EMAIL SCANNING OPTIMIZATION TECHNIQUES

Typically, a Secure Mailbox (SM) or Secure Email Gateway (SEG) that receives emails for an organization scans emails and performs threat detection/handling for the emails (e.g., allowing or dropping emails) based on various handling policies configured for the organization. Currently, an SM/SEG completely scans all email each time an email traverses the SM/SEG (e.g., for an initial email and any subsequent replies/responses for a conversation/email thread), which can result in high usage of compute resources for an organization, potentially increasing the cost of email services, as well as increasing the latency of email delivery. In order to address such issues, techniques presented herein provide for the ability to prevent repeat scanning of email content that has already been scanned for a given conversation thread, which can be identified using a message identifier (M-ID), and to correlate results of previous scans of the conversation thread with a current scan of the thread (having a same message ID) in order to perform threat detection for emails

A cross-sectional study on quality of life among acne vulgaris patients

Background: In India, prevalence data from dermatology clinic in a teaching hospital in Varanasi reported acne in 50.6% of boys and 38.13% of girls in the age group 12-17 years. Though it is considered to be merely a cosmetic problem, it is associated with considerable psychological impairment which is comparable with certain chronic diseases. Acne patients are prone to low self-esteem, low self-confidence and social dysfunction which may lead to anxiety, depression, obsessive compulsiveness and sometimes suicidal ideation. Acne affects the functional abilities of individuals and patients have higher rate of unemployment when compared to those without acne. Acne also may have negative impact on personal relationships, sports activities and employment opportunities in teens and young adults. The management of acne must take into account the impact of acne on the patient’s quality of life. So the present study was carried out to determine the impact of acne and its clinical severity on quality of life among patients of different grades of acne patients in various age groups.Methods: The current cross sectional study was conducted in Patients diagnosed as acne vulgaris attending OPD of PCMS and RC Bhopal (India) in department of dermatology for a period of 2 year. (November 2012 – October 2014). 300 patients attending the Dermatology OPD with diagnosis of acne vulgaris were taken for the study. Patients aged 16 -35 years were included in our study. A detailed history was taken after obtaining consent from all the participants of study. Cardiff Acne disability index (CADI) and Dermatology life quality index (DLQI) were administered on patients to determine the impact of acne vulgaris on quality of life (QOL). Data was analyzed to compare the quality of life indices (CADI and DLQI) for duration and severity of acne.Results: Mean age of study population was 20.69 years. There was a male preponderance with ratio of 1.04:1 (M:F). According to this study 49% of patients had acne vulgaris for less than 1year. In present study maximum number 63.7% of patients presented with lesions over face followed by 14.7% of patients having lesions over face and back. According to DLQI scores of acne showed no effect in 4.3% of the patients, small effect in 26.3% of the patients, moderate effect in 38.7% of patients, very large effect in 29% of patients and extremely large effects on 1.7% of patients. According to CADI scores of acne showed low effect in 31.3% of the patients, majority had medium effect in 56.7% of patients and high effect was seen on 12 % of patients.Conclusions: Overall our study showed that quality of life is significantly impaired in patients of severe acne vulgaris. Use of these simple QOL measures as a part of integral clinical strategy will improve the outcome

A BRIEF KNOWLEDGE OF BANAFSHA (VIOLA ODORATA LINN.) & OTHER VIOLA SPECIES

All over the world Viola genus in the Violet family Violaceae is broadly distributed. It is the largest genus in the family containing 500 species. Products isolated from them as are- Essential oils, Glycosides (Iridin, Violaquercitrin, Violutoside), Carbohydrate (Inulin), Ester (Methyl salicylate), Mustard oil (Phenyl ethyl), Colouring matters (Luteolin, Quercetin) etc. Importance of Violaceae family in traditional medicines has been mentioned. Many medicinal herbs used for therapeutic applications such as act as blood purifier, treatment of bruises, ulcers, respiratory infections, renal disorders etc belong to this family. Viola odorata also known as sweet violet & it is a rich source of vitamin c. Traditionally is very much effective in jaundice, anti-inflammatory, anti-pyretic, anti bacterial, hepato-protective activity. Viola odorata syrup made from flower petals improves cough suppression in children with asthma. Intranasal administration of Viola odorata extract oil is sedative to the brain and is helpful in insomnia suffering patients. A Unani medicine named as Joshanda used in form of decoction for cough & colds contain this valuable herb. In Chinese system of medicine it has been prescribed against Cancerous growth. In France Viola syrup is used as cough remedy. Cultivation of Violets in England occurs largely Startford-upon-Avon for syrup formation, which when mixed with Almond oil used as laxative in children. In olden time it was believed that Viola flowers are beneficial for eyes. Traditional knowledge when tested Pharmacologically & Phyto-chemically it will give us new effective therapeutic agents. This article is compilation of different aspect of Viola odorata and other Viola species such as their botanical classification, morphological feature, geographical distribution, chemical constituents, pharmacological properties and ethno-medicinal uses.&nbsp

Emerging Opportunities and Challenges in Indian Carpet Industry

India is famous for handmade carpet producing country in the international market. Carpet industry is one of the most growing cottage industries in India. Major sharing of carpet manufacturing and export is from Bhadohi – Mirzapur which is also popular as carpet hub in the world wide. Bhadohi – Mirzapur is the carpet cluster in Uttar Pradesh. The sector is providing the job opportunity to lacs of people belonging to the weaker section and rural areas. Industry has also been playing vital role to stop these people from migrating to other places for earning their livings. The quantity of carpet export has also been increasing rapidly every year. The Carpet Industry is basically labour intensive and utilizes traditional techniques in production process which are generally not cost effective in nature which escalates the price of the product. There are tremendous opportunities in the industry to grown up with lot of challenges

An evaluation of human protein-protein interaction data in the public domain

BACKGROUND: Protein-protein interaction (PPI) databases have become a major resource for investigating biological networks and pathways in cells. A number of publicly available repositories for human PPIs are currently available. Each of these databases has their own unique features with a large variation in the type and depth of their annotations. RESULTS: We analyzed the major publicly available primary databases that contain literature curated PPI information for human proteins. This included BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome databases. The number of binary non-redundant human PPIs ranged from 101 in PDZBase and 346 in MIPS to 11,367 in MINT and 36,617 in HPRD. The number of genes annotated with at least one interactor was 9,427 in HPRD, 4,975 in MINT, 4,614 in IntAct, 3,887 in BIND and <1,000 in the remaining databases. The number of literature citations for the PPIs included in the databases was 43,634 in HPRD, 11,480 in MINT, 10,331 in IntAct, 8,020 in BIND and <2,100 in the remaining databases. CONCLUSION: Given the importance of PPIs, we suggest that submission of PPIs to repositories be made mandatory by scientific journals at the time of manuscript submission as this will minimize annotation errors, promote standardization and help keep the information up to date. We hope that our analysis will help guide biomedical scientists in selecting the most appropriate database for their needs especially in light of the dramatic differences in their content

Holographic dark energy through Kaniadakis entropy in non flat universe

By extending the standard holographic principle to a cosmological framework and combining the non-flat condition with the Kaniadakis entropy, we construct the non-flat Kaniadakis holographic dark energy model. The model employs Kaniadakis parameter $K$ and a parameter $c$. Derivation of the differential equation for KHDE density parameter to describe the evolutionary behavior of the universe is obtained. Such a differential equation could explain both the open as well as closed universe models. The classification based on matter and dark energy (DE) dominated regimes show that the KHDE scenario may be used to specify the Universe's thermal history and that a quintom regime can be encountered. For open and closed both the cases, we find the expressions for the deceleration parameter and the equation of state (EoS) parameter. Also, by varying the associated parameters, classical stability of the method is established. On considering the curvature to be positive, the universe favors the quintom behavior for substantially smaller values as opposed to the flat condition, when only quintessence is attained for such $K$ values. Additionally, we see a similar behavior while considering the curvature to be negative for such $K$ values. Therefore, adding a little bit of spatial geometry that isn't flat to the KHDE enhances the phenomenology while maintaining $K$ values at lower levels. To validate the model parameters, the most recent $30\;H(z)$ dataset measurements, in the redshift range $0.07 \leq z \leq 1.965$ are utilized. In addition, the distance modulus measurement from the current Union 2.1 data set of type Ia supernovae are employed.Comment: 17 pages, 12 figure

Cataract surgery in patients with Fuchs’ endothelial corneal dystrophy

Cataract surgery risks corneal decompensation in patients with Fuchs’ endothelial corneal dystrophy, but it can also be combined with endothelial keratoplasty to address the condition

A Review Approach on various form of Apriori with Association Rule Mining

Data mining is a computerized technology that uses complicated algorithms to find relationships in large databases Extensive growth of data gives the motivation to find meaningful patterns among the huge data. Sequential pattern provides us interesting relationships between different items in sequential database. Association Rules Mining (ARM) is a function of DM research domain and arise many researchers interest to design a high efficient algorithm to mine ass ociation rules from transaction database. Association Rule Mining plays a important role in the process of mining data for frequent pattern matching. It is a universal technique which uses to refine the mining techniques. In computer science and data min ing, Apriori is a classic algorithm for learning association rules Apriori algorithm has been vital algorithm in association rule mining. . Apriori alg orithm - a realization of frequent pattern matching based on support and confidence measures produced exc ellent results in various fields. Main idea of this algorithm is to find useful patterns between different set of data. It is a simple algorithm yet having man y drawbacks. Many researches have been done for the improvement of this algorithm. This paper sho ws a complete survey on few good improved approaches of Apriori algorithm. This will be really very helpful for the upcoming researchers to find some new ideas from these approaches. The paper below summarizes the basic methodology of association rules alo ng with the mining association algorithms. The algorithms include the most basic Apriori algorithm along with other algorithms such as AprioriTi d, AprioriHybrid

Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection

<p>Abstract</p> <p>Background</p> <p>Recent observations indicate potential role of transcription factor STAT3 in cervical cancer development but its role specifically with respect to HPV infection is not known. Present study has been designed to investigate expression and activation of STAT3 in cervical precancer and cancer in relation to HPV infection during cervical carcinogenesis. Established cervical cancer cell lines and prospectively-collected cervical precancer and cancer tissues were analyzed for the HPV positivity and evaluated for STAT3 expression and its phosphorylation by immunoblotting and immunohistochemistry whereas STAT3-specific DNA binding activity was examined by gel-shift assays.</p> <p>Results</p> <p>Analysis of 120 tissues from cervical precancer and cancer lesions or from normal cervix revealed differentially high levels of constitutively active STAT3 in cervical precancer and cancer lesions, whereas it was absent in normal controls. Similarly, a high level of constitutively active STAT3 expression was observed in HPV-positive cervical cancer cell lines when compared to that of HPV-negative cells. Expression and activity of STAT3 were found to change as a function of severity of cervical lesions from precancer to cancer. Expression of active pSTAT3 was specifically high in cervical precancer and cancer lesions found positive for HPV16. Interestingly, site-specific accumulation of STAT3 was observed in basal and suprabasal layers of HPV16-positive early precancer lesions which is indicative of possible involvement of STAT3 in establishment of HPV infection. In HPV16-positive cases, STAT3 expression and activity were distinctively higher in poorly-differentiated lesions with advanced histopathological grades.</p> <p>Conclusion</p> <p>We demonstrate that in the presence of HPV16, STAT3 is aberrantly-expressed and constitutively-activated in cervical cancer which increases as the lesion progresses thus indicating its potential role in progression of HPV16-mediated cervical carcinogenesis.</p