An In Vitro Evaluation of the Effects of Air-Polishing Powders on Sound and Demineralised Enamel.

AIM To evaluate the effects of two air-polishing powders, during orthodontic treatment, on the surface roughness of sound and demineralised enamel. MATERIALS AND METHODS Forty-two caries-free human molars were collected, and the enamel surfaces were flattened and polished. Teeth were assigned to two groups (n = 21 each), a sound- and a demineralised-enamel group (subjected to pH-cycling over 2 weeks to create artificially induced white spot-like lesions). Within each group, teeth were further assigned to three groups (n = 7 each), air polished with either sodium bicarbonate, erythritol, or a negative control (water). Each sample was treated for 5 and 150 s. The average surface roughness (Ra) for each sample was measured using white-light-sensor profilometry. RESULTS On sound enamel, the Ra was roughly 0.17 ± 0.07 μm. After 150 s of air polishing, the Ra increased with erythritol (by 0.28 μm), and even more so with bicarbonate treatment (by 0.68 μm) (p < 0.01). On demineralised enamel, the Ra was roughly 0.79 ± 0.56 μm. The Ra increased after 5 s of air-polishing treatment similarly with erythritol and bicarbonate powders (by 1.03 μm and 1.04 μm, respectively) (p = 0.025), and even more after 150 s (by 2.48 μm and 2.49 μm, respectively) (p < 0.001). CONCLUSIONS On white spot lesions, one should be aware that enamel surface roughness will increase with both erythritol and bicarbonate air-polishing powders, especially with longer exposure times

Trajectories of humoral and cellular immunity and responses to a third dose of mRNA vaccines against SARS-CoV-2 in patients with a history of anti-CD20 therapy.

BACKGROUND The majority of patients with B-cell-depleting therapies show compromised vaccination-induced immune responses. Herein, we report on the trajectories of anti-SARS-CoV-2 immune responses in patients of the RituxiVac study compared with healthy volunteers and investigate the immunogenicity of a third vaccination in previously humoral non-responding patients. METHODS We investigated the humoral and cell-mediated immune response after SARS-CoV-2 messanger RNA vaccination in patients with a history with anti-CD20 therapies. Coprimary outcomes were antispike and SARS-CoV-2-stimulated interferon-γ concentrations in vaccine responders 4.3 months (median; IQR: 3.6-4.8 months) after first evaluation, and humoral and cell-mediated immunity (CMI) after a third vaccine dose in previous humoral non-responders. Immunity decay rates were compared using analysis of covariance in linear regression. RESULTS 5.6 months (IQR: 5.1-6.7) after the second vaccination, we detected antispike IgG in 88% (29/33) and CMI in 44% (14/32) of patients with a humoral response after two-dose vaccination compared with 92% (24/26) healthy volunteers with antispike IgG and 69% (11/16) with CMI 6.8 months after the second vaccination (IQR: 6.0-7.1). Decay rates of antibody concentrations were comparable between patients and controls (p=0.70). In two-dose non-responders, a third SARS-CoV-2 vaccine elicited humoral responses in 19% (6/32) and CMI in 32% (10/31) participants. CONCLUSION This study reveals comparable immunity decay rates between patients with anti-CD20 treatments and healthy volunteers, but inefficient humoral or CMI after a third SARS-CoV-2 vaccine in most two-dose humoral non-responders calling for individually tailored vaccination strategies in this population.Trial registration numberNCT04877496; ClinicalTrials.gov number

In vivo shell-like fractures of veneered-ZrO2 fixed dental prostheses

Fractographic analyses are performed in two fixed dental prosthetic reconstructions made of ZrO2 frameworks covered by a veneering ceramic that fractured during function in the mouth. Processing histories, material properties, recovered broken parts and replicas of the fracture surface were used, along with fractographic markings to determine fracture origins and cause of failure. A shell-like fracture pattern was found common for both cases, although different factors were identified to be involved in each fracture event. Internal thermal residual stresses and occlusal surface defects from localized contact overloading were found to precipitate the fracture in Case 1, whereas extreme occlusal surface damage from sliding chewing contact was determinant in the fracture of Case 2. The interface between the veneering ceramic and the ZrO2 framework was unaffected by the fractures

Fracture of a veneered-ZrO2 dental prosthesis from an inner thermal crack

AbstractHere we describe the fractographic analysis of a veneer-ZrO2 single-unit dental prosthesis that fractured in a shell-like manner. Analysis of the retrieved fragment revealed that the crack originated in the bulk of the veneer from a thermal flaw located between two layers of the veneering material. Using the measured flaw plane we showed that the conditions of loading at fracture were complex and probably involved important tangential components

Fractal analysis at varying locations of clinically failed zirconia dental implants

Previous studies have shown that the fracture toughness of ceramics can be determined from the fractal dimensions (D) of their fracture surfaces and that the surface should be leveled to obtain an accurate D measurement. This study was to determine the effects of leveling operations and distance from the failure origin on the D values