The temperature dependence of the Si XII n = 3 and 4 dielectronic satellite line features at 5.82 and 5.56 A, respectively, near the Si XIII 1s2-1s3p and 1s2-1s4p lines (5.681 and 5.405 A), is calculated using atomic data presented here. The resulting theoretical spectra are compared with solar flare spectra observed by the RESIK spectrometer on the CORONAS-F spacecraft. The satellites, like the more familiar n = 2 satellites near the Si XIII 1s2-1s2p lines, are formed mostly by dielectronic recombination, but unlike the n = 2 satellites, are unblended. The implications for similar satellite lines in flare Fe spectra are discussed

Solar Flare Abundances of Potassium, Argon, and Sulphur

The absolute coronal abundances of potassium has been determined for the first time from X-ray solar flare line and continuous spectra together with absolute and relative abundances of Ar and S. Potassium is of importance in the continuing debate concerning the nature of the coronal/photospheric element abundance ratios which are widely considered to depend on first ionization potential since it has the lowest FIP of any common element in the Sun. The measurements were obtained with the RESIK crystal spectrometer on the Coronas-F spacecraft. A differential emission measure DEM = const. x exp (-(beta)T(sub e) was found to be the most consistent with the data out of three models considered. We find that the coronal ratio [K/H] = 3.7 x 10(exp - 7), a factor 3 times photospheric, in agreement with other observations using line-to-line ratios. Our measured value for the coronal ratio [Ar/H] = 1.5 x 10(exp -6) is significantly less than photospheric, indicating that there is a slight depletion of this high-FIP element in the corona. For S (an intermediate-FIP element) we obtained [S/H] = 2.2 x 10(exp - 5), approximately the same as in previous work

Varying Calcium Abundances in Solar Flares seen by Solar Maximum Mission

We report on calcium abundance $A({\rm Ca})$ estimates during the decay phases of 194 solar X-ray flares using archived data from the Bent Crystal Spectrometer (BCS) on Solar Maximum Mission (operational 1980~--~1989). The abundances are derived from the ratio of the total calcium X-ray line emission in BCS channel~1 to that in neighboring continuum, with temperature from a satellite-to-resonance line ratio. Generally the calcium abundance is found to be about three times the photospheric abundance, as previously found, indicating a ``FIP'' (first ionization potential) effect for calcium which has a relatively low FIP value. The precision of the abundance estimates (referred to hydrogen on a logarithmic scale with $A({\rm H}) = 12$), is typically $\sim \pm 0.01$, enabling any time variations of $A({\rm Ca})$ during the flare decay to be examined. For a total of 270 short time segments with $A({\rm Ca})$ determined to better than 2.3\% accuracy, many (106; 39\%) showed variations in $A({\rm Ca})$ at the $3\sigma$ level. For the majority, 74 (70\%) of these 106 segments $A({\rm Ca})$ decreased with time, and for 32 (30\%) $A({\rm Ca})$ increased with time. For 79 out of 270 (29\%) we observed constant or nearly constant $A({\rm Ca})$, and the remaining 85 (31\%) with irregular time behavior. A common feature was the presence of discontinuities in the time behavior of $A({\rm Ca})$. Relating these results to the ponderomotive force theory of Laming, we attribute the nature of varying $A({\rm Ca})$ to the emergence of loop structures in addition to the initial main loop, each with its characteristic calcium abundance.Comment: Astrophysical Journal (to be published). 14 pages with 8 figure

Znaczenie modyfikacji epigenetycznych w patogenezie białaczek

Relations between genetic alterations and different types of leukemia lead to understanding that leukemogenesis is a mainly genetic-based phenomenon. However recently role of factors of epigenetic nature is highlighted in research on oncogenic transformation. Epigenetic regulation is defined as heritable patterns that are not related to DNA sequence. There are three major forms of epigenetic regulation: DNA methylation, histone modifications – methylation and acetylation – and regulation through small non-coding RNAs. Epigenetic regulation is important in development of different types of leukemia. Changes in DNA methylation patterns as well as in histone methylation and acetylation were detected in samples from patients with leukemia. In addition different profiles of miRNA, one subtype of noncoding RNAs, were associated with this disease. What is more, alteration in activity of enzymes involved in regulation of DNA and histone modification can also be detected in leukemic cells. Current knowledge of epigenetic regulation allows for better diagnostic of leukemia and better understanding of mechanism involved in its therapy. It also allowed for development of new forms of therapies targeted specifically on mechanisms involved in epigenetic regulation

Interakcje pomiędzy BCR/ABL a RNAi

Chronic myeloid leukemia (CML) is a malignant disease of progenitor myeloid cells caused by chromosomal translocation that results in the forming of diminutive Philadephia chromosome that harbors BCR/ABL fusion oncogene. The product of this oncogene, a tyrosine kinase, alters several important regulatory pathways related to cell growth and differentiation thus leading to cancer transformation. Major form of CML therapy is based on tyrosine kinase inhibitors, first of all imatinib (IM). Some patients develop resistance to IM in the course of treatment. In the process of leukemogenesis the activity of miRNAs – one of groups of RNAs involved in RNA interference (RNAi) – is altered. Signatures of altered miRNAs activity may serve as a prognostic factor in the development and therapy of several diseases. Moreover, other group of RNAs involved in RNAi – siRNA – might be valuable addition to array of specific therapeutics targeted the BCR/ABL kinase

Non-Equilibrium Processes in the Solar Corona, Transition Region, Flares, and Solar Wind \textit{(Invited Review)}

We review the presence and signatures of the non-equilibrium processes, both non-Maxwellian distributions and non-equilibrium ionization, in the solar transition region, corona, solar wind, and flares. Basic properties of the non-Maxwellian distributions are described together with their influence on the heat flux as well as on the rates of individual collisional processes and the resulting optically thin synthetic spectra. Constraints on the presence of high-energy electrons from observations are reviewed, including positive detection of non-Maxwellian distributions in the solar corona, transition region, flares, and wind. Occurrence of non-equilibrium ionization is reviewed as well, especially in connection to hydrodynamic and generalized collisional-radiative modelling. Predicted spectroscopic signatures of non-equilibrium ionization depending on the assumed plasma conditions are summarized. Finally, we discuss the future remote-sensing instrumentation that can be used for detection of these non-equilibrium phenomena in various spectral ranges.Comment: Solar Physics, accepte

Mass-Spring System (MSS) 3D simulation of a thin flexible membrane with a new model of the elasticity parameters

Mass Spring Systems (MSS) are often used to simulate the behavior of deformable objects, for example in computer graphics (modeling clothes for virtual characters) or in medicine (surgical simulators that facilitate the planning of surgical operations) due to their simplicity and speed of calculation. This paper presents a new, two-parameter method (TP MSS) of determining the values of spring coefficients for this model. This approach can be distinguished by a constant parameter which is calculated once at the beginning of the simulation, and a variable parameter that must be updated at each simulation step. The value of this variable parameter depends on the shape changes of the elements forming the mesh of the simulated object. The considered mesh is built of elements in the shape of acute-angled triangles. The results obtained using the new model were compared to FEM simulations and the Van Gelder model. The simulation results for the new model were also compared with the results of the bubble inflation test

Polymorphism of the flap endonuclease 1 gene in keratoconus and Fuchs endothelial corneal dystrophy

Oxidative stress is implicated in the pathogenesis of many diseases, including serious ocular diseases, keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD). Flap endonuclease 1 (FEN1) plays an important role in the repair of oxidative DNA damage in the base excision repair pathway. We determined the association between two single nucleotide polymorphisms (SNPs), c.-441G>A (rs174538) and g.61564299G>T (rs4246215), in the FEN1 gene and the occurrence of KC and FECD. This study involved 279 patients with KC, 225 patients with FECD and 322 control individuals. Polymerase chain reaction (PCR) and length polymorphism restriction fragment analysis (RFLP) were applied. The T/T genotype of the g.61564299G>T polymorphism was associated with an increased occurrence of KC and FECD. There was no association between the c.-441G>A polymorphism and either disease. However, the GG haplotype of both polymorphisms was observed more frequently and the GT haplotype less frequently in the KC group than the control. The AG haplotype was associated with increased FECD occurrence. Our findings suggest that the g.61564299G>T and c.-441G>A polymorphisms in the FEN1 gene may modulate the risk of keratoconus and Fuchs endothelial corneal dystrophy.peer-reviewe