FORMULATION AND EVALUATION OF RABEPRAZOLE SODIUM AND DOMPERIDONE PELLETS

The aim of present study was to formulate and evaluate Rabeprazole sodium and Domperidone pellets for the treatment of gastro esophageal reflux disease. Modified release drug delivery systems were capable of drug release when and where it requires. In the present study delayed release Rabeprazole sodium pellets were prepared by a drug layering, seal coating and enteric coating by using eudragit L100 55 as enteric coating material different weight gains were developed and evaluated for optimized formula and Sustained release Domperidone pellets were prepared by drug layering, sustained release coating with ethyl cellulose 7 cps as sustained release material. The formulated coated pellets were evaluated for angle repose, bulk density, tapped density, hausener ratio, Carr’s index, FTIR, DSC. Moisture content. In vitro release and acid-resistance studies were carried out in simulated gastric fluid and simulated intestinal fluid, respectively. The results indicated that Rabeprazole sodium pellets with seal coat of 10 % (F13) formula and 30% of enteric coat with eudragit L 100 55 (F30) formula showed good acid resistance and drug release. Domperidone pellets with 10 % (F9) and 12 % (F10) formulas of extended release coating with ethyl cellulose were showed required sustained action. The optimized formulations were evaluated for different release kinetics and found that Rabeprazole delayed release pellets were following First order and Korsemeyer-peppas equation Hence the release mechanism was by concentration dependent dissolution process. Domperidone pellets were following First order and Higuchi’s equation Hence the release mechanism was by concentration dependent diffusion process. F20 formula of rabeprazole pellets and F10 of formula domperidone pellets were showed required release characteristics were selected and filled in to the capsules

Factors influencing the livelihood index and level of aspiration of fisherwomen

A study was conducted among fifty women fish vendors in Kancheepuram and Chennai districts to determine the factors influencing the livelihood index and leve! of aspiration. The independent variables such as annual income, scientific orientation, expenditure per year and savings per year were found to have highest factor loadings on livelihood index and level of aspiration of fisherwomen. Besides most of the fisherwomen had a high level (score of < 50) of livelihood index and a high level (score greater than 13) of aspiratio

Preparing fisher folk for Climate Change: Communication Strategies

Climate change has become a worldwide concern, increasingly impacting the livelihoods of individuals in both the global north and south. The need to develop effective adaptation and mitigation strategies in the south has become crucial to securing livelihoods and community development. A critical element in promoting effective and successful adaptation and mitigation strategies is communication. Originally presented as a complex and abstract scientific problem, climate change information is now shared and discussed among various disciplines and stakeholders. Effective communication among stakeholders can help to identify problems, raise awareness, encourage dialogue, and influence behavioural change (Johnson 2011; Moser 2010; Nerlich, Koteyko& Brown 2010). However, in order to communicate climate change effectively, it is important to understand and acknowledge how individuals and communities think about, interpret, and discuss the causes, issues, and possible adaptation and mitigation actions (Africa Talks Climate, BBC World Service Trust 2010)

Discriminant Analysis: A method for determining Relative importance of predictor variables

Discriminant Analysis: A method for determining Relative importance of predictor variable

Gender issues in Marine Fisheries

The overall G.D.E.I of 63.03 suggests that there is further potential for effective continued use of this model in similar locations in Coastal Karnataka, since the diffusion of this technology to other end users in this region, is in the initial stage of the adoption curve with the innovators dominating the mussel groups. Women mussel farmers in the group need to be strengthened and their potential has to be harnessed on the group dimensions such as influence, styles of influence, decision making, task function ,feelings, norms, interpersonal trust and group achievements

Factor analysis: a technique for data reduction

Factor analysis: a technique for data reductio

Livelihood and level of aspiration of coastal fisherfolk of Tamilnadu

A study on the livelihood status of different stakeholder categories in marine fisheries sector was undertaken. Four categories of stake holders namely fishermell operating motorized craft, fishermen operating mechanized craft, fishermen operating motorized craft + boat building and fisherwomen who were fish vendors were selected for the study

Traditional Fish Traps and Indigenous Fishing Devices of North Malabar Region of Kerala

The present study was carried out to document the various kinds of indigenous traps and fishing gears used in 20 river systems covering three districts of North Malabar region of Kerala. The use of indigenous traps such as box traps namely “Chemballi Koodu”, and other fishing gears and methods such as Komma, Njandu Kothhi, Challam and Chemeen Kori, their dimensions, fabrication and methods of operation are discussed in this study

Inter-Sectoral Mobility: The Case of Migrant Labourers in the Secondary Sector of Marine Fisheries of Karnataka

The marine fisheries sector represents a transition from a subsistence economy to a highly industrialized one. The employment potential of the secondary and tertiary sectors in marine fisheries has increased tremendously in the present scenario of globalization and liberalization. The present paper documents the case of migrant labourers from Tamilnadu who have been forced to migrate from an agrarian economy in to fisheries based economy in coastal Karnataka in order to support their livelihood, due to frequent droughts, crop failure and reduced wages faced by them as agricultural labourers in their native state. The study conducted in Mangalore fisheries harbour in the Dakshina Kannada district of Karnataka documents the socio-economic profile of the migrants, the peak, medium and lean seasons of fishing, the differential wage patterns among the men and women labourers, and the factors which discriminated the high and low levels of aspiration among the migrants. The Discriminant function analysis revealed that, variables namely age, education, family type and annual income had shown positive influence in differentiating the high from low levels of aspiration among migrant labourers. The results of theWilcoxon-Mann-Whitney test showed that significant differences were found in between high and low levels of aspiration with respect to variables such as education status of the respondents, occupational experience and the level of awareness of developmental programmes