Adolescent vegetable consumption: the role of socioemotional family characteristics

Objective: To describe associations between adolescents’ frequency of vegetable consumption, food parenting practices and socioemotional family characteristics, and to explore potential mediated relationships that may contribute to an understanding of the family processes involved. Design: Cross-sectional survey among adolescents aged 13–15 years. Setting: A survey questionnaire including self-report measures on adolescents’ frequency of vegetable consumption, perceived food parenting practices (i.e. family dinner frequency, maternal/paternal healthy eating guidance (HEG), maternal/paternal social support for vegetable consumption) and socioemotional family characteristics (i.e. general family functioning and level of cohesion and conflict within the family) was distributed in a convenience sample of secondary school students. Participants: Four hundred forty students from five secondary schools in eastern Norway completed the questionnaire. Results: Results from multiple linear regression analysis revealed positive and statistically significant associations between adolescents’ frequency of vegetable consumption, maternal HEG and family cohesion. A partial indirect (mediated) association between family cohesion and adolescents’ frequency of vegetable consumption, working through maternal HEG, was also found. Conclusions: Results from the present study suggest that perceived family cohesion may influence adolescents’ frequency of vegetable consumption both directly and indirectly. However, there is a need for continued investigation of family-related factors influencing adolescent eating. In particular, the role of socioemotional family characteristics should be further scrutinised in future studies.acceptedVersio

Oldest Ice in Antarctica – the 3d continental ice sheet modelling perspective.

The ongoing quest to find the oldest continuous ice core in Antarctica draws on the expertise of multiple disciplines. Here we present our efforts to inform on the location of potential future drilling sites by 3d continental ice sheet modelling. We present the results of an ensemble of ice sheet model simulations spanning the last 2 million years utilizing a variety of different model setups and boundary conditions including new radar derived bedrock elevation. In our analysis we focus on the physical properties and ice dynamics around the major drill sites such as Dome Fuji and Dome C and discuss the effects of the ice sheets history on the present day flow regime. By using a continental setup and applying a transient forcing created from paleo climate modelling studies and ice core data we are able to take a holistic view of Antarctic Ice Sheet dynamics and its impact on the vertical stratigraphy around the East Antarctic ice domes

Gastric Emptying Time and Volume of the Small Intestine as Objective Markers in Patients With Symptoms of Diabetic Enteropathy

BACKGROUND/AIMS: Patients with diabetes mellitus (DM) often suffer from gastrointestinal (GI) symptoms, but these correlate poorly to established objective GI motility measures. Our aim is to perform a detailed evaluation of potential measures of gastric and small intestinal motility in patients with DM type 1 and severe GI symptoms. METHODS: Twenty patients with DM and 20 healthy controls (HCs) were included. GI motility was examined with a 3-dimensional-Transit capsule, while organ volumes were determined by CT scans. RESULTS: Patients with DM and HCs did not differ with regard to median gastric contraction frequency (DM 3.0 contractions/minute [interquartile range {IQR}, 2.9-3.0]; HCs 2.9 [IQR, 2.8-3.1]; P = 0.725), amplitude of gastric contractions (DM 9 mm [IQR, 8-11]; HCs 11 mm (IQR, 9-12); P = 0.151) or fasting volume of the stomach wall (DM 149 cm3 [IQR, 112-187]; HCs 132 cm3 [IQR, 107-154]; P = 0.121). Median gastric emptying time was prolonged in patients (DM 3.3 hours [IQR, 2.6-4.6]; HCs 2.4 hours [IQR, 1.8-2.7]; P = 0.002). No difference was found in small intestinal transit time (DM 5 hours [IQR, 3.7-5.6]; HCs 4.8 hours [IQR, 3.9-6.0]; P = 0.883). However, patients with DM had significantly larger volume of the small intestinal wall (DM 623 cm3 [IQR, 487-766]; HCs 478 cm3 [IQR, 393-589]; P = 0.003). Among patients, 13 (68%) had small intestinal wall volume and 9 (50%) had gastric emptying time above the upper 95% percentile of HCs. CONCLUSION: In our study, gastric emptying time and volume of the small intestinal wall appeared to be the best objective measures in patients with DM type 1 and symptoms and gastroenteropathy

Promising Oldest Ice sites in East Antarctica based on thermodynamical modelling

To resolve the mechanisms behind the major climate reorganisation, which occurred between 0.9 and 1.2 Ma, the recovery of a suitable 1.5 million-year-old ice core is fundamental. The quest for an Oldest Ice core requires a number of key boundary conditions, of which the poorly known basal geothermal heat flux (GHF) is lacking. We use a transient thermodynamical 1-D vertical model that solves for the rate of change of temperature in the vertical, with surface temperature and modelled GHF as boundary conditions. For each point on the ice sheet, the model is forced with variations in atmospheric conditions over the last 2 Ma and modelled ice-thickness variations. The process is repeated for a range of GHF values to determine the value of GHF that marks the limit between frozen and melting conditions over the whole ice sheet, taking into account 2 Ma of climate history. These threshold values of GHF are statistically compared to existing GHF data sets. The new probabilistic GHF fields obtained for the ice sheet thus provide the missing boundary conditions in the search for Oldest Ice. High spatial resolution radar data are examined locally in the Dome Fuji and Dome C regions, as these represent the ice core community's primary drilling sites. GHF, bedrock variability, ice thickness and other essential criteria combined highlight a dozen major potential Oldest Ice sites in the vicinity of Dome Fuji and Dome C, where GHF could allow for Oldest Ice

Modelling the Antarctic Ice Sheet across the mid-Pleistocene transition – implications for Oldest Ice

The international endeavour to retrieve a continuous ice core, which spans the middle Pleistocene climate transition ca. 1.2–0.9 Myr ago, encompasses a multitude of field and model-based pre-site surveys. We expand on the current efforts to locate a suitable drilling site for the oldest Antarctic ice core by means of 3-D continental ice-sheet modelling. To this end, we present an ensemble of ice-sheet simulations spanning the last 2 Myr, employing transient boundary conditions derived from climate modelling and climate proxy records. We discuss the imprint of changing climate conditions, sea level and geothermal heat flux on the ice thickness, and basal conditions around previously identified sites with continuous records of old ice. Our modelling results show a range of configurational ice-sheet changes across the middle Pleistocene transition, suggesting a potential shift of the West Antarctic Ice Sheet to a marine-based configuration. Despite the middle Pleistocene climate reorganisation and associated ice-dynamic changes, we identify several regions conducive to conditions maintaining 1.5 Myr (million years) old ice, particularly around Dome Fuji, Dome C and Ridge B, which is in agreement with previous studies. This finding strengthens the notion that continuous records with such old ice do exist in previously identified regions, while we are also providing a dynamic continental ice-sheet context

Cardiovascular and renal outcomes with empagliflozin in heart failure

BACKGROUND Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure in patients regardless of the presence or absence of diabetes. More evidence is needed regarding the effects of these drugs in patients across the broad spectrum of heart failure, including those with a markedly reduced ejection fraction. METHODS In this double-blind trial, we randomly assigned 3730 patients with class II, III, or IV heart failure and an ejection fraction of 40% or less to receive empagliflozin (10 mg once daily) or placebo, in addition to recommended therapy. The primary outcome was a composite of cardiovascular death or hospitalization for worsening heart failure. RESULTS During a median of 16 months, a primary outcome event occurred in 361 of 1863 patients (19.4%) in the empagliflozin group and in 462 of 1867 patients (24.7%) in the placebo group (hazard ratio for cardiovascular death or hospitalization for heart failure, 0.75; 95% confidence interval [CI], 0.65 to 0.86; P<0.001). The effect of empagliflozin on the primary outcome was consistent in patients regardless of the presence or absence of diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.70; 95% CI, 0.58 to 0.85; P<0.001). The annual rate of decline in the estimated glomerular filtration rate was slower in the empagliflozin group than in the placebo group (-0.55 vs. -2.28 ml per minute per 1.73 m2 of body-surface area per year, P<0.001), and empagliflozin-treated patients had a lower risk of serious renal outcomes. Uncomplicated genital tract infection was reported more frequently with empagliflozin. CONCLUSIONS Among patients receiving recommended therapy for heart failure, those in the empagliflozin group had a lower risk of cardiovascular death or hospitalization for heart failure than those in the placebo group, regardless of the presence or absence of diabetes