10 research outputs found
Feasibility of combined upper and lower gastrointestinal endoscopic biopsy in the common marmoset (Callithrix jacchus) to evaluate gastrointestinal diseases
Background: Chronic gastroenteropathies, including gluten sensitivity and marmoset
wasting syndrome, frequently occur in captive colonies of common marmosets
(Callithrix jacchus). Early identification and diagnosis of affected animals are desirable.
Endoscopic examination of the colon in marmosets is described, but the small
intestine can harbor significant mucosal lesions not representing those in the colon.
Evaluating the small intestine currently requires invasive surgical biopsies due to the
small patient size, carrying a risk of severe complications.
Methods: Endoscopic intubation and multisite biopsy of the duodenum/proximal jejunum
are demonstrated in 10 marmosets under general anesthesia.
Results: Esophagogastroduodenoscopy with colonoscopy efficiently aid in examining
the gastrointestinal tract and obtaining an antemortem histologic diagnosis in marmosets
with chronic gastrointestinal signs.
Conclusions: This minimally invasive technique is feasible in marmosets. Future investigations
into the pathogenesis of chronic gastroenteropathies will benefit from these
data, leading to improved animal welfare and better individual and colony health
management
Heterogeneous perfusion is a consequence of uniform shear stress in optimized arterial tree models
Using optimized computer models of arterial trees we demonstrate that flow heterogeneity is a necessary consequence of a uniform shear stress distribution. Model trees are generated and optimized under different modes of boundary conditions. In one mode flow is delivered to the tissue as homogeneously as possible. Although this primary goal can be achieved, resulting shear stresses between blood and the vessel walls show very large spread. In a second mode, models are optimized under the condition of uniform shear stress in all segments which in turn renders flow distribution heterogeneous. Both homogeneous perfusion and uniform shear stress are desirable goals in real arterial trees but each of these goals can only be approached at the expense of the other. While the present paper refers only to optimized models, we assume that this dual relation between the heterogeneities in flow and shear stress may represent a more general principle of vascular systems
Feasibility of combined upper and lower gastrointestinal endoscopic biopsy in the common marmoset (Callithrix jacchus) to evaluate gastrointestinal diseases
Background: Chronic gastroenteropathies, including gluten sensitivity and marmoset
wasting syndrome, frequently occur in captive colonies of common marmosets
(Callithrix jacchus). Early identification and diagnosis of affected animals are desirable.
Endoscopic examination of the colon in marmosets is described, but the small
intestine can harbor significant mucosal lesions not representing those in the colon.
Evaluating the small intestine currently requires invasive surgical biopsies due to the
small patient size, carrying a risk of severe complications.
Methods: Endoscopic intubation and multisite biopsy of the duodenum/proximal jejunum
are demonstrated in 10 marmosets under general anesthesia.
Results: Esophagogastroduodenoscopy with colonoscopy efficiently aid in examining
the gastrointestinal tract and obtaining an antemortem histologic diagnosis in marmosets
with chronic gastrointestinal signs.
Conclusions: This minimally invasive technique is feasible in marmosets. Future investigations
into the pathogenesis of chronic gastroenteropathies will benefit from these
data, leading to improved animal welfare and better individual and colony health
management
Feasibility of combined upper and lower gastrointestinal endoscopic biopsy in the common marmoset (Callithrix jacchus) to evaluate gastrointestinal diseases
Background: Chronic gastroenteropathies, including gluten sensitivity and marmoset
wasting syndrome, frequently occur in captive colonies of common marmosets
(Callithrix jacchus). Early identification and diagnosis of affected animals are desirable.
Endoscopic examination of the colon in marmosets is described, but the small
intestine can harbor significant mucosal lesions not representing those in the colon.
Evaluating the small intestine currently requires invasive surgical biopsies due to the
small patient size, carrying a risk of severe complications.
Methods: Endoscopic intubation and multisite biopsy of the duodenum/proximal jejunum
are demonstrated in 10 marmosets under general anesthesia.
Results: Esophagogastroduodenoscopy with colonoscopy efficiently aid in examining
the gastrointestinal tract and obtaining an antemortem histologic diagnosis in marmosets
with chronic gastrointestinal signs.
Conclusions: This minimally invasive technique is feasible in marmosets. Future investigations
into the pathogenesis of chronic gastroenteropathies will benefit from these
data, leading to improved animal welfare and better individual and colony health
management
Feasibility of combined upper and lower gastrointestinal endoscopic biopsy in the common marmoset (Callithrix jacchus) to evaluate gastrointestinal diseases
Background: Chronic gastroenteropathies, including gluten sensitivity and marmoset
wasting syndrome, frequently occur in captive colonies of common marmosets
(Callithrix jacchus). Early identification and diagnosis of affected animals are desirable.
Endoscopic examination of the colon in marmosets is described, but the small
intestine can harbor significant mucosal lesions not representing those in the colon.
Evaluating the small intestine currently requires invasive surgical biopsies due to the
small patient size, carrying a risk of severe complications.
Methods: Endoscopic intubation and multisite biopsy of the duodenum/proximal jejunum
are demonstrated in 10 marmosets under general anesthesia.
Results: Esophagogastroduodenoscopy with colonoscopy efficiently aid in examining
the gastrointestinal tract and obtaining an antemortem histologic diagnosis in marmosets
with chronic gastrointestinal signs.
Conclusions: This minimally invasive technique is feasible in marmosets. Future investigations
into the pathogenesis of chronic gastroenteropathies will benefit from these
data, leading to improved animal welfare and better individual and colony health
managemen