Predicting Delivery Time of Components in a Supply Chain

Generally, the present disclosure is directed to predicting a delivery time of components in a supply chain. In particular, in some implementations, the systems and methods of the present disclosure can include or otherwise leverage one or more machine-learned models to predict a delivery time of a component based on enterprise data relating to the component

Direct composite veneers - restoring esthetics by procuring patient demand: a case report

Re-establishing a patient’s lost dental esthetic appearance is one of the most important topics for contemporary dentistry. New treatment materials and methods have been coming on the scene, day by day, in order to achieve such an aim. Most dentists prefer more conservative and aesthetic approaches, such as direct and indirect laminate veneer restorations, instead of full-ceramic crowns for anteriors where aesthetics is really important. Laminate veneers are restorations which are envisioned to correct existing abnormalities, esthetic deficiencies and discolorations. Laminate veneer restorations may be processed in two different ways: direct or indirect. Direct laminate veneers have no need to be prepared in the laboratory and are based on the principle of application of a composite material directly to the prepared tooth surface in the dental clinic. Indirect laminate veneers may be produced from composite materials or ceramics, which are cemented to the tooth with an adhesive resin. In this case report, direct composite laminate veneer technique used for patients with esthetic problems is described and six-month follow-up are discussed. As a conclusion, direct laminate veneer restorations may be a treatment option for patients with the esthetic problems of anterior teeth in case similar to those reported here

A Quantitative Approach to Prioritize Sustainable Concrete

Cement industry consumes high energy and produces major emissions to the environment. In order to reduce the effects (environmental impact, energy, and resources) caused by conventional materials, various by-products and pozzolonic material are used to achieve sustainable concrete. Assessing the concrete performance based on multiple conflicting attributes is decisive and compelling. It is difficult to choose an alternative among the Supplementary Cementitious Materials (SCM) considering a set of quantitative performance attributes. Hence, the present study utilizes the theories of decision making to prioritize an alternative environmentally and technologically. The purpose of the present study is to observe the sustainable performance of five different concretes made of OPC, Fly ash, GGBS, Metakaolin and Composite Cement for a particular grade of concrete. The study has considered workability, strength attribute (compressive strength, split tensile and flexural strength) and durability attribute (Sorptivity and RCPT) at their respective optimum replacements. To prioritize an alternative material considering quantitative attributes, Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) is utilized. From the results, it is observed that considering all attributes, flyash based concrete has higher performance and is prioritized among others. The developed approach facilitates the decision-makers in the selection of a sustainable alternative

DESIGN AND FABRICATION OF MEDICATED CHOCOLATE FORMULATION BY CHOCOLATE DRUG DELIVERY SYSTEM

Objective: The objective of this study is to design and fabricate Chlorpheniramine Maleate chocolate formulation by chocolate drug delivery system. Chlorpheniramine Maleate binds to histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of negative symptoms brought on by histamine.Methods: Chocolate is a range of products derived from cocoa (cacao), mixed with fat (i.e., cocoa butter) and finely powdered sugar to produce a solid confectionery. The medicated chocolate formulation is widely used for pediatric administration and increases patient compliance. Chlorpheniramine Maleate chocolate formulation is prepared to improve patient compliance. Chocolates were formulated (F1-F3) with a total fat of 25-35 % (w/w) from cocoa liquor and cocoa butter with more than 34% total cocoa, composition as specified for dark chocolate, lecithin, sweetening agents.Results: The prepared chocolate formulations were evaluated for general appearance, drug content, In vitro drug release and DSC and FTIR, moisture content and blooming tests. F1 formulation releases complete drug within 60 min.Conclusion: The results indicate that the formulation has no drug excipient interactions and there was no degradation in drug, it is stable during chocolate formulation preparation.Â

Development of floating matrix tablets of Ofloxacin and Ornidazole in combined dosage form: in vitro and in vivo evaluation in healthy human volunteers

Ofloxacin (OFX) is a synthetic broad spectrum analog of second generation fluoroquinolone antibiotic. It is used for the treatment of urinary tract, prostate, skin, urinary and respiratory tract infections. Ornidazole (ORN) is a nitroimidazole derivative. It is used in the treatment of bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis and infections due to anaerobic bacteria. These drugs are highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence we attempted to develop a gastro retentive floating matrix type drug delivery system for Ofloxacin and Ornidazole in combined dosage form with hydroxyl propyl methyl cellulose (HPMC) K15M, HPMC K100M and polyethylene oxide 18NF (PEO). The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy and differential scanning calorimetry. The results suggested no physicochemical incompatibility between the drug and the polymers. The prepared floating drug delivery systems were evaluated for physicochemical characteristics, mainly in vitro release and in vivo residence time by radiographic studies. The best formulation (F2) was selected based on in vitro release and physicochemical characteristics and used in vivo radiographic studies by incorporating BaSO4. These studies revealed that tablets 300 ± 30 minutes in healthy human volunteers in fasting state and indicated that the gastric retention was increased by floating principle. By fitting the data into zero order, first order and Higuchi models, it was concluded that drug release from matrix tablets followed Higuchi model and the mechanism of drug release was diffusion mediated. Based on the physical evaluation, in vitro drug release and in vivo characteristics, it was concluded that for potential therapeutic use, suitable for the development of a floating drug delivery system of Ofloxacin and Ornidazole in combined dosage form

Image Information Retrieval based on Edge Responses, Shape and Texture Features using Datamining Techniques

The present paper proposes a new technique that extracts significant structural, texture and local edge features from images. The local features are extracted by a steady local edge response that can sustain the presence of noise, illumination changes. The local edge response image is converted in to a ternary pattern image based on a local threshold. The structural features are derived by extracting shapes in the form of textons. The texture features are derived by constructing grey level co-occurrence matrix (GLCM) on the derived texton image. A new variant of K-means clustering scheme is proposed for clustering of images. The proposed method is compared with various methods of image retrieval based on data mining techniques. The experimental results on Wang dataset shows the efficacy of the proposed method over the other methods

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF DEXMETHYLPHENIDATE AND SERDEXMETHYLPHENIDATE BY USING RP-HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORM

Objective: The current investigation was pointed at developing and progressively validating novel, simple, responsive and stable RP-HPLC method for the simultaneous measurement of active pharmaceutical ingredients of Dexmethylphenidate and Serdexmethylphenidate. Methods: A simple, selective, validated and well-defined stability that shows isocratic RP-HPLC methodology for the simultaneous determination of Dexmethylphenidate and Serdexmethylphenidate. The chromatographic strategy utilized inertsil ODS column of dimensions 250x4.6 mm, 5 µ, using isocratic elution with a mobile phase of acetonitrile and 0.1% orthophosphoric acid (70:30). A flow rate of 1 ml/min and a detector wavelength of 262 nm utilizing the PDA detector were given in the instrumental settings. Recovery, specificity, linearity, accuracy, robustness, ruggedness were determined as a part of method validation and the results were found to be within the acceptable range. Validation of the proposed method was carried out according to an international conference on harmonization (ICH) guidelines. Results: LOD and LOQ for the active ingredient were established with respect to test concentration. The calibration chart plotted was linear with a regression coefficient of R2>0.999, which means the linearity was within the limit. Conclusion: The proposed method to be fast, simple, feasible and affordable in assay condition. During stability tests, it can be used for routine analysis of production samples and to verify the quality of drug samples during stability studies

Image Compression Techniques by using Wavelet Transform

This paper is concerned with a certain type of compression techniques by using wavelet transforms. Wavelets are used to characterize a complex pattern as a series of simple patterns and coefficients that, when multiplied and summed, reproduce the original pattern.  The data compression schemes can be divided into lossless and lossy compression. Lossy compression generally provides much higher compression than lossless compression. Wavelets are a class of functions used to localize a given signal in both space and scaling domains. A MinImage was originally created to test one type of wavelet and the additional functionality was added to Image to support other wavelet types, and the EZW coding algorithm was implemented to achieve better compression. Keywords: Wavelet Transforms, Image Compression, Lossless Compression, Lossy Compressio

Genotypic, phenotypic variability and evaluation of okra [Abelmoschus esculentus (L.) Moench] genotypes for yield components

Okra [Abelmoschus esculentus (L.) Moench] is India's major vegetable crop, accounting for 60% of exports. Comparatively, Tamil Nadu has a small area of cultivation and production. Hence, the present study involves the utilizatization of simple measure of variability and genetic variance to develop new varieties. The experiment was conducted with 60 genotypes of okra crop using 20 quantitative traits. The analysis of variance found that genotypes were significant (P 0.05 and P 0.01) for all of the traits tested. The fruit yield plant-1 ranged from 176.40 to 438.40 g, with 347.42 g being the average. In all the traits studied, the phenotypic coefficient of variation (PCV) was higher than genotypic coefficient of variation (GCV). The closeness of PCV and GCV values suggested that the environment had little influence on manifestation of the characters under examination. GCV (1.89-13.98) and PCV (4.06-16.61) levels were found to be moderate (10-20) and low (<10), respectively, in the study. Heritability ranged from 21.73 (days to first fruit harvest) to 97.19 (plant height) percent. At 5% selection intensity, the genetic advance (GA)% mean ranged from 1.82 (days to first fruit harvest) to 27.38 (plant height). Plant height (13.68, 13.48), internodal length (16.61, 13.98), first fruiting node (13.00, 10.89), number of fruits plant-1 (13.19, 11.91), number of marketable fruits plant-1 (13.36, 11.97) and fruit yield plant-1 (13.75, 12.29) showed high heritability and high GA% mean. Thus, the above-mentioned characteristics are additive genetic control and direct selection in okra has good potential for improvement in fruit yield

Ecological Studies of Cestode Parasites of Some Marine Fishes along the Raigad coast (M.S) India

     This communication deals with ecological studies of cestode parasites of some marine fishes along the Raigad coast (M.S) India, over a period of one year (June to December 2006 and January to May 2007). The study highlights at establishing the magnitude of parasitization in different fishes as well as quantifying the host specificity of the parasites and their fish hosts. Fish samples were collected from main landing beaches of Raigad coast: Alibag, Borli, Murud, Dighi and Shrivardhan. The fish sample (Host) examined for parasites included: Rastrelliger kanagurata, Dasyatis bleekeri, Dasyatis walga, Aetomylaeus nichoffii, Chiloscyllium palgiosum, Mobula mobular, Carcharihinus dussumeri and Rhynchobatus djeddensis. This study has revealed that out of 8 fishes examined only 5 species were infected with parasites. Dasyatis bleekari infected with Acanthobothrium and Rhinebothrium; Dasyatis walga infected with Tetragonacephalum and Nybelina: Aetomylaeus nichoffii infected with Hexacanalis and Tylocephalum; Chiloscyllium plagiosum infected with Phyllobothrium: Rhynchobatus djeddensis infected with Tetragonacephalum, out of the 5 species Dasyatis bleekari was the most heavily infected increase with age (size) especially in Aetomylaeus nichoffii where very young fish were rarely infected where as     adult  were heavily infected