Impact of post-game result in the mood state in young women soccer players

En: Investigación psicodidáctica y mejora educativa = ikerkuntza psikodidaktikoa eta hezkuntza hobekuntza (No publicado) - 11 p.[ES] El empoderamiento de las mujeres y el cambio de valores en nuestra sociedad llevan a los poderes políticos a tomar decisiones para que el desarrollo de las mujeres en su vida personal y profesional sea una realidad. El deporte puede en ciertas condiciones ser un eje privilegiado para disminuir la desigualdad entre hombres y mujeres. El desafío de la igualdad en el deporte no es solo un desafío « interno » sino una oportunidad social. En los últimos años se constata un aumento de la práctica de deporte por parte de la mujer, y más en concreto en lo que actualmente se considera como el deporte rey, el fútbol. En este estudio se ha examinado las relaciones entre las dimensiones de los estados de ánimo (tensión, hostilidad, depresión, vigor y fatiga) que se generan en jóvenes jugadoras de futbol en las post competiciones en relación al resultado.[EN] The empowerment of women and the change of values in our society take political power to make decisions for the development of women in their personal and professional lives is a reality. Sport can under certain conditions be a priority means to reduce inequality between men and women. The challenge of equality in sport is not only a challenge 'internal' but a social opportunity. In recent years has been noticed an increase of women practicing sports, and more specifically on what is currently considered as the most popular sport, soccer. This research has studied the connection between the dimensions of the states of mood (tension, hostility, depression, vigour and fatigue) generated in young soccer players in the post competition in relation to the result

Staphylococcus epidermidis strains isolated from breast milk of women suffering infectious mastitis: potential virulence traits and resistance to antibiotics

<p>Abstract</p> <p>Background</p> <p>Although <it>Staphylococcus aureus </it>is considered the main etiological agent of infectious mastitis, recent studies have suggested that coagulase-negative staphylococci (CNS) may also play an important role in such infections. The aims of this work were to isolate staphylococci from milk of women with lactational mastitis, to select and characterize the CNS isolates, and to compare such properties with those displayed by CNS strains isolated from milk of healthy women.</p> <p>Results</p> <p>The milk of 30 women was collected and bacterial growth was noted in 27 of them, of which <it>Staphylococcus epidermidis </it>was isolated from 26 patients and <it>S. aureus </it>from 8. Among the 270 staphylococcal isolates recovered from milk of women with mastitis, 200 were identified as <it>Staphylococcus epidermidis </it>by phenotypic assays, species-specific PCR and PCR sequencing. They were typified by pulsed field gel electrophoresis (PFGE) genotyping. The PFGE profiles of the <it>S. epidermidis </it>strains were compared with those of 105 isolates from milk of healthy women. A representative of the 76 different PFGE profiles was selected to study the incidence of virulence factors and antibiotic resistance. The number of strains that contained the biofilm-related <it>ica</it>D gene and that showed resistance to oxacillin, erythromycin, clindamycin and mupirocin was significantly higher among the strains isolated from mastitic milk.</p> <p>Conclusion</p> <p><it>S. epidermidis </it>may be a frequent but largely underrated cause of infectious mastitis in lactating women. The resistance to diverse antibiotics and a higher ability to form biofilms found among the strains isolated from milk of women suffering mastitis may explain the chronic and/or recurrent nature of this infectious condition.</p

Staphylococcus epidermidis: A differential trait of the fecal microbiota of breast-fed infants

<p>Abstract</p> <p>Background</p> <p>Breast milk is an important source of staphylococci and other bacterial groups to the infant gut. The objective of this work was to analyse the bacterial diversity in feces of breast-fed infants and to compare it with that of formula-fed ones. A total of 23 women and their respective infants (16 breast-fed and 7 formula-fed) participated in the study. The 16 women and their infants provided a sample of breast milk and feces, respectively, at days 7, 14, and 35. The samples were plated onto different culture media. Staphylococcal and enterococcal isolates were submitted to genetic profiling and to a characterization scheme, including detection of potential virulence traits and sensitivity to antibiotics.</p> <p>Results</p> <p>The feeding practice had a significant effect on bacterial counts. A total of 1,210 isolates (489 from milk, 531 from breast-fed and 190 from formula-fed infants) were identified. <it>Staphylococcus epidermidis </it>was the predominant species in milk and feces of breast-fed infants while it was less prevalent in those of formula fed-infants. <it>Enterococcus faecalis </it>was the second predominant bacterial species among the fecal samples provided by the breast-fed infants but it was also present in all the samples from the formula-fed ones. The biofilm-related <it>icaD </it>gene and the <it>mecA </it>gene were only detected in a low number of the <it>S. epidermidis </it>strains. Several enterococcal isolates were also characterized and none of them contained the <it>cylA </it>or the <it>vanABDEG </it>antibiotic-resistance genes. All were sensitive to vancomycin.</p> <p>Conclusion</p> <p>The presence of <it>S. epidermidis </it>is a differential trait of the fecal microbiota of breast-fed infants. Globally, the staphyloccal isolates obtained from milk and feces of breast-fed infants contain a low number of virulence determinants and are sensitive to most of the antibiotics tested.</p

Impacto del resultado post-partido en la ansiedad cognitiva, ansiedad somática y la autoconfianza en jóvenes jugadoras de fútbol

22 p. - Publicado en CD-ROMEl presente estudio analiza el impacto que tiene el resultado post-partido en la ansiedad cognitiva, ansiedad somática y la autoconfianza en jóvenes jugadoras de fútbol. Una muestra de 45 jóvenes futbolistas mujeres completaron la traducción realizada por Capdevila (1997) al castellano de la versión en inglés del Inventario de Ansiedad Competitiva en el Deporte (CSAI-2) (Martens et al., 1990), cuestionario que evalúa los componentes cognitivos y somáticos de la ansiedad estado y la autoconfianza con relación a la ejecución deportiva referida a la competición. Los resultados muestran que el resultado afecta claramente a la autoconfianza de las jugadoras. Cuando el resultado es de derrota las puntuaciones de la Autoconfianza disminuyen significativamente. Por su parte las dos dimensiones de la ansiedad (cognitiva y somática) se mantienen estables independientemente del resultado del partido

GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells: Contribution to prostate cancer progression.

In prostate cancer (PCa), neuroendocrine cells (NE) have been associated with the progression of the disease due to the secretion of neuropeptides that are capable of diffusing and influence surrounding cells. The GABAergic system is enriched in NE-like cells, and contributes to PCa progression. Additionally, γ-aminobutyric acid (GABA) stimulates the secretion of gastrin-releasing peptide (GRP) in peripheral organs. For the first time, in this study we show the role of GABA and GABAB receptor 1 (GABBR1) expression in GRP secretion in NE-like prostate cancer cells. We demonstrated an increase in GRP levels in NE-like cell medium treated with GABAB receptor agonist. Moreover, the blocking of this receptor inhibited GABA-induced GRP secretion. The invasive potential of PC3 cells was enhanced by either GRP or conditioned medium of NE-like cells treated with GABA. Additionally, we confirmed a positive correlation between GABA and GRP levels in the serum of PCa patients with NE markers. Finally, using public available data sets, we found a negative correlation between GABBR1 and androgen receptor (AR) expression, as well as a strong positive correlation between GABBR1 and enolase 2. These results suggest that GABA via GABBR1 induces GRP secretion in NE like cells involved in PCa progression

Replacement of Metaphylactic Antimicrobial Therapy by Oral Administration of Ligilactobacillus salivarius MP100 in a Pig Farm

Antibiotic use in swine production contributes to the emergence and spread of resistant bacteria, which poses a threat on human health. Therefore, alternative approaches must be developed. The objective of this work was the characterization of the probiotic properties of a Ligilactobacillus salivarius strain isolated from sow's milk and its application as an inoculated fermented feed to pregnant sows and piglets. The study was carried in a farm in which metaphylactic use of antimicrobials (including zinc oxide) was eliminated at the time of starting the probiotic intervention, which lasted for 2 years. Feces from 8-week-old piglets were collected before and after the treatment and microbiological and biochemical analyses were performed. The procedure led to an increase in the concentrations of clostridia and lactobacilli-related bacteria. Parallel, an increase in the concentration of butyrate, propionate and acetate was observed and a notable reduction in the presence of antibiotic resistant lactobacilli became apparent. In conclusion, replacement of antimicrobials by a microbiota-friendly approach was feasible and led to positive microbiological and biochemical changes in the enteric environment

Administration of Ligilactobacillus salivarius CECT 30632 to elderly during the COVID-19 pandemic: Nasal and fecal metataxonomic analysis and fatty acid profiling

Elderly was the most affected population during the first COVID-19 and those living in nursing homes represented the most vulnerable group, with high mortality rates, until vaccines became available. In a previous article, we presented an open-label trial showing the beneficial effect of the strain Ligilactobacillus salivarius CECT 30632 (previously known as L. salivarius MP101) on the functional and nutritional status, and on the nasal and fecal inflammatory profiles of elderly residing in a nursing home highly affected by the pandemic. The objective of this post-hoc analysis was to elucidate if there were changes in the nasal and fecal bacteriomes of a subset of these patients as a result of the administration of the strain for 4 months and, also, its impact on their fecal fatty acids profiles. Culture-based methods showed that, while L. salivarius (species level) could not be detected in any of the fecal samples at day 0, L. salivarius CECT 30632 (strain level) was present in all the recruited people at day 120. Paradoxically, the increase in the L. salivarius counts was not reflected in changes in the metataxonomic analysis of the nasal and fecal samples or in changes in the fatty acid profiles in the fecal samples of the recruited people. Overall, our results indicate that L. salivarius CECT 30632 colonized, at least temporarily, the intestinal tract of the recruited elderly and may have contributed to improvements in their functional, nutritional, and immunological status, without changing the general structure of their nasal and fecal bacteriomes when assessed at the genus level. They also suggest the ability of low abundance bacteria to train immunity

ENTRENAMIENTO CONDUCTUAL EN HABILIDADES DE COMUNICACIÓN SEXUAL EN LA PAREJA Y USO CORRECTO DEL CONDÓN

This study assessed the effects of sexual communication and condom use skills training on 50 sexually active college students’ consistent condom use. In vivo sexual communication and condom use skills postintervention assessments showed that intervention group participants acquired the skills trained and were significantly better than control group participant in openly talking about sex (pEl presente estudio evalúa los efectos de un entrenamiento conductual en habilidades de comunicación sexual en la pareja y uso correcto del condón sobre la consistencia en el uso del condón en una muestra de 50 estudiantes universitarios sexualmente activos. En la postevaluación de las variables medidas a través de la observación directa se encontró una ejecución significativamente más alta en el grupo de intervención que la obtenida en el grupo control en la habilidad para iniciar y mantener una conversación sobre sexualidad (

Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipshycotics

In previous work we developed a pharmacogenetic predictor of antipsychotic (AP) induced extrapyramidal symptoms (EPS) based on four genes involved in mTOR regulation. The main objective is to improve this predictor by increasing its biological plausibility and replication. We re-sequence the four genes using next-generation sequencing. We predict functionality 'in silico' of all identified SNPs and test it using gene reporter assays. Using functional SNPs, we develop a new predictor utilizing machine learning algorithms (Discovery Cohort, N = 131) and replicate it in two independent cohorts (Replication Cohort 1, N = 113; Replication Cohort 2, N = 113). After prioritization, four SNPs were used to develop the pharmacogenetic predictor of AP-induced EPS. The model constructed using the Naive Bayes algorithm achieved a 66% of accuracy in the Discovery Cohort, and similar performances in the replication cohorts. The result is an improved pharmacogenetic predictor of AP-induced EPS, which is more robust and generalizable than the original

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

Certain dietary interventions might improve the therapeutic index of cancer treatments. An alternative to the "drug plus diet" approach is the pharmacological reproduction of the metabolic traits of such diets. Here we explored the impact of adding metformin to an established therapeutic regimen on the systemic host metabolism of cancer patients. A panel of 11 serum metabolites including markers of mitochondria! function and intermediates/products of folate-dependent one-carbon metabolism were measured in paired baseline and post-treatment sera obtained from HER2-positive breast cancer patients randomized to receive either metformin combined with neoadjuvant chemotherapy and trastuzumab or an equivalent regimen without metformin. Metabolite profiles revealed a significant increase of the ketone body beta-hydroxybutyrate and of the TCA intermediate alpha-ketoglutarate in the metformin-containing arm. A significant relationship was found between the follow-up levels of homocysteine and the ability of treatment arms to achieve a pathological complete response (pCR). In the metformin-containing arm, patients with significant elevations of homocysteine tended to have a higher probability of pCR. The addition of metformin to an established anticancer therapeutic regimen causes a fasting-mimicking modification of systemic host metabolism. Circulating homocysteine could be explored as a clinical pharmacodynamic biomarker linking the antifolate-like activity of metformin and biological tumor response