Synthesis and antimicrobial activity of some hybrid 2-aryl-4-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine derivatives

238-246Some new hybrid 2-aryl-4-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepines have been synthesised which possessed the pyrazole and benzodiazepine heterocycles 2a-t. Antimicrobial evaluation of the synthesized compounds have been carried out against different strains of bacteria like E. coli, P. aeruginosa, S. aureus and S. pyogenes and fungal strains like C. albicans, A. niger and A. clavatus using serial dilution method. The newly synthesized compounds 2i, 2j, 2k, 2l, 2m, 2q and 2t have shown significant activity against the above mentioned strains. The reported compounds in the present paper are supported by IR, 1H and 13C NMR, and LC-MS spectral analysis

Synthesis and antimicrobial activity of some hybrid 2-aryl-4-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine derivatives

Some new hybrid 2-aryl-4-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepines have beensynthesised which possessed the pyrazole and benzodiazepine heterocycles 2a-t. Antimicrobial evaluation of the synthesizedcompounds have been carried out against different strains of bacteria like E. coli, P. aeruginosa, S. aureus and S. pyogenesand fungal strains like C. albicans, A. niger and A. clavatus using serial dilution method. The newly synthesized compounds2i, 2j, 2k, 2l, 2m, 2q and 2t have shown significant activity against the above mentioned strains. The reported compounds inthe present paper are supported by IR, 1H and 13C NMR, and LC-MS spectral analysis

Calcium alginate beads with entrapped iron oxide magnetic nanoparticles functionalized with methionine—a versatile adsorbent for arsenic removal

no. 3114/8/Fin./Sch.// 2018 UIDP/50006/2020A novel beads adsorbent, consisting of calcium alginate entrapped on magnetic nanoparti-cles functionalized with methionine (MFMNABs), was developed for effective elimination of arsenic from water. The material was characterized by FT-IR (Fourier Transform Infrared Spectroscopy), SEM (Scanning Electron Microscopic), XRD (X-ray Diffraction) and TEM (Transmission Electron Microscopy). The arsenic removal capacity of the material was studied by altering variables such as pH of the solution, contact time, adsorbent dose and adsorbate concentration. The maximal removal of As(III) was 99.56% under optimal conditions with an equilibrium time of 110 min and pH 7.0–7.5. The adsorption followed a second order kinetics and data best fitted the Langmuir isotherm with a correlation coefficient of R2 = 0.9890 and adsorption capacity (qm ) of 6.6533 mg/g. The thermodynamic study showed entropy change (∆S) and enthalpy change (∆H) to be 34.32 J mol−1 K and 5.25 kJ mol−1, respectively. This study proved that it was feasible to treat an As(III) solution with MFMNABs. The synthesized adsorbent was cost-effective, environmentally friendly and versatile, compared to other adsorbents. The adsorption study was carried by low cost spectrophotometric method using N-bromosuccinimide and rhodamine-B developed in our laboratory.publishersversionpublishe

Aloe Vera Functionalized Magnetic Nanoparticles Entrapped Ca Alginate Beads as Novel Adsorbents for Cu(II) Removal from Aqueous Solutions

UIDP/5006/2020. Publisher Copyright: © 2022 by the authors.CABs (Ca alginate beads), AVCABs (Aloe vera Ca alginate beads), and AVMNCABs (Aloe-vera functionalized magnetic nanoparticles entrapped Ca alginate beads) were developed as adsorbents for the removal of Cu(II) from aqueous solutions. The materials were characterized using Fourier-transform infrared (FTIR) spectroscopy, high-resolution scanning electron microscopic (HR-SEM) analysis, X-ray diffraction (XRD), energy-dispersive X-ray (EDX) spectroscopy, and a vibrating-sample magnetometer (VSM). The effect of several parameters, such as pH, time, temperature, adsorbent dose, etc., were investigated. The adsorption isotherm of Cu(II) was adjusted best to the Langmuir model. The maximum adsorption capacities were 111.11 mg/g, 41.66 mg/g, and 15.38 mg/g for AVMNCABs, AVCABs, and CABs, respectively. The study of the adsorption kinetics for Cu(II) ions on beads followed a pseudo-second-order kinetic model, with a very good correlation in all cases. The adsorption studies used a spectrophotometric method, dealing with the reaction of Cu(II) with KSCN and variamine blue.publishersversionpublishe

A concise synthesis of pyrazole clubbed imidazolone compounds as antimicrobial agents

We reported an efficient route for the synthesis of pyrazole clubbed imidazolone compounds. The products were characterized by standard techniques like IR,1H and 13C NMR, and LC-MS. They were investigated for their antimicrobial activity against several strains of bacteria (E. coli, P. aeruginosa, S. aureus and S. pyogenes) and fungi (C. albicans, A. niger,andA. clavatus) using broth dilution method. Compounds3j (-2-NO2),3r (-4-Br), and 3i (-2-OCH3) showed significant antimicrobial activity. 

A concise synthesis of pyrazole clubbed imidazolone compounds as antimicrobial agents

1738-1744We reported an efficient route for the synthesis of pyrazole clubbed imidazolone compounds. The products were characterized by standard techniques like IR,1H and 13C NMR, and LC-MS. They were investigated for their antimicrobial activity against several strains of bacteria (E. coli, P. aeruginosa, S. aureus and S. pyogenes) and fungi (C. albicans, A. niger,andA. clavatus) using broth dilution method. Compounds3j (-2-NO2),3r (-4-Br), and 3i (-2-OCH3) showed significant antimicrobial activity

DESIGN NOVEL SYNTHETIC ROOT OF BENZOXAZOLE DERIVATIVES AS IN VITRO ACTIVITIES: A RESEARCH ARTICLE

Being a hetero- cyclic moiety, benzoxazole finds application in much medicinal research as an initial reactant. Benzoxazole derivatives have unique significance in the field of medical research due to their incredible biological potential. During recent year Benzoxazole derivative showed interesting development in medicinal research. Many Novel benzoxazole derivatives (G3-G6) were formed by using 4- methyl 2-amiono phenol reagent with methanol, potassium hydroxide, carbon di- sulfide. We observed the process employing thin-layer chromatography and interpreted spectral analysis via NMR, LC-MS, IR Spectrometry and antibacterial activity done by MIC method with Escherichia Coli a gram negative bacteria, Staphylococcus aureus a gram positive bacteria and anti-tubercular activities done through alamar blue dye technique(ABD) using Mycobacterium Tuberculosis(MT) bacteria . Some tested derivatives showed potent activit

Synthesis, characterization, molecular docking studies and biological activity ofcoumarin linked 2-pyridone heterocycles

In the present paper, the synthesis, characterization, antimicrobial activity and in silico molecular docking study of6-((arylidene)amino)-4-(4-chlorophenyl)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o have been reported. Compounds 4d, 4g, 4j, 4k, 4m and 4o show significant activity. Structuredetermination of the synthesized compounds has been done by the standard spectroscopic techniques. It is observed thatbiological activity is influenced by electronic environment of the molecules. Electron withdrawing group at para positionplays a major role for enhancing the biological activity for antibacterial activity and the electron donating group at paraposition for antifungal activity. Compounds 4a-o have been further evaluated for cytotoxicity on HeLa cells. From thecytotoxicity results, compounds have been found to possess low cytotoxicity with potent antimicrobial activity

Synthesis, characterization, molecular docking studies and biological activity of coumarin linked 2-pyridone heterocycles

231-237In the present paper, the synthesis, characterization, antimicrobial activity and in silico molecular docking study of 6-((arylidene)amino)-4-(4-chlorophenyl)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o have been reported. Compounds 4d, 4g, 4j, 4k, 4m and 4o show significant activity. Structure determination of the synthesized compounds has been done by the standard spectroscopic techniques. It is observed that biological activity is influenced by electronic environment of the molecules. Electron withdrawing group at para position plays a major role for enhancing the biological activity for antibacterial activity and the electron donating group at para position for antifungal activity. Compounds 4a-o have been further evaluated for cytotoxicity on HeLa cells. From the cytotoxicity results, compounds have been found to possess low cytotoxicity with potent antimicrobial activity

Patterns of Care of Cancers and Radiotherapy in Ethiopia

PURPOSE: Radiotherapy (RT) is an essential component of cancer treatment. There is a lack of RT services in sub-Saharan Africa as well as limited knowledge regar