IT GOVERNANCE AUDIT AT PT PERUSAHAAN GAS NEGARA USING COBIT FRAMEWORK

The use of information and communication technology in a company gives an important contribution for the achievement of business objectives. PT Perusahaan Gas Negara, especially in the Business Solutions and Services Operations (BSSO), plays a significant role in the utilization of information and communication technology assets to PT Perusahaan Gas Negara. It takes a good IT governance for BSSO to improve the efficiency and effectiveness of IT usage. Audit of IT governance maturity using COBIT 4.1. Maturity model level used to determine the maturity level of IT usage in the enterprise with a scale of 0 (non-existent) to 5 (optimized). This study focused on two domains namely Plan and Organise (PO) and Monitor and Evaluate (ME) model to measure the maturity level of IT maturity levels in PT Perusahaan Gas Negara. From this study, the results of the maturity level domain PO is 3.13 and ME is 2.98, it can be given the conclusion that the maturity level of IT governance at PT PGN is in level 3 (defined). At this level means that all the procedures in the company are standardized and documented, but the company is still not able to detect the deviations that have occurred

Endoplasmic reticulum stress and apoptosis induced by manganese trigger α-synuclein accumulation

Purpose: To explore whether α-synuclein aggregation is linked to endoplasmic reticulum (ER) stress and apoptosis induced by manganese (Mn) on CATH.a dopaminergic cell lines.Methods: Western blot analysis for the expression of 78 kDa glucose-regulated protein (GRP78), phosphorylated eukaryotic initiation factor 2α (p-eIF-2α), eIF2α, inositol requiring enzyme 1(IRE-1α), cleaved caspase-3, and C/EBP homologous protein (CHOP) was performed, including overexpression of recombinant adenovirus-mediated α-synuclein on CATH.a dopaminergic cell line.Results: It was observed that cell viability (p < 0.05) was significantly reduced by 250 μM exposed for 3h and 1,000 μM of MnCl2 exposed for 24 h. The expression of p-elF-2α, IRE-1α, and GRP78 was especially induced by 1,000 μM of MnCl2 exposed at 3, 6, and 12 h, respectively (p < 0.05). Twenty four-hour exposure of 250 uM of MnCl2 and the 3 h exposure of 1,000 uM of MnCl2 significantly induced CHOP, active caspase 3 and α-synuclein expression (p < 0.05). α-Synuclein combined with recombinant adenoviral transduction increased GRP78, IRE-1α and eIF2a, CHOP and caspase 3 expression at longer times and at higher concentrations of manganese exposure on CATH.a dopaminergic cells.Conclusion: Based on these findings, Mn is a risk factor for diseases associated with α-synuclein accumulation. Furthermore, α-synuclein accumulation is associated with apoptosis via ER stress induced by Mn.Keywords: Manganese (Mn), α- Synuclein, Endoplasmic reticulum (ER) stress, Apoptosi

ANALISIS PERBANDINGAN SEMANTIK DALAM SISTEM PENCARIAN DAN REKOMENDARI PADA TIGA JEJARING SOSIAL (FACEBOOK, TWITTER DAN LINKEDIN)

Pengguna jejaring sosial saat ini sudah melingkupi semua umur, baik generasimuda ataupun orang dewasa. Jenis-jenis penggunaan jejaring sosial pun sudahmulai beragam, seperti digunakan untuk berbagi foto, untuk bisnis, pencarianjodoh, atau sekedar menambah pertemanan. Fitur yang sangat melekat dalamjejaring sosial adalah fitur pencarian dan pemberian rekomendasi mengenaihal-hal yang berhubungan dengan bagian dari profil pengguna, sepertimisalnya kesamaan dalam lingkup institusi pendidikan, daerah dan letakgeografis. Pada paper ini kami akan membandingkan metode semantik yangdigunakan dalam fitur pencarian dan rekomendasi pada beberapa situs jejaringsosial dalam fitur tersebut karena metode semantik yang digunakan setiapjejaring sosial berbeda. Tujuan akhir dari pembuatan paper ini adalahmenemukan jejaring sosial dengan tingkat keefektivitasan algoritma semantikyang paling tinggi dan paling efisien

A Method for Studying the Effect of Pressure on the Viscosity of Polymer Solutions

90 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1960.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

Prévalence de patients âgés nés à l'étranger, hospitalisés au centre hospitalier Emile Roux et description des pathologies et de l'aspect social et ethnique

L'étude a été menée au Centre Hospitalier Emile Roux de Limeil-Brévannes, dans la région parisienne, en 2003. L'objectif était de calculer la prévalence de patients âgés, nés à l'étranger, hospitalisés en soins de suite et d'aiguë, en gériatrie, ainsi que d'estimer l'épidémiologie et de décrire les différentes pathologies et aussi description de certains aspects sociaux et ethniques. Cette population (12% de nos aînés de plus de 60 ans en métropole) est hétérogène, née dans différents pays et ethnies se compose essentiellement d'immigrés et de rapatriés des colonies. Ils viennent des deux zones géographiques majoritaires, Espagne-Italie-Portugal et Algérie-Maroc-Tunisie, et ils ont une culture non française et étaient majoritairement ouvriers ou femmes au foyer. La prévalence est à 12,16% de toutes les entrées pendant la période de l'étude. La démence a un taux à 39%, le diabète de type 2 est très fréquent à 34%, l'AVC à 30,5% et surtout la dépression est à 64,4%. Nous avons travaillé sur certains critères de l'ethnicité (loin des notions de " race ", de nationalité ou d'immigré) afin d'éviter toute interprétation péjorative. La revue de la littérature nous donne des éclaircissements intéressants, surtout issus des publications anglo-saxonnes. Nos résultats peuvent permettre la connaissance des particularités de cette population et ouvrir la voie à des projets de recherche, afin de donner des outils adéquats aux professionnels de santéThe study was undertaken in the Emile Roux Hospital of Limeil-Brévannes, in the Paris area, in 2003. The objective was to calculate the prevalence of elderly patients, born abroad, hospitalized in rehabilitation and acute geriatric units, to estimate epidemiology, to describe various pathologies and also certain social and ethnic aspects. This population (12% of French elderly of more than 60 years old) is heterogeneous, born in various countries and ethnic groups, is composed primarily of immigrants and repatriates from the colonies. They come from the two geographical areas, Spain-Italy-Portugal and Algeria-Morocco-Tunisia and they have a different culture and were mainly manual workers or housewives. The prevalence was 12,16 % of the overall admissions during the period of the study. Dementia rate was 39%, type 2 diabetes was very frequent, up to 34%, stroke 30,5 % and especially depression 64,4 %. We used certain ethnicity criteria (beyond the concepts of race , nationality or immigrant) in order to avoid any pejorative interpretation. The review of the literature gives us interesting explanations, especially resulting from the Anglo-Saxon publications. Our results may allow us to be aware of the characteristics of this population and open the way to more research projects of ethnic minorities, in order to give adequate tools to health caregiversPARIS12-CRETEIL BU Médecine (940282101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF