6-Formyl-2-meth­oxy-3-nitro­phenyl 4-toluene­sulfonate

In the title compound, C15H13NO7S, the inter­planar angle between the two aromatic rings is 26.04 (3)°. The crystal structure is stabilized by C—H⋯O interactions

2-(5,7-Dimeth­oxy-4-oxo-4H-chromen-2-yl)phenyl 4-toluene­sulfonate

In the crystal structure of the title compound, C24H20O7S, the chromone system makes a dihedral angle of 37.32 (7)° with the adjacent benzene ring. The chromone ring system and the tolyl ring are almost parallel, with a dihedral angle of 4.56 (9)°. The tolyl ring is twisted at an angle of 41.75 (6)° with respect to the benzene ring. Weak intra- and inter­molecular C—H⋯O inter­actions are observed

ഭക്ഷ്യസുരക്ഷയുടെയും ദാരിദ്ര്യ നിർമ്മാർജ്ജനത്തിന്റെയും പശ്ചാത്തലത്തിൽ സുസ്ഥിരമായ ചെറുകിട മത്സ്യമേഖല സുരക്ഷിതമാക്കുന്നതിനായി സ്വമേധയാ നടപ്പിലാക്കേണ്ട മാർഗ്ഗനിർദ്ദേശങ്ങൾ (Voluntary Guidelines for Securing Sustainable Small-Scale Fisheries in the Context of Food Security and Poverty Eradication)

ഭക്ഷ്യസുരക്ഷയുടെയും ദാരിദ്ര്യ നിർമ്മാർജ്ജനത്തിന്റെയും പശ്ചാത്തലത്തിൽ സുസ്ഥിരമായ ചെറുകിട മത്സ്യമേഖല സുരക്ഷിതമാക്കുന്നതിനായി സ്വമേധയാ നടപ്പിലാക്കേണ്ട മാർഗ്ഗനിർദ്ദേശങ്ങൾ Technical Consultation on International Guidelines for securing sustainable small scale fisheries Voluntary Guidelines for Securing Sustainable Small-scale Fisheries in the Context of Food Security and Poverty Eradicatio

Termoreverzibilni mukoadhezivni in situ hidrogel za oftalmičku primjenu: dizajniranje i optimizacija koristeći kombinaciju polimera

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 3336 ºC. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.Cilj rada bio je razvoj i optimizacija termoreverzibilnog sustava za isporuku lijekova koji gelira in situ. Sustav je napravljen na bazi Pluronic F 127, a sadrži moksifloksacin hidroklorid kao modelni lijek. U radu je primjenjeno 32 potpuno faktorijsko dizajniranje s dva polimera, Pluronic F 68 i Gelrite kao nezavisnim varijablama koji su kombinirani s Pluronic F 127. Kao zavisne varijable odabrane su temperatura geliranja, čvrstoća gela, jačina bioadhezije, viskoznost i in vitro oslobađanje lijeka nakon 1 i 10 h. Pronađeno je da Pluronic F 68 u kombinaciji s Pluronic F 127 ima značajan učinak na temperaturu geliranja u rasponu od 33 do 36 C. S druge strane, Gelrite ima povoljan učinak na jačinu bioadhezije, čvrstoću gela i oslobađanje lijeka. Razvijen je kvadratni matematički model pomoću kojeg se može predvidjeti temperatura geliranja, čvrstoća gela, jačina bioadhezije i oslobađanje ljekovite tvari

Do people who load their feet differently need insoles that have different stiffness?

Background: Plantar pressure reduction is an important aspect of diabetic foot management. However little information exists about the optimum cushioning properties of materials used in diabetic footwear as insoles/foot-beds. Numerical analyses have indicated that optimizing the material properties of footwear materials can improve their ability to reduce pressure. Aim: To investigate if the optimal insole stiffness would vary based on patients’ body mass (BM) in people with diabetic neuropathy. Method: Custom PU foams were produced using different ratios of chemical components to achieve a range of different stiffness. Uniform thickness (400 mm × 400 mm × 10 mm) foam sheets were produced with shore-A hardness between 3 and 45 and average(±stdev) increments of 5(±3). Standardized compression tests were performed for all 10 custom materials as well as for 3 commercially available foam materials used in diabetic footwear. Plantar pressure was measured during balanced standing on all custom material sheets for 4 diabetic neuropathic volunteers: 2 with BM of 49 kg ± 1 kg and 2 with BM of 73 kg ± 2 kg. Results: The maximum compressive force for 50% compression of the commercially available foams was similar to custom foams with 11–28 shore-A hardness. Peak plantar pressure was minimised for materials with shore-A hardness 6 and 11 in subjects with BM of 49 kg ± 1 kg and 73 kg ± 2 kg respectively. In all cases using softer or stiffer material (by 1 shore hardness increment) increased pressure by 24% ± 26% and 32% ± 34% respectively. Conclusions: Careful selection of insole/foot-bed stiffness can improve the pressure reduction capacity of diabetic footwear. Optimum material stiffness increased with the BM of the volunteers

Electromagnetic transition from the 4+^+ to 2+^+ resonance in 8^8Be measured via the radiative capture in 4^4He+4^4He

An earlier measurement on the 4$^+$ to 2$^+$ radiative transition in $^8$Be provided the first electromagnetic signature of its dumbbell-like shape. However, the large uncertainty in the measured cross section does not allow a stringent test of nuclear structure models. The present paper reports a more elaborate and precise measurement for this transition, via the radiative capture in the $^4$He+$^4$He reaction, improving the accuracy by about a factor of three. The {\it ab initio} calculations of the radiative transition strength with improved three-nucleon forces are also presented. The experimental results are compared with the predictions of the alpha cluster model and {\it ab initio} calculations.Comment: 5 pages and 7 figures, Submitted to Physical Review Letter

Impact of Additional Chromosomal Aberrations on the Disease Progression of Chronic Myelogenous Leukemia

The emergence of additional chromosomal abnormalities (ACAs) in Philadelphia chromosome/BCR-ABL1 positive chronic myeloid leukemia (CML), is considered to be a feature of disease evolution. However, their frequency of incidence, impact on prognosis and treatment response effect in CML is not conclusive. In the present study, we performed a chromosome analysis of 489 patients in different clinical stages of CML, using conventional GTG-banding, Fluorescent in situ Hybridization and Spectral Karyotyping. Among the de novo CP cases, ACAs were observed in 30 patients (10.20%) with lowest incidence, followed by IM resistant CP (16.66%) whereas in AP and BC, the occurrence of ACAs were higher, and was about 40.63 and 50.98%, respectively. The frequency of occurrence of ACAs were compared between the study groups and it was found that the incidence of ACAs was higher in BC compared to de novo and IM resistant CP cases. Likewise, it was higher in AP patients when compared between de novo and IM resistant CP cases, mirroring the fact of cytogenetic evolution with disease progression in CML. In addition, we observed 10 novel and 10 rare chromosomal aberrations among the study subjects. This study pinpoints the fact that the genome of advanced phase patients was highly unstable, and this environment of genomic instability is responsible for the high occurrence of ACAs. Treatment response analysis revealed that compared to initial phases, ACAs were associated with an adverse prognostic effect during the progressive stages of CML. This study further portrayed the cytogenetic mechanism of disease evolution in CML