A Modified Architecture for Radix-4 Booth Multiplier with Adaptive Hold Logic

High speed digital multipliers are most efficiently used in many applications such as Fourier transform, discrete cosine transforms, and digital filtering. The throughput of the multipliers is based on speed of the multiplier, and then the entire performance of the circuit depends on it. The pMOS transistor in negative bias cause negative bias temperature instability (NBTI), which increases the threshold voltage of the transistor and reduces the multiplier speed. Similarly, the nMOS transistor in positive bias cause positive bias temperature instability (PBTI).These effects reduce the transistor speed and the system may fail due to timing violations. So here a new multiplier was designed with novel adaptive hold logic (AHL) using Radix-4 Modified Booth Multiplier. By using Radix-4 Modified Booth Encoding (MBE), we can reduce the number of partial products by half. Modified booth multiplier helps to provide higher throughput with low power consumption. This can adjust the AHL circuit to reduce the performance degradation. The expected result will be reduce threshold voltage, increase throughput and speed and also reduce power. This modified multiplier design is coded by Verilog and simulated using Xilinx ISE 12.1 and implemented in Spartan 3E FPGA kit

Cardiac Phase Retrieval in Intravascular Ultrasound Sequences

Acquisition of intravascular ultrasound (IVUS) sequences is a major artifact for 3-D exploring of coronary arteries. Most current techniques are based on the electrocardiogram (ECG) signal to obtain a gated pullback without longitudinal motion by using specific hardware or the ECG signal itself. We present an image-based approach for cardiac phase retrieval from coronary IVUS sequences without an ECG signal. A signal reflecting cardiac motion is computed by exploring the image intensity local mean evolution. The signal is filtered by a series of filters namely Gaussian and Optical at the main cardiac frequency. After applying minimum and maximum values of threshold, based on the pixel values at different position, the cardiac phase is retrieved and the report is mailed to the concerned. DOI: 10.17762/ijritcc2321-8169.15039

Cutaneous mastocytosis. Getting beneath the skin of the issue: a case report

An eleven month old girl presented with chronic urticaria since three months of age. There was a generalised hyperpigmented maculo-papular rash. Darier sign was positive. The skin biopsy showed plenty of spindle shaped mast cells with eosinophilic cytoplasm infiltrating the dermis and the appendiceal structures. The diagnosis of cutaneous mastocytosis (urticaria pigmentosa) was made. The child received symptomatic relief with chronic oral hydroxyzine and ranitidine therapy. Automated epinephrine self-injectors usually prescribed in this condition for self-management of anaphylactic episodes were not available. Intramuscular administration of (1:1000) diluted adrenaline via a disposable tuberculin syringe was taught to the mother. A medical bracelet containing her diagnosis and instructions in emergency was custom-made for her

STRUCTURING REVERSIBLE CIRCUIT TO OVERCOME LOW-POWER DISSIPATION

This paper presents a design methodology for that realization of Booth’s multiplier in reversible mode. Booth’s multiplier is recognized as among the fastest multipliers in literature so we have proven a competent design methodology in reversible paradigm. Reversible logic attains the attraction of researchers within the last decade mainly because of low-power dissipation. Designers’ endeavors therefore are ongoing in creating complete reversible circuits composed of reversible gates. All of the theorems provide lower bounds for quantity of gates, garbage outputs, circuit delay and quantum cost. The important thing achievement from the design is, it is capable of doing dealing with both signed and unsigned figures, which isn't contained in the present circuits considered within this paper. We assess the 4×4 form of the suggested Booth’s multiplier using the two existing designs. Theoretical underpinnings, established for that suggested design, reveal that the suggested circuit is extremely efficient from reversible circuit design perspective. The suggested architecture is capable of doing performing both signed and unsigned multiplication of two operands without getting any feedbacks, whereas existing multipliers in reversible mode consider loop that is strictly disallowed reversible logic design

Isolation of Phytochemical and Evaluation of Antiasthmatic Potency of Ficus racemosa

The Present study reports important secondary metabolites present in Ficus racemosa The Ficus racemosa belong to the family Moraceae, it is popularly known as Glomerata, Cluster fig tree as well as ‘Udumbara’ in Marathi. Various plant parts such as bark, root, leaf, fruits are used as astringent, carminative, anti-dysentery, diabetes, leucoderma, antiasthmatic, hepatoprotective, antioxidant. The powdered Bark was subjected for extraction by using ethanol. These extract were evaluated for detection of various secondary metabolites, like Steroids, Glycosides, tannins, Terpenoids, Alkaloids, Flavonoids. This work evaluated the stem bark of this plant for its Phytochemical and Antiasthmatic activity. Keywords: Ficus racemosa, Steroids, Antiasthmatic, Moracea

Serum acid phosphatase level - is it a marker for diagnosis of malaria

Background: Malaria is endemic throughout most of the tropics. Technically, detection of malaria parasite may be missed due to low parasite density at sampling time and poor blood film preparation. The study was aimed to evaluate the serum acid phosphatase levels as a possible diagnostic marker for malarial infections.Methods: This study was conducted on a total of 100 subjects (40 malaria cases, 30 non-malarial cases and 30 sex and age matched healthy controls attending the department of medicine, PESIMSR, Kuppam. Venous blood sample was collected and serum acid phosphatase (ACP) level estimation was be done by enzymatic method using commercial kit (Raichem diagnostics kit).Results: Serum ACP level was highly significantly elevated in malarial group (Mean±SD) (3.14±1.22) when compared with control (1.33±0.72) and non-malarial (1.81±0.30) groups (P value <0.001.).Conclusions: In this study, there was a significant increase in the serum ACP levels in malarial patients as compared to other groups. This suggests that serum ACP levels can be used as a marker for malaria.

The impact of COVID-19 lockdown measures on the Indian summer monsoon

Aerosol concentrations over Asia play a key role in modulating the Indian summer monsoon (ISM) rainfall. Lockdown measures imposed to prevent the spread of the COVID-19 pandemic led to substantial reductions in observed Asian aerosol loadings. Here, we use bottom-up estimates of anthropogenic emissions based on national mobility data from Google and Apple, along with simulations from the ECHAM6-HAMMOZ state-of-the-art aerosol-chemistry-climate model to investigate the impact of the reduced aerosol and gases pollution loadings on the ISM. We show that the decrease in anthropogenic emissions led to a 4 W m−2 increase in surface solar radiation over parts of South Asia, which resulted in a strengthening of the ISM. Simultaneously, while natural emission parameterizations are kept the same in all our simulations, the anthropogenic emission reduction led to changes in the atmospheric circulation, causing accumulation of dust over the Tibetan plateau (TP) during the pre-monsoon and monsoon seasons. This accumulated dust has intensified the warm core over the TP that reinforced the intensification of the Hadley circulation. The associated cross-equatorial moisture influx over the Indian landmass led to an enhanced amount of rainfall by 4% (0.2 mm d−1) over the Indian landmass and 5%–15% (0.8–3 mm d−1) over central India. These estimates may vary under the influence of large-scale coupled atmosphere–ocean oscillations (e.g. El Nino Southern Oscillation, Indian Ocean Dipole). Our study indicates that the reduced anthropogenic emissions caused by the unprecedented COVID-19 restrictions had a favourable effect on the hydrological cycle over South Asia, which has been facing water scarcity during the past decades. This emphasizes the need for stringent measures to limit future anthropogenic emissions in South Asia for protecting one of the world's most densely populated regions

Determination, Development and Validation of Method for Simultaneous AXITINIB Pharmaceutical Dosage form by a Reverse Phase HPLC

A simple and selective LC method is described for the determination of AXITINIB dosage forms. Chromatographic separation is observed on a c18 packing column using mobile phase with a mixture of TEA -Acetonitrile (50:50) with detected at 254nm. Linearity was observed in the range 15-45 µg /ml for AXITINIB (r2 =0.997) for drug estimated by the proposed methods was in good agreement with the label claim. The proposed method was validated. The accuracy of the methods was assessed by recovery studies at three different levels. The current study indicated the absence of interference of commonly encountered pharmaceutical additives. The method was precise to be indicated by the repeatability analysis, by showing %RSD > 2. All statistical data proved the validity of the methods and used for routine analysis of pharmaceutical dosage form