The influence of organochlorine compound exposure on the physiological development of children

The present study summarizes the advances on the knowledge of the health disturbances associated to fetal exposure to organochlorine compounds in a cohort of children from Menorca. Higher incidence of diverse deleterious health effects at 4 years of age have been observed, e.g. hexachlorobenzene (HCB) and poor social behavior and attention-deficit hyperactivity disorder, 4,4’-DDE and asthma, wheeze, lower respiratory tract infections and alteration of urinary coproporphyrins, HCB, ß-hexachlorocyclohexane and 4,4’-DDE and alteration of thyroid hormones, HCB, 4,4’-DDE and polychlorobiphenyls (PCBs) and overweight, 4,4’-DDT and PCBs and lower neurodevelopment. A protective effect of breastfeeding against decreases of cognitive skills in children due to 4,4’-DDT exposure has also been documented. This protective effect shows that other factors besides pollutant exposure and genetic variability influence on the health effects of environmental pollutants into human populations. These results are important for the understanding of the health implications of exposome studies.Aquest estudi resumeix els avenços en el coneixement dels trastorns de salut associats a l’exposició fetal a compostos organoclorats en una cohort de nens de Menorca. S’ha observat una incidència major de diversos efectes perjudicials per la salut als 4 anys d’edat, per exemple, hexaclorobenzè (HCB) i comportament social pobre i trastorn per dèficit d’atenció amb hiperactivitat, 4,4’- DDE i asma, xiulets pulmonars, infeccions de les vies respiratòries baixes i alteració de coproporfirines urinàries, HCB, ß-hexaclorociclohexà i 4,4’-DDE i alteració de les hormones tiroïdals, HCB, 4,4’-DDE i policlorobifenils (PCBs) i sobrepès, 4,4’-DDT i PCBs i menor desenvolupament neurològic. També s’ha documentat un efecte protector de la lactància materna contra la disminució de les habilitats cognitives dels nens a causa de l’exposició a 4,4’-DDT. Aquest efecte protector mostra que altres factors, a més de l’exposició a contaminants i genètica personal, influeixen en els efectes de salut dels contaminants ambientals en les poblacions humanes. Aquests resultats són importants per comprendre les implicacions per la salut dels estudis d’exposomes

Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4years of age

There are at present very few studies of the effects of polybromodiphenyl ethers (PBDEs), used as flame retardants in consumer products, on neurodevelopment or thyroid hormone levels in humans. The present study aims to examine the association between pre and postnatal PBDE concentrations and neurodevelopment and thyroid hormone levels in children at age 4. years and isolate the effects of PBDEs from those of PCBs, DDT, DDE and HCB.A prospective birth cohort in Menorca (Spain) enrolled 482 pregnant mothers between 1997 and 1998. At 4. years, children were assessed for motor and cognitive function (McCarthy Scales of Children's Abilities), attention-deficit, hyperactivity and impulsivity (ADHD-DSM-IV) and social competence (California Preschool Social Competence Scale). PBDE concentrations were measured in cord blood (N = 88) and in serum of 4. years olds (N = 244). Among all congeners analyzed only PBDE 47 was quantified in a reasonable number of samples (LOQ = 0.002. ng/ml). Exposure to PBDE 47 was analyzed as a dichotomous variable: concentrations above the LOQ (exposed) and concentrations below (referents).Scores for cognitive and motor functions were always lower in children pre and postnatally exposed to PBDE47 than in referents, but none of these associations was statistically significant (β coefficient (95%CI) of the total cognition score: -2.7 (-7.0, 1.6) for postnatal exposure, and -1.4 (-9.2, 6.5) for prenatal exposure). Postnatal exposure to PBDE 47 was statistically significantly related to an increased risk of symptoms on the attention deficit subscale of ADHD symptoms (RR (95%CI) = 1.8 (1.0, 3.2)) but not to hyperactivity symptoms. A statistically significant higher risk of poor social competence symptoms was observed as a consequence of postnatal PBDE 47 exposure (RR (95%CI) = 2.6 (1.2, 5.9)). Adjustment for other organochlorine compounds did not influence the results. Levels of thyroid hormones were not associated to PBDE exposure.This study highlights the importance of assessing the effects of PBDE exposure not just prenatally but also during the early years of life. In the light of current evidence a precautionary approach towards PBDE exposure of both mothers and children seems warranted. © 2010 Elsevier Ltd

Dynamic capabilities and innovation: a Multiple-Case Study

After a detailed survey of the scientific literature, it was found that several characteristics of dynamic capabilities were similar to those of innovation capability. Therefore, with a deeper study of the first ones, it could be possible to design a model aimed to structure innovation capability. Thus, this work presents a conceptual model, where the innovation capability is shown as result of three processes: knowledge absorption and creation capability, knowledge integration and knowledge reconfiguration. Furthermore, taking into account that dynamic capabilities are underpinned on actors, physical resources, structures and systems, and organizational culture, the model uses variables that integrate each one of these four subconstructos in order to facilitate the measurement of innovation capability in future researches. Moreover, the model separates knowledge exploitation and exploration activities. Applying this model, firms will be able of structuring and identifying the more important activities in the process of continuous innovation. Finally, model validation is done by means of an exploratory multiple-case study, which is applied on three technology-based companies of the audiovisual sector

Good practices to develop innovation capability: two case studies in the broadcasting sector

The main objective of this research is to contribute to innovation capability understanding. Furthermore, it is mainly focused in the way innovation capability is built and developed. Based on a multiple case study and interviews with managers, who are responsible for the new product development projects, in two innovative technology- based companies (ITBC) in the broadcasting sector, a collection of practices are identified and classified in four dimensions: 1) Innovation strategy, 2) Human capital development, 3) Organizational structure, and 4) Organizational culture. The case analysis revealed that a collection of practices that promote successful results in the new product development projects are critical both to improve and to build innovation capabilityPeer ReviewedPreprintPresentat al XX Congreso Nacional ACEDE,Granada, 201

Good practices of innovation: an exploratory case study in the broadcasting sector

The main objective of this research is to contribute to innovation capability understanding. Furthermore, it is mainly focused in the way innovation capability is built and developed. Based on a multiple case study and interviews with managers, who are responsible for the new product development projects, in two innovative technology- based companies (ITBC) in the broadcasting sector, a collection of practices are identified and classified in four dimensions: 1) Innovation strategy, 2) Human capital development, 3) Organizational structure, and 4) Organizational culture. The case analysis revealed that a collection of practices that promote successful results in the new product development projects are critical both to improve and to build innovation capabilityPostprint (published version

Organochlorine in the serum of inhabitants living near an electrochemical factory

7 pages, 2 figures, 3 tables.-- PMID: 10448322 [PubMed].-- PMCID: PMC1757711.OBJECTIVES: To measure the impact of occupational and lifestyle factors on concentrations of organochlorine compounds in a general population sample living near an electrochemical factory with a high airborne concentration of hexachlorobenzene (HCB).METHODS: Serum samples from 608 people (328 selected from a random sample) were collected in 1994. Information on lifestyles, occupation, and medical condition was obtained by questionnaire.RESULTS: HCB and polychlorinated biphenyls (PCBs) were detected in all samples (means 36.7 ng/ml and 4.3 ng/ml respectively), followed by dichlorodiphenyl dichloroethane (DDE) and beta-hexachlorocyclohexane (beta-HCH), found in 98.7% and 87.3% of the samples respectively (means 4.6 ng/ml and 2.5 ng/ml, respectively). Concentrations of HCB were the highest ever reported. Occupation in the factory was the main determinant of the variation in concentrations of HCB (regression coefficients 1.52 (SEM 0.14) in 1n (HCB) for workers in the production department, and 2.13 (0.23) for workers in maintenance department) and explained the highest concentrations of HCB found in men of middle age. In retired workers, concentrations of HCB declined with time since retirement. The PCBs, dichlorodiphenyl trichloroethane (DDT), and beta-HCH were independent of the occupation and concentrations were similar to those found in other populations. Concentrations of beta-HCH and DDE in the whole population, and HCB among non-workers, were higher in women than in men. Concentrations of all measured organochlorine compounds increased with age and body mass index. Consumption of locally caught fish was an independent determinant of HCB and PCB concentrations.CONCLUSIONS: This population incorporated HCB directly through occupation in the electrochemical factory, by airborne pollution, and consumption of locally caught fish. Concentrations of other common organochlorine compounds were not higher than expected. Environmental exposures to these compounds deserve attention due to their persistence and potential health effects.This work was supported by a grant from the “Fondo de Investigación Sanitaria”, Spain (FIS 93/0006-01).Peer reviewe