The Vignette Method: A Flexibile Method for Capstone Courses and as a Supplemental Learning Experience in Research Labs

Many departments in colleges and universities require a capstone course that involves the students conducting a research project. This author has had over 20 years of experience teaching such a capstone course and describes a flexible research method for student research projects – the vignette study (an experiment embedded in a survey). She also has teams of undergraduate students working in her lab for research credit make progress on a vignette design as one of several research activities. The vignette study can be used for students across many majors, including but not limited to sociology, psychology, criminal justice, nursing, social work, and marketing. Detail is provided on how to teach a capstone course using this flexible research method

Effects of Triclopyr on Variable-Leaf Watermilfoil

The objective of the study described here was to determine the effect on variable-leaf watermilfoil of various combinations of triclopyr concentrations and exposure times using dosage rates that controlled Eurasian watermilfoil under laboratory and field conditions (Netherland and Getsinger 1992, Getsinger et al. 1997, Petty et al. 1998)

Self-disclosure in intimate relationships: Associations with individual and relationship characteristics over time

Self-disclosure is an act of intimacy and serves as a maintenance strategy, and yet very little prior research has examined self-disclosure within relationships with data collected multiple times over an extended period of time and from both partners. With longitudinal data collected from both partners in young adult dating couples, we examined how self-disclosure is associated with both individual characteristics (e.g., responsiveness, self-esteem) and relationship characteristics (satisfaction, love, commitment). Overall, men and women indicated a similar high level of self-disclosure. As hypothesized, positive associations were found between self-disclosure and the individual characteristics of self-esteem, relationship esteem (confidence as an intimate partner), and responsiveness (as indicated by data collected at Time 1). Self-disclosure also was positively associated with relationship quality (satisfaction, love, and commitment). Similar positive associations were typically found at the follow-up waves, although in many cases the correlations were not significant and were more modest in magnitude. Level of self-disclosure was generally not predictive of whether the couple stayed together or broke up over time, although the more that women perceived their partner disclosed at Time 1, the less likely the couple was to break up by Time 2. It is speculated that the generally high level of self-disclosure at Time 1 for the entire sample limited the degree to which self-disclosure could predict which relationships stayed together and which broke up over time. In an analysis that involved the subsample of couples who stayed together thoughout the study (many of whom married by Time 5), no significant change was found in levels of self-disclosure

The Ursinus Weekly, November 1, 1965

Founders\u27 Day ceremony honors four outstanding women • Homecoming weekend: Parties, pageantry, parades • Alumni initiate 1 year fund drive • Young Democrats help with campaign in Collegeville • Curtain Club presents theater-in-the-round • Senate announces senior women get 1:00 permissions • Editorial: Where have all the writers gone • Students join TV production staff • Letters to the editor • Student concert season opens at the Academy • Coed writes dear grandfather • Intramural corner • UC hockey over Wilson • JV\u27s undefeated • Alfred swamps Bears • Soccer team edged 1-0 • Greek machines promote The candidates • A protest! It\u27s purpose?https://digitalcommons.ursinus.edu/weekly/1208/thumbnail.jp

The Ursinus Weekly, December 14, 1964

Enthusiastic Pooh audience hears A. A. Milne children\u27s play: Matinee by Curtain Club • Faculty accepts senate approved hours change • Chorus and soloists usher Christmas season with 27th annual Messiah: Students attend full afternoon rehearsal • Christmas activities fill last week of 1964: Robin Roberts at MSGA banquet; Women\u27s banquet; Dorms hold open house; Mrs. Helfferich\u27s party; Candlelight communion; Christmas dance • Greeks hosts to orphans in area parties • Richard P. Richter accepts duties as alumni secretary • Frosh plan cool Ice palace \u2765 • Bridge tourney on UC campus • Spirit of Christmas present • B-ball team splits two close ones, 60-59 and 70-71: Sloppiness and apathy big factors • ZX leads v-ball; Demas second • Wrestling team looks strong • UC girl confesses in dial-a-bride • Letters to the editor • Greek gleanings • Ursinus kitchen food preparation exposedhttps://digitalcommons.ursinus.edu/weekly/1237/thumbnail.jp

The Ursinus Weekly, November 9, 1964

Senior Ball, Friday, offers Camelot, Al Raymond band: Lord and Lady, permanent class officers to be announced • Graduate awards available from science foundation • Miller and Zucker review election returns, meaning • Museum director on American art to be Forum highlight: Dr. Turner to emphasize the 20th century • William Shaffer, vice-president UC Board of Directors, dies • Pancoast in State House to seek greater local power • Faculty action penalizes 4 with fines, demerits • Curtain Club selects cast for Winnie the Pooh production, schedules December showing • English Club to meet tonight • Editorial: Altruism at Ursinus • Life in the cow palace; An eyewitness account • Kaffee Klatsch hosts large crowd to discuss rights • A girl\u27s life at Ursinus: 1906 • Spotlight: UC abroad • Advice column • Bears belt Haverford 19-6 at Haverford homecoming: Tony Motto scores two touchdowns • Soccermen defeat LaSalle 5-2 • Hockey team wins biggest: W.C., best ever, falls 1-0; West Chester places 5 on all-stars, Ursinus team effort proves supreme • Wrestling to start Tuesday • U.C. men\u27s mooning team suffers setback at hands of faculty • 200 dance to Okie Duke at Cafe Montmarte • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1233/thumbnail.jp

The Ursinus Weekly, November 23, 1964

Write me a murder, a skillful presentation of a weak play • Junior class announces \u27S no ball turnabout • WSGA report on women\u27s programs • Judy Collins to appear in campus folk concert: Performance tickets remain on sale • Ursinus receives $1,500 grant from Sears-Roebuck Foundation • Work camps topic of slide lecture • Debaters prepare for Temple novice tournament • Ursinus students attend Sheraton collegiate council • Human Relations Commission starts tutoring program • SWC abandons Sunday vespers • Editorial: Hats off! • Progress keyword in dining hall construction • Annual college music competition • Spotlight: UC abroad; Student\u27s stay in Stockholm • Letters to the editor • Advice column • U.C. history: The pipe dream • Volleyball league begins • Soccermen split 0-5 and 4-3 • Soccermen finish season with 5-5-1 record • UC drops final game to F&M, 20-6 • Bible fellowship sponsors Paul Little, speaker • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1235/thumbnail.jp

Cell-cell adhesion proteins in melanocytic pilomatrix carcinoma

Tumors of the matrix of rigid structures include matrical tumors of the hairs, nails, and teeth. These tumors share similar phenotypical and signaling features. Although benign matrical hair tumors are among the most common of these tumors, hair matrix tumors containing pigmented melanocytes are very rare. The malignant variant called melanocytic pilomatrix carcinoma contains benign colonizing dendritic melanocytes admixed with the carcinomatous follicular matrical cells

Identification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers

Clear cell ovarian cancer is an epithelial ovarian cancer histotype that is less responsive to chemotherapy and carries poorer prognosis than serous and endometrioid histotypes. Despite this, patients with these tumors are treated in a similar fashion as all other ovarian cancers. Previous genomic analysis has suggested that clear cell cancers represent a unique tumor subtype. Here we generated the first whole genomic expression profiling using epithelial component of clear cell ovarian cancers and normal ovarian surface specimens isolated by laser capture microdissection. All the arrays were analyzed using BRB ArrayTools and PathwayStudio software to identify the signaling pathways. Identified pathways validated using serous, clear cell cancer cell lines and RNAi technology. In vivo validations carried out using an orthotopic mouse model and liposomal encapsulated siRNA. Patient-derived clear cell and serous ovarian tumors were grafted under the renal capsule of NOD-SCID mice to evaluate the therapeutic potential of the identified pathway. We identified major activated pathways in clear cells involving in hypoxic cell growth, angiogenesis, and glucose metabolism not seen in other histotypes. Knockdown of key genes in these pathways sensitized clear cell ovarian cancer cell lines to hypoxia/glucose deprivation. In vivo experiments using patient derived tumors demonstrate that clear cell tumors are exquisitely sensitive to antiangiogenesis therapy (i.e. sunitinib) compared with serous tumors. We generated a histotype specific, gene signature associated with clear cell ovarian cancer which identifies important activated pathways critical for their clinicopathologic characteristics. These results provide a rational basis for a radically different treatment for ovarian clear cell patients