FORMULATION AND EVALUATION OF HYDROGEL WITH ASCORBIC ACID USING ALOE VERA GEL POWDER AS A DRUG CARRIER

ABSTRACTObjective: The aim of this study is to develop a controlled release hydrogel and to evaluate the efficiency of its drug delivery. Even though the synthetic polymer drug carriers will be safely metabolized, they will not impart any health benefit unlike the natural carriers such as starch and Aloe vera. Hence, in the present investigation in vitro release characteristics of ascorbic acid based hydrogel formulated using Aloe vera gel powder as a drug carrier and nutrient fortifying excipient has been used.Methods: Hydrogel is a recent approach of sustained drug delivery which is advantageous because of its unique drug release patterns like swelling and diffusion. Vitamin C is a well known antioxidant which scavenges free radicals and Aloe vera enhances the bioavailability of vitamin C which is also protecting it from degradation along with its other essential properties.Results: Various evaluation parameters have been carried out such as swelling studies and in vitro release studies. These evaluation studies results have shown that maximum swelling percentage was seen at pH 1.4 and least in distilled water which imparts that even in acidic medium the formulated hydrogel can outlive. Appreciable swelling was seen in pH 5.4 and 7.4. Furthermore, the hydrogel was seen to undergo disintegration in distilled water.Conclusion: The in vitro release studies showed that the drug was released at a pre-determined rate over a controlled period of time hence it can be used in sustained drug delivery. The materials used in this study are bio available and biocompatible hence will not impart any toxicity and side-effects

ALOE VERA POWDER BASED MATRIX TABLET FOR ORAL CONTROLLED DELIVERY OF HIGHLY SOLUBLE DRUG

This study mainly aimed for oral control delivery system of highly water soluble drug using aloe vera powder as a carrier for matrix tablet. Ascorbic acid is taken as a model drug for its high solubility. Different concentrations such as 30 %, 40 % and 50 % of matrix tablets of Aloe Vera powder are made by wet granulation technique using starch paste as a binder. The formulated granules were further subjected to Quality control test such as Angle of repose (º), Bulk Density, Carr's Index and Hausner ratio. These matrix tablets are then subjected to in vitro drug release using USP dissolution apparatus. The amount of ascorbic acid released from the matrix is estimated by using UV spectrometer and this result is compared with marketed ascorbic acid tablets. Formulation containing 40 % matrix was found to be good as compared to other two formulations and shows better controlled release of drug

An overview on NATURAL PRODUCT BASED AMYLOID PROTEIN INHIBITORS: NATURAL PRODUCT BASED AMYLOID PROTEIN INHIBITORS

Neurodegenerative disorders like Alzheimer’s are associated by plague formation of protein aggregates called amyloid proteins. Many natural based products like flavonoids, Phenolic acids, iso-flavones, polyunsaturated fatty acids play major role in therapeutic ability to degrade, slow down, recondition the amyloid protein (amyloid protein inhibitors). These compounds extracted from plants have shown consequential potential in invitro studies as well as in-vivo studies. For requisite for brain nutritive growth Omega 3 Fatty acids are important. Whereas ß-Carotene plays indispensable role in Cognitive Impairment and Oxidative Stress in the brain. It is described that Omega 3 fatty acids are extracted from the source (flaxseed) by oil press method and ß-Carotene is synthesized by physiochemical process from carrot. The main objective of this particular research topic is to provide more effectiveness in detaining the growth of amyloid protein inhibitors in brain. It is observed that the product with omega 3 and ß-Carotene slow down the protein aggregation more efficiently than omega 3 capsules alone and intra-cerebroventricular injected streptozotocin. This can be determined by In-silico activity of acetylcholinesterase. The analyses show extensive reciprocity between inhibitors and amyloid proteins. The administration of omega 3 with ß-Carotene depreciates the amyloid protein aggregates more efficiently. Hence it is suggested that the product can be used as treatment for neurodegenerative diseases like Alzheimer’s

Larvicidal activity of CuO and ZnO nanoparticles against Aedes aegypti and Anopheles stephensi mosquito vectors-a greener approach by Phaseolus vulgaris L. aqueous extract as bio-reductant

In order to eradicate mosquito-borne diseases like malaria, chikungunya, dengue, and Zika virus which are mostly found in temperate zones, synthetic pesticides are widely used as a form of fumigation. This has resulted in a rise in mosquito-borne disease transmission dynamics and a substantial rise in atmospheric pollution. In light of this, the current work used an aqueous extract of Phaseolus vulgaris to formulate bioencapsulated CuO and ZnO NPs to combat mosquito vectors. The synthesized CuO and ZnO NPs were characterized using UV–visible, XRD, FT-IR, FE-SEM & EDX, AFM, and DLS techniques. According to analytical characterization, the CuO and ZnO NPs had monoclinic and hexagonal crystallites with average sizes of 13.7 nm and 185 nm, respectively. FE-SEM analysis confirms the spherical and flower-like morphology of CuO and ZnO NPs and their respective elemental composition was identified by EDX studies. The average particle size of CuO and ZnO NPs was determined to be 22.6 nm and 662 nm. CuO and ZnO NPs possessed zeta potential values of −23.2 mV and −29.7 mV respectively. The larvae of the malaria vector Anopheles stephensi and the dengue vector Aedes aegypti were subjected to compare the larvicidal bioassays in a range of concentrations of P. vulgaris aqueous extract with methanol extracts, and CuO NPs with ZnO NPs (6.25, 12.5, 25, 50, 100 µg/mL). The results showed the larvicidal activity of the aqueous extract is superior to the methanol extract and ZnO NPs are superior to the CuO NPs. This study further revealed that Aedes aegypti vulnerable than Anopheles stephensi to a given concentration of crude aqueous, methanol extracts of P. vulgaris and to CuO and ZnO NPs. The overall findings of this research demonstrated the feasibility of using these biosynthesized nanoparticles as highly effective, eco-friendly natural mosquito control pesticides

Plant-based carbon dots are a sustainable alternative to conventional nanomaterials for biomedical and sensing applications

Carbon dots are small carbon-based particles with unique properties that make them useful in various applications. Some advantages include low toxicity, bio-compatibility, excellent photo luminescence, high stability, and ease of synthesis. These features make them promising for biomedical imaging, drug delivery, and optoelectronic devices. Carbon dots derived from plants have several advantages, including their low toxicity, biocompatibility, and renewable sources. They also have excellent water solubility and high stability and can be easily synthesized using simple and low-cost methods. These properties make them promising candidates for various biomedicine, sensing, and imaging applications. Plant-based carbon dots have shown great potential in metal sensing and bio-imaging applications. They can act as efficient sensors for detecting heavy metals due to their strong chelation and fluorescence properties. This article showcases plant-based carbon dots, emphasizing their low toxicity, biocompatibility, renewability, and potential in metal sensing and bio-imaging. It aims to illustrate their versatile applications and ongoing research for broader use. The current investigation explores their full potential and develops new synthesis and application methods