TT‾T\overline{T} Deformation of N=(1,1)\mathcal{N}=(1,1) Off-Shell Supersymmetry and Partially Broken Supersymmetry

We construct the superaction for the $T\overline{T}$ deformation of 2D free $\mathcal{N}=(1,1)$ supersymmetric model with a deformed superfield. We show that the $\mathcal{N}=(1,1)$ off-shell is deformed under the $T\overline{T}$ deformation, which is reflected by the deformed superfield. We interpret this superaction as an effective action of the Goldstone superfield for the partial spontaneous breaking of $\mathcal{N}=(2,2)$ supersymmetry to $\mathcal{N}=(1,1)$. We demonstrate that the unbroken and broken supersymmetry of the effective superaction corresponds to the off-shell $\mathcal{N}=(1,1)$ supersymmetry and the off-shell fermi global non-linear symmetry in the $T\overline{T}$-deformed theory, respectively. We show that this effective superaction can be obtained by the non-linear realization of the partially broken global supersymmetry (PBGS) from the coset superspace. Furthermore, we reproduce the superaction by the constrained superfield method accompanied by a field redefinition.Comment: 33 pages; v2: reference adde

Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers

Image-Object-Specific Prompt Learning for Few-Shot Class-Incremental Learning

While many FSCIL studies have been undertaken, achieving satisfactory performance, especially during incremental sessions, has remained challenging. One prominent challenge is that the encoder, trained with an ample base session training set, often underperforms in incremental sessions. In this study, we introduce a novel training framework for FSCIL, capitalizing on the generalizability of the Contrastive Language-Image Pre-training (CLIP) model to unseen classes. We achieve this by formulating image-object-specific (IOS) classifiers for the input images. Here, an IOS classifier refers to one that targets specific attributes (like wings or wheels) of class objects rather than the image's background. To create these IOS classifiers, we encode a bias prompt into the classifiers using our specially designed module, which harnesses key-prompt pairs to pinpoint the IOS features of classes in each session. From an FSCIL standpoint, our framework is structured to retain previous knowledge and swiftly adapt to new sessions without forgetting or overfitting. This considers the updatability of modules in each session and some tricks empirically found for fast convergence. Our approach consistently demonstrates superior performance compared to state-of-the-art methods across the miniImageNet, CIFAR100, and CUB200 datasets. Further, we provide additional experiments to validate our learned model's ability to achieve IOS classifiers. We also conduct ablation studies to analyze the impact of each module within the architecture.Comment: 8 pages, 4 figures, 4 table

Green Tea Consumption and Stomach Cancer Risk: A Meta-Analysis

OBJECTIVES: Green tea has been suggested to have a chemopreventive effect against various cancers including stomach cancer. The aim of this study is to elucidate the relationship between green tea consumption and stomach cancer risk by meta-analysis. METHODS: Eighteen observational studies were identified using MEDLINE, THE COCHRANE LIBRARY, RISS, and a manual search. Summary relative risks/odds ratios (RR/ORs) for the highest versus non/lowest green tea consumption levels were calculated on the basis of fixed and random effect models. Subgroup analyses were used to examine heterogeneity across the studies. RESULTS: The combined results indicate a reduced risk of stomach cancer with intake of green tea (RR/OR=0.86, 95% CI=0.74-1.00). Subgroup analysis with six studies that reported differences between the highest and lowest consumption levels equal to or greater than five cups/day revealed a statistically significant protective effect (RR/OR=0.68, 95% CI=0.53-0.87). CONCLUSION: Green tea appears to play a protective role against the development of stomach cancer. The results also suggest that a higher level of green tea consumption might be needed for a clear preventive effect to appear. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis.ope

Structural abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS)

AbstractPurposeThe aim of this study was to investigate cortical thickness and gray matter volume abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS). We additionally assessed the effects of comorbid attention-deficit/hyperactivity (ADHD) on these abnormalities.MethodsSurface and volumetric MR imaging data of children with newly diagnosed BCECTS (n=20, 14 males) and age-matched healthy controls (n=20) were analyzed using FreeSurfer (version 5.3.0, https://surfer.nmr.mgh.harvard.edu). An additional comparison was performed between BCECTS children with and without ADHD (each, n=8). A group comparison was carried out using an analysis of covariance with a value of significance set as p<0.01 or p<0.05.ResultsChildren with BCECTS had significantly thicker right superior frontal, superior temporal, middle temporal, and left pars triangularis cortices. Voxel-based morphometric analysis revealed significantly larger cortical gray matter volumes of the right precuneus, left orbitofrontal, pars orbitalis, precentral gyri, and bilateral putamen and the amygdala of children with BCECTS compared to healthy controls. BCECTS patients with ADHD had significantly thicker left caudal anterior and posterior cingulate gyri and a significantly larger left pars opercularis gyral volume compared to BCECTS patients without ADHD.ConclusionChildren with BCECTS have thicker or larger gray matters in the corticostriatal circuitry at the onset of epilepsy. Comorbid ADHD is also associated with structural aberrations. These findings suggest structural disruptions of the brain network are associated with specific developmental electro-clinical syndromes

A single gene of a commensal microbe affects host susceptibility to enteric infection

Indigenous microbes inside the host intestine maintain a complex self-regulating community. The mechanisms by which gut microbes interact with intestinal pathogens remain largely unknown. Here we identify a commensal Escherichia coli strain whose expansion predisposes mice to infection by Vibrio cholerae, a human pathogen. We refer to this strain as 'atypical' E. coli (atEc) because of its inability to ferment lactose. The atEc strain is resistant to reactive oxygen species (ROS) and proliferates extensively in antibiotic-treated adult mice. V. cholerae infection is more severe in neonatal mice transplanted with atEc compared with those transplanted with a typical E. coli strain. Intestinal ROS levels are decreased in atEc-transplanted mice, favouring proliferation of ROS-sensitive V. cholerae. An atEc mutant defective in ROS degradation fails to facilitate V. cholerae infection when transplanted, suggesting that host infection susceptibility can be regulated by a single gene product of one particular commensal species.

Red Ginseng Extract Facilitates the Early Differentiation of Human Embryonic Stem Cells into Mesendoderm Lineage

Human embryonic stem cells (hESCs) have capacities to self-renew and differentiate into all cell types in vitro. Red ginseng (RG) is known to have a wide range of pharmacological effects in vivo; however, the reports on its effects on hESCs are few. In this paper, we tried to demonstrate the effects of RG on the proliferation and differentiation of hESCs. Undifferentiated hESCs, embryoid bodies (EBs), and hESC-derived cardiac progenitors (CPs) were treated with RG extract at 0.125, 0.25, and 0.5 mg/mL. After treatment of undifferentiated hESCs from day 2 to day 6 of culture, BrdU labeling showed that RG treatment increased the proliferation of hESCs, and the expression of Oct4 and Nanog was increased in RG-treated group. To find out the effects of RG on early differentiation stage cells, EBs were treated with RG extract for 10 days and attached for further differentiation. Immunostaining for three germ layer markers showed that RG treatment increased the expressions of Brachyury and HNF3β on EBs. Also, RG treatment increased the expression of Brachyury in early-stage and of Nkx2.5 in late-stage hESC-derived CPs. These results demonstrate facilitating effects of RG extract on the proliferation and early differentiation of hESC