Enhancing Cyber-Resiliency of DER-based SmartGrid: A Survey

The rapid development of information and communications technology has enabled the use of digital-controlled and software-driven distributed energy resources (DERs) to improve the flexibility and efficiency of power supply, and support grid operations. However, this evolution also exposes geographically-dispersed DERs to cyber threats, including hardware and software vulnerabilities, communication issues, and personnel errors, etc. Therefore, enhancing the cyber-resiliency of DER-based smart grid - the ability to survive successful cyber intrusions - is becoming increasingly vital and has garnered significant attention from both industry and academia. In this survey, we aim to provide a systematical and comprehensive review regarding the cyber-resiliency enhancement (CRE) of DER-based smart grid. Firstly, an integrated threat modeling method is tailored for the hierarchical DER-based smart grid with special emphasis on vulnerability identification and impact analysis. Then, the defense-in-depth strategies encompassing prevention, detection, mitigation, and recovery are comprehensively surveyed, systematically classified, and rigorously compared. A CRE framework is subsequently proposed to incorporate the five key resiliency enablers. Finally, challenges and future directions are discussed in details. The overall aim of this survey is to demonstrate the development trend of CRE methods and motivate further efforts to improve the cyber-resiliency of DER-based smart grid.Comment: Submitted to IEEE Transactions on Smart Grid for Publication Consideratio

Effects of Behavioral Interventions for Salt Reduction on Blood Pressure and Urinary Sodium Excretion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Hypertension is a prevalent cardiovascular condition, with excessive sodium intake being a significant risk factor. Various studies have investigated measures to reduce salt intake, including integrated lifestyle interventions and health education. However, the effectiveness of behavioral interventions focused solely on salt reduction remains unclear. This systematic review and meta-analysis aimed to investigate the effects of a behavioral intervention based on salt reduction on blood pressure and urinary sodium excretion. A comprehensive search of the Cochrane Central Register of Controlled Trials, EMBASE, PubMed, and Web of Science was conducted to identify relevant literature. Study and intervention characteristics were extracted for descriptive synthesis, and the quality of the included studies was assessed. A total of 10 studies, comprising 4,667 participants (3,796 adults and 871 children), were included. The interventions involved the provision of salt-restriction spoons or devices, salt-reduction education, self-monitoring devices for urinary sodium, and salt-reduction cooking classes. Meta-analysis results showed that behavioral interventions focused on salt reduction significantly reduced systolic blood pressure (SBP) (–1.17 mmHg; 95% CI, –1.86 to –0.49), diastolic blood pressure (DBP) (–0.58 mmHg; 95% CI, –1.07 to –0.08) and urinary sodium excretion (–21.88 mmol/24 hours; 95% CI, –32.12 to –11.64). These findings suggest that behavioral change interventions centered on salt reduction can effectively lower salt intake levels and decrease blood pressure levels. However, to enhance effectiveness, behavioral interventions for salt reduction should be combined with other salt-reduction strategies

Scheduling of EV Battery Swapping, II: Distributed Solutions

In Part I of this paper, we formulate an optimal scheduling problem for battery swapping that assigns to each electric vehicle (EV) a best station to swap its depleted battery based on its current location and state of charge. The schedule aims to minimize a weighted sum of EVs’ travel distance and electricity generation cost over both station assignments and power flow variables, subject to EV range constraints, grid operational constraints, and ac power flow equations. We propose there a centralized solution based on second-order cone programming relaxation of optimal power flow and generalized Benders decomposition that is applicable when global information is available. In this paper, we propose two distributed solutions based on the alternating direction method of multipliers and dual decomposition, respectively, that are suitable for systems where the distribution grid, stations, and EVs are managed by separate entities. Our algorithms allow these entities to make individual decisions, but coordinate through privacy-preserving information exchanges to solve a convex relaxation of the global problem. We present simulation results to show that both algorithms converge quickly to a solution that is close to optimum after discretization

Semaphorin 3A Contributes to Secondary Blood–Brain Barrier Damage After Traumatic Brain Injury

Semaphorin 3A (SEMA3A) is a member of the Semaphorins family, a class of membrane-associated protein that participates in the construction of nerve networks. SEMA3A has been reported to affect vascular permeability previously, but its influence in traumatic brain injury (TBI) is still unknown. To investigate the effects of SEMA3A, we used a mouse TBI model with a controlled cortical impact (CCI) device and a blood–brain barrier (BBB) injury model in vitro with oxygen-glucose deprivation (OGD). We tested post-TBI changes in SEMA3A, and its related receptors (Nrp-1 and plexin-A1) expression and distribution through western blotting and double-immunofluorescence staining, respectively. Neurological outcomes were evaluated by modified neurological severity scores (mNSSs) and beam-walking test. We examined BBB damage through Evans Blue dye extravasation, brain water content, and western blotting for VE-cadherin and p-VE-cadherin in vivo, and we examined the endothelial cell barrier through hopping probe ion conductance microscopy (HPICM), transwell leakage, and western blotting for VE-cadherin and p-VE-cadherin in vitro. Changes in miR-30b-5p were assessed by RT-PCR. Finally, the neuroprotective function of miR-30b-5p is measured by brain water content, mNSSs and beam-walking test. SEMA3A expression varied following TBI and peaked on the third day which expressed approximate fourfold increase compared with sham group, with the protein concentrated at the lesion boundary. SEMA3A contributed to neurological function deficits and secondary BBB damage in vivo. Our results demonstrated that SEMA3A level following OGD injury almost doubled than control group, and the negative effects of OGD injury can be improved by blocking SEMA3A expression. Furthermore, the expression of miR-30b-5p decreased approximate 40% at the third day and 60% at the seventh day post-CCI. OGD injury also exhibited an effect to approximately decrease 50% of miR-30b-5p expression. Additionally, the expression of SEMA3A post-TBI is regulated by miR-30b-5p, and miR-30b-5p could improve neurological outcomes post-TBI efficiently. Our results demonstrate that SEMA3A is a significant factor in secondary BBB damage after TBI and can be abolished by miR-30b-5p, which represents a potential therapeutic target

Creación y Simulación de Metodologías de Análisis, Clasificación e Integración de Nuevos Requerimientos a Software Propietario

La priorización de nuevos requerimientos a implementar en un software propietario es un punto fundamental para su mantenimiento, la conservación de la calidad, observación de las reglas de negocio y los estándares de la empresa. Aunque existen herramientas de priorización basadas en técnicas probadas y reconocidas, las mismas requieren una calificación previa de cada requerimiento. Si la empresa cuenta con solicitudes provenientes de varios clientes de un mismo producto, aumentan los factores que afectan a la empresa, las herramientas disponibles no contemplan estos aspectos y hacen mucho más compleja la tarea de calificación. Este trabajo de investigación abarca la realización de un relevamiento de los métodos de priorización y selección de nuevos requerimientos utilizados por empresas de la zona de Rosario, y la definición de una metodología para la selección un nuevo requerimiento, que implica el análisis y evaluación de todas las implicaciones sobre el producto de software y la empresa, respetando sus reglas de negocio. La metodología creada conduce a la definición de los procesos para la construcción de una herramienta de calificación y priorización de nuevos requerimientos en software propietario que tiene solicitudes de varios clientes al mismo tiempo, con instrumentos de calificación que consideran todos los aspectos relacionados, proveerá técnicas de priorización actuales y emitirá informes personalizados según diferentes perspectivas de la empresa.Eje: Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI

The Determinants of Grape Storage: Evidence from Grape Growers in China

Storage of high-value agricultural products is essential to increase their added value. Exploring growers’ storage strategies for high-value agricultural products is helpful in developing the agricultural industry. In this paper, we analyzed the factors affecting growers’ storage decisions using Probit and Tobit models based on field data from 1026 grape growers in China. We conclude that the in-season price has a negative effect on growers’ storage decisions. Expected price, market risk perception and grape quality have a positive effect on storage decisions. Borrowing behavior has a positive effect on the storage decisions of large-scale growers. In addition, the higher the expected price and the greater the market risk perception, the more growers prefer long-term storage; and the better the quality of the grapes, the more growers tend to store grapes in the short term

Morphology-Variable Aggregates Prepared from Cholesterol-Containing Amphiphilic Glycopolymers: Their Protein Recognition/Adsorption and Drug Delivery Applications

In this study, a series of diblock glycopolymers, poly(6-O-methacryloyl-d-galactopyranose)-b-poly(6-cholesteryloxyhexyl methacrylate) (PMAgala-b-PMAChols), with cholesterol/galactose grafts were prepared through a sequential reversible addition-fragmentation chain transfer (RAFT) polymerization and deprotection process. The glycopolymers could self-assemble into aggregates with various morphologies depending on cholesterol/galactose-containing block weight ratios, as determined by transmission electronic microscopy (TEM) and dynamic laser light scattering (DLS). In addition, the lectin (Ricinus communis agglutinin II, RCA120) recognition and bovine serum albumin (BSA) adsorption of the PMAgala-b-PMAChol aggregates were evaluated. The SK-Hep-1 tumor cell inhibition properties of the PMAgala-b-PMAChol/doxorubicin (DOX) complex aggregates were further examined in vitro. Results indicate that the PMAgala-b-PMAChol aggregates with various morphologies showed different interaction/recognition features with RCA120 and BSA. Spherical aggregates (d ≈ 92 nm) possessed the highest RCA120 recognition ability and lowest BSA protein adsorption. In addition, the DOX-loaded spherical complex aggregates exhibited a better tumor cell inhibition property than those of nanofibrous complex aggregates. The morphology-variable aggregates derived from the amphiphilic glycopolymers may serve as multifunctional biomaterials with biomolecular recognition and drug delivery features

Cooperative Networking towards Maritime Cyber Physical Systems

An innovative paradigm named Cooperative Cognitive Maritime Cyber Physical Systems (CCMCPSs) is developed to achieve high-speed and low-cost communication services. The analysis of the available white space at sea, as well as the framework, is presented. Specifically, a bilevel game with two stages of PUs-to-SUs (primary users to secondary users) and SUs-to-SUs is proposed, to address the resource allocation issue of Decode-and-Forward (DF) relay mode with maximal-ratio combining (MRC) receiving mode in destination. Stackelberg game with priority is employed between PU and SUs, while a symmetrical system model is considered among SUs-to-SUs. The game theoretic procedure that converges to Nash equilibrium based on the utility and payoff function is illustrated. Simulation results demonstrate that our proposed strategy could effectively increase the throughput as well as the payoffs of the system

Prodrug Systems (I): Lipid-based Doxorubicin Prodrugs and their nanodelivery systems

Using natural lipids to covalently connect with antitumor agents to construct lipid-based molecular prodrugs and their nanosystems is a promising research frontier for sustainable medicinal chemistry, nanobiotechnology and tumor chemotherapy. This paper reviewed recent progress of lipid-based doxorubicin (molecular) prodrugs and their nanodelivery systems, including lipid-doxorubicin prodrugs, stimuli-responsive lipid-doxorubicin prodrugs, and lipid-doxorubicin prodrug-based drug co-delivery nanosystems. Additionally, possible future research outlooks in this field were also discussed.info:eu-repo/semantics/publishedVersio

Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization

Using renewable and biocompatible natural-based resources to construct functional biomaterials has attracted great attention in recent years. In this work, we successfully prepared a series of steroid-based cationic lipids by integrating various steroid skeletons/hydrophobes with (l-)-arginine headgroups via facile and efficient synthetic approach. The plasmid DNA (pDNA) binding affinity of the steroid-based cationic lipids, average particle sizes, surface potentials, morphologies and stability of the steroid-based cationic lipids/pDNA lipoplexes were disclosed to depend largely on the steroid skeletons. Cellular evaluation results revealed that cytotoxicity and gene transfection efficiency of the steroid-based cationic lipids in H1299 and HeLa cells strongly relied on the steroid hydrophobes. Interestingly, the steroid lipids/pDNA lipoplexes inclined to enter H1299 cells mainly through caveolae and lipid-raft mediated endocytosis pathways, and an intracellular trafficking route of “lipid-raft-mediated endocytosis→lysosome→cell nucleic localization” was accordingly proposed. The study provided possible approach for developing high-performance steroid-based lipid gene carriers, in which the cytotoxicity, gene transfection capability, endocytosis pathways, and intracellular trafficking/localization manners could be tuned/controlled by introducing proper steroid skeletons/hydrophobes. Noteworthy, among the lipids, Cho-Arg showed remarkably high gene transfection efficacy, even under high serum concentration (50% fetal bovine serum), making it an efficient gene transfection agent for practical application