2,114 research outputs found

    Potential one-forms for hyperk\"ahler structures with torsion

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    It is shown that an HKT-space with closed parallel potential 1-form has D(2,1;−1)D(2,1;-1)-symmetry. Every locally conformally hyperk\"ahler manifold generates this type of geometry. The HKT-spaces with closed parallel potential 1-form arising in this way are characterized by their symmetries and an inhomogeneous cubic condition on their torsion.Comment: 16 pages, Latex, no figure

    Comportamento de genĂłtipos de canola em MaringĂĄ em 2003.

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    A novel mouse model of Campylobacter jejuni enteropathy and diarrhea

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    Campylobacter infections are among the leading bacterial causes of diarrhea and of ‘environmental enteropathy’ (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter has been a major limitation for understanding its pathogenesis, interventions or vaccine development. We describe a robust standard mouse model that can exhibit reproducible bloody diarrhea or growth failure, depending on the zinc or protein deficient diet and on antibiotic alteration of normal microbiota prior to infection. Zinc deficiency and the use of antibiotics create a niche for Campylobacter infection to establish by narrowing the metabolic flexibility of these mice for pathogen clearance and by promoting intestinal and systemic inflammation. Several biomarkers and intestinal pathology in this model also mimic those seen in human disease. This model provides a novel tool to test specific hypotheses regarding disease pathogenesis as well as vaccine development that is currently in progress

    Impact of previous hepatitis B infection on the clinical outcomes from chronic hepatitis C? A population-level analysis

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    Chronic coinfection with hepatitis C virus (HCV) and hepatitis B virus (HBV) is associated with adverse liver outcomes. The clinical impact of previous HBV infection on liver disease in HCV infection is unknown. We aimed at determining any association of previous HBV infection with liver outcomes using antibodies to the hepatitis B core antigen (HBcAb) positivity as a marker of exposure. The Scottish Hepatitis C Clinical Database containing data for all patients attending HCV clinics in participating health boards was linked to the HBV diagnostic registry and mortality data from Information Services Division, Scotland. Survival analyses with competing risks were constructed for time from the first appointment to decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver‐related mortality. Records of 8513 chronic HCV patients were included in the analyses (87 HBcAb positive and HBV surface antigen [HBsAg] positive, 1577 HBcAb positive and HBsAg negative, and 6849 HBcAb negative). Multivariate cause‐specific proportional hazards models showed previous HBV infection (HBcAb positive and HBsAg negative) significantly increased the risks of decompensated cirrhosis (hazard ratio [HR]: 1.29, 95% CI: 1.01‐1.65) and HCC (HR: 1.64, 95% CI: 1.09‐2.49), but not liver‐related death (HR: 1.02, 95% CI: 0.80‐1.30). This is the largest study to date showing an association between previous HBV infection and certain adverse liver outcomes in HCV infection. Our analyses add significantly to evidence which suggests that HBV infection adversely affects liver health despite apparent clearance. This has important implications for HBV vaccination policy and indications for prioritization of HCV therapy

    The determination of HNO3 column amounts from tunable diode laser heterodyne spectrometer spectra taken at Jungfruajoch, Switzerland

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    In May of 1991 a tunable diode laser heterodyne spectrometer built by the National Physical Laboratory was operated at the International Scientific Station of the Jungfraujoch (46.5 deg N, 8.0 deg E, altitude 3.56 km). Nitric acid spectra in the region of 868 wavenumbers were recorded at sunset and sunrise on two separate days at a resolution of 0.0013 wavenumbers with a signal-to-noise ratio of approximately 130:1. A vertical column amount of HNO3 of 1.61 x 10(exp 16) molecules/sq cm was determined using an atmospheric transmission model developed at the University of Denver. The mean of a number of mid-latitude, northern hemisphere profiles was used as the initial profile for the inversion. A comparison of different initial profiles provides information on the sensitivity of the retrieved column amount of 1.61 x 10(exp 16) molecules/sq cm lies within the range of values published in the World Meteorological Organization Report no. 16 (1986), but is considerably larger than the value of (0.99 - 1.29) x 10(exp 16) reported by Rinsland et al. (1991) for June during the period 1986 to 1990

    The limits of social class in explaining ethnic gaps in educational attainment

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    This paper reports an analysis of the educational attainment and progress between age 11 and age 14 of over 14,500 students from the nationally representative Longitudinal Study of Young People in England (LSYPE). The mean attainment gap in national tests at age 14 between White British and several ethnic minority groups were large, more than three times the size of the gender gap, but at the same time only about one-third of the size of the social class gap. Socio-economic variables could account for the attainment gaps for Black African, Pakistani and Bangladeshi students, but not for Black Caribbean students. Further controls for parental and student attitudes, expectations and behaviours indicated minority ethnic groups were on average more advantaged on these measures than White British students, but this was not reflected proportionately in their levels of attainment. Black Caribbean students were distinctive as the only group making less progress than White British students between age 11 and 14 and this could not be accounted for by any of the measured contextual variables. Possible explanations for the White British-Black Caribbean gap are considered

    Constraints on the Electrical Charge Asymmetry of the Universe

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    We use the isotropy of the Cosmic Microwave Background to place stringent constraints on a possible electrical charge asymmetry of the universe. We find the excess charge per baryon to be qe−p<10−26eq_{e-p}<10^{-26}e in the case of a uniform distribution of charge, where ee is the charge of the electron. If the charge asymmetry is inhomogeneous, the constraints will depend on the spectral index, nn, of the induced magnetic field and range from qe−p<5×10−20eq_{e-p}<5\times 10^{-20}e (n=−2n=-2) to qe−p<2×10−26eq_{e-p}<2\times 10^{-26}e (n≄2n\geq 2). If one could further assume that the charge asymmetries of individual particle species are not anti-correlated so as to cancel, this would imply, for photons, qÎł<10−35eq_\gamma< 10^{-35}e; for neutrinos, qÎœ<4×10−35eq_\nu<4\times10^{-35}e; and for heavy (light) dark matter particles qdm<4×10−24eq_{\rm dm}<4\times10^{-24}e (qdm<4×10−30eq_{\rm dm}<4\times10^{-30}e).Comment: New version to appear in JCA

    Origin of Magnetic Fields in the Universe Due to Nonminimal Gravitational-Electromagnetic Coupling

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    Basically the only existing theories for the creation of a magnetic field B in the Universe are the creation of a seed field of order 10^{-20} G in spiral galaxy which is subsequently supposedly amplified up to the observed 10^{-6} - 10^{-5} G by a dynamo process or a seed intergalactic field of magnitude 10^{-12} - 10^{-10} G which is amplified by collapse and differential rotation. No satisfactory dynamo theory, however, exists today. We show that a 10^{-6} - 10^{-5} G magnetic field in spiral galaxies is directly obtained from a nonminimal gravitational-electromagnetic coupling, without the need of significant dynamo amplification.Comment: 5 pages, Latex (Revtex), no figures, To appear in PR
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