10,425 research outputs found
A Reliability-Aware Approach for Resource Efficient Virtual Network Function Deployment
OAPA Network function virtualization (NFV) is a promising technique aimed at reducing capital expenditures (CAPEX) and operating expenditures (OPEX), and improving the flexibility and scalability of an entire network. In contrast to traditional dispatching, NFV can separate network functions from proprietary infrastructure and gather these functions into a resource pool that can efficiently modify and adjust service function chains (SFCs). However, this emerging technique has some challenges. A major problem is reliability, which involves ensuring the availability of deployed SFCs, namely, the probability of successfully chaining a series of virtual network functions (VNFs) while considering both the feasibility and the specific requirements of clients, because the substrate network remains vulnerable to earthquakes, floods and other natural disasters. Based on the premise of users & #x2019; demands for SFC requirements, we present an Ensure Reliability Cost Saving (ER & #x005F;CS) algorithm to reduce the CAPEX and OPEX of telecommunication service providers (TSPs) by reducing the reliability of the SFC deployments. The results of extensive experiments indicate that the proposed algorithms perform efficiently in terms of the blocking ratio, resource consumption, time consumption and the first block
Key nodes of a microRNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer
Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition (EMT), during which cells dedifferentiate from a relatively rigid cell structure/morphology to a flexible and changeable structure/morphology often associated with mesenchymal cells. The presence of EMT in human epithelial tumors is reflected by the increased expression of genes and levels of proteins that are preferentially present in mesenchymal cells. The combined presence of these genes forms the basis of mesenchymal gene signatures, which are the foundation for classifying a mesenchymal subtype of tumors. Indeed, tumor classification schemes that use clustering analysis of large genomic characterizations, like The Cancer Genome Atlas (TCGA), have defined mesenchymal subtype in a number of cancer types, such as high-grade serous ovarian cancer and glioblastoma. However, recent analyses have shown that gene expression-based classifications of mesenchymal subtypes often do not associate with poor survival. This “paradox” can be ameliorated using integrated analysis that combines multiple data types. We recently found that integrating mRNA and microRNA (miRNA) data revealed an integrated mesenchymal subtype that is consistently associated with poor survival in multiple cohorts of patients with serous ovarian cancer. This network consists of 8 major miRNAs and 214 mRNAs. Among the 8 miRNAs, 4 are known to be regulators of EMT. This review provides a summary of these 8 miRNAs, which were associated with the integrated mesenchymal subtype of serous ovarian cancer
Investigation of the behaviour of electronic resistive switching memory based on MoSe<font size=-1><sub>2</sub></font>-doped ultralong Se microwires
published_or_final_versio
SHRIMP zircon geochronology of the Emeishan Large Igneous Province (SW China): implications for double mass extinctions in Late Permian
Abstract in http://www.lpi.usra.edu/meetings/gold2001/pdf/3519.pd
Fingerprint Recognition with Identical Twin Fingerprints
Fingerprint recognition with identical twins is a challenging task due to the closest genetics-based relationship existing in the identical twins. Several pioneers have analyzed the similarity between twins' fingerprints. In this work we continue to investigate the topic of the similarity of identical twin fingerprints. Our study was tested based on a large identical twin fingerprint database that contains 83 twin pairs, 4 fingers per individual and six impressions per finger: 3984 (83*2*4*6) images. Compared to the previous work, our contributions are summarized as follows: (1) Two state-of-the-art fingerprint identification methods: P071 and VeriFinger 6.1 were used, rather than one fingerprint identification method in previous studies. (2) Six impressions per finger were captured, rather than just one impression, which makes the genuine distribution of matching scores more realistic. (3) A larger sample (83 pairs) was collected. (4) A novel statistical analysis, which aims at showing the probability distribution of the fingerprint types for the corresponding fingers of identical twins which have same fingerprint type, has been conducted. (5) A novel analysis, which aims at showing which finger from identical twins has higher probability of having same fingerprint type, has been conducted. Our results showed that: (a) A state-of-the-art automatic fingerprint verification system can distinguish identical twins without drastic degradation in performance. (b) The chance that the fingerprints have the same type from identical twins is 0.7440, comparing to 0.3215 from non-identical twins. (c) For the corresponding fingers of identical twins which have same fingerprint type, the probability distribution of five major fingerprint types is similar to the probability distribution for all the fingers' fingerprint type. (d) For each of four fingers of identical twins, the probability of having same fingerprint type is similar
Robotic ubiquitous cognitive ecology for smart homes
Robotic ecologies are networks of heterogeneous robotic devices pervasively embedded in everyday environments, where they cooperate to perform complex tasks. While their potential makes them increasingly popular, one fundamental problem is how to make them both autonomous and adaptive, so as to reduce the amount of preparation, pre-programming and human supervision that they require in real world applications. The project RUBICON develops learning solutions which yield cheaper, adaptive and efficient coordination of robotic ecologies. The approach we pursue builds upon a unique combination of methods from cognitive robotics, machine learning, planning and agent- based control, and wireless sensor networks. This paper illustrates the innovations advanced by RUBICON in each of these fronts before describing how the resulting techniques have been integrated and applied to a smart home scenario. The resulting system is able to provide useful services and pro-actively assist the users in their activities. RUBICON learns through an incremental and progressive approach driven by the feed- back received from its own activities and from the user, while also self-organizing the manner in which it uses available sensors, actuators and other functional components in the process. This paper summarises some of the lessons learned by adopting such an approach and outlines promising directions for future work
Colossal magnetocapacitance and scale-invariant dielectric response in phase-separated manganites
Thin films of strongly-correlated electron materials (SCEM) are often grown
epitaxially on planar substrates and typically have anisotropic properties that
are usually not captured by edge-mounted four-terminal electrical measurements,
which are primarily sensitive to in-plane conduction paths. Accordingly, the
correlated interactions in the out-of-plane (perpendicular) direction cannot be
measured but only inferred. We address this shortcoming and show here an
experimental technique in which the SCEM under study, in our case a 600
Angstrom-thick (La1-yPry)0.67Ca0.33MnO3 (LPCMO) film, serves as the base
electrode in a metal-insulator-metal (MIM) trilayer capacitor structure. This
unconventional arrangement allows for simultaneous determination of colossal
magnetoresistance (CMR) associated with dc transport parallel to the film
substrate and colossal magnetocapacitance (CMC) associated with ac transport in
the perpendicular direction. We distinguish two distinct strain-related
direction-dependent insulator-metal (IM) transitions and use Cole-Cole plots to
establish a heretofore unobserved collapse of the dielectric response onto a
universal scale-invariant power-law dependence over a large range of frequency,
temperature and magnetic field.Comment: 32 pages, 4 figures, Supplementary section included, Submitted to
Nature Physic
Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes
BACKGROUND: Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three recognised forms of mammalian thioredoxin reductase designated as TR1, TR3 and TGR, that represent the cytosolic, mitochondrial and novel forms respectively. In this study we elucidated the genomic organisation of the mouse (Txnrd1) and human thioredoxin reductase 1 genes (TXNRD1) through library screening, restriction mapping and database mining. RESULTS: The human TXNRD1 gene spans 100 kb of genomic DNA organised into 16 exons and the mouse Txnrd1 gene has a similar exon/intron arrangement. We also analysed the alternative splicing patterns displayed by the mouse and human thioredoxin reductase 1 genes and mapped the different mRNA isoforms with respect to genomic organisation. These isoforms differ at the 5' end and encode putative proteins of different molecular mass. Genomic DNA sequences upstream of mouse exon 1 were compared to the human promoter to identify conserved elements. CONCLUSIONS: The human and mouse thioredoxin reductase 1 gene organisation is highly conserved and both genes exhibit alternative splicing at the 5' end. The mouse and human promoters share some conserved sequences
Investigation of energy storage batteries in stability enforcement of low inertia active distribution network
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