She? The Role of Perceived Agent Gender in Social Media Customer Service

This paper investigated the role of perceived agent gender in customer behavior using a unique dataset from Southwest Airlines\u27 Twitter account. We inferred agent gender based on the first names provided by agents when responding to customers. We measured customer behavior using three outcomes: whether a customer decided to continue the service conversation upon receiving an agent’s initial response as well as the valence and arousal levels in their second tweet if the customer chose to continue the interaction. Our identification strategy relied on the Backdoor Criterion and hinged on the assumption that customer service requests are assigned to the next available agent, independent of agent gender. The findings revealed that customers were more likely to continue interactions with female agents than male agents and they were more negative in valence but less intense in arousal with the former group than with the latter

GAMENet: Graph Augmented MEmory Networks for Recommending Medication Combination

Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing approaches either do not customize based on patient health history, or ignore existing knowledge on drug-drug interactions (DDI) that might lead to adverse outcomes. To fill this gap, we propose the Graph Augmented Memory Networks (GAMENet), which integrates the drug-drug interactions knowledge graph by a memory module implemented as a graph convolutional networks, and models longitudinal patient records as the query. It is trained end-to-end to provide safe and personalized recommendation of medication combination. We demonstrate the effectiveness and safety of GAMENet by comparing with several state-of-the-art methods on real EHR data. GAMENet outperformed all baselines in all effectiveness measures, and also achieved 3.60% DDI rate reduction from existing EHR data.Comment: AAAI 2019; change the template and fix some typo

X-PuDu at SemEval-2022 Task 7: A Replaced Token Detection Task Pre-trained Model with Pattern-aware Ensembling for Identifying Plausible Clarifications

This paper describes our winning system on SemEval 2022 Task 7: Identifying Plausible Clarifications of Implicit and Underspecified Phrases in Instructional Texts. A replaced token detection pre-trained model is utilized with minorly different task-specific heads for SubTask-A: Multi-class Classification and SubTask-B: Ranking. Incorporating a pattern-aware ensemble method, our system achieves a 68.90% accuracy score and 0.8070 spearman's rank correlation score surpassing the 2nd place with a large margin by 2.7 and 2.2 percent points for SubTask-A and SubTask-B, respectively. Our approach is simple and easy to implement, and we conducted ablation studies and qualitative and quantitative analyses for the working strategies used in our system.Comment: Accepted at the 16th International Workshop on Semantic Evaluation (SemEval-2022), NAAC

Connections Between Connexins, Calcium, and Cataracts in the Lens

There is a good deal of evidence that the lens generates an internal micro circulatory system, which brings metabolites, like glucose, and antioxidants, like ascorbate, into the lens along the extracellular spaces between cells. Calcium also ought to be carried into the lens by this system. If so, the only path for Ca2+ to get out of the lens is to move down its electrochemical gradient into fiber cells, and then move by electrodiffusion from cell to cell through gap junctions to surface cells, where Ca-ATPase activity and Na/Ca exchange can transport it back into the aqueous or vitreous humors. The purpose of the present study was to test this calcium circulation hypothesis by studying calcium homeostasis in connexin (Cx46) knockout and (Cx46 for Cx50) knockin mouse lenses, which have different degrees of gap junction coupling. To measure intracellular calcium, FURA2 was injected into fiber cells, and the gradient in calcium concentration from center to surface was mapped in each type of lens. In wild-type lenses the coupling conductance of the mature fibers was ∼0.5 S/cm2 of cell to cell contact, and the best fit to the calcium concentration data varied from 700 nM in the center to 300 nM at the surface. In the knockin lenses, the coupling conductance was ∼1.0 S/cm2 and calcium varied from ∼500 nM at the center to 300 nM at the surface. Thus, when the coupling conductance doubled, the concentration gradient halved, as predicted by the model. In knockout lenses, the coupling conductance was zero, hence the efflux path was knocked out and calcium accumulated to ∼2 μM in central fibers. Knockout lenses also had a dense central cataract that extended from the center to about half the radius. Others have previously shown that this cataract involves activation of a calcium-dependent protease, Lp82. We can now expand on this finding to provide a hypothesis on each step that leads to cataract formation: knockout of Cx46 causes loss of coupling of mature fiber cells; the efflux path for calcium is therefore blocked; calcium accumulates in the central cells; at concentrations above ∼1 μM (from the center to about half way out of a 3-wk-old lens) Lp82 is activated; Lp82 cleaves cytoplasmic proteins (crystallins) in central cells; and the cleaved proteins aggregate and scatter light

Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration

Stem cell transplantation has been proved a promising therapeutic instrument in intervertebral disc degeneration (IVDD). However, the elevation of oxidative stress in the degenerated region impairs the efficiency of mesenchymal stem cells (BMSCs) transplantation treatment via exaggeration of mitochondrial ROS and promotion of BMSCs apoptosis. Herein, we applied an emulsion-confined assembly method to encapsulate Coenzyme Q10 (Co-Q10), a promising hydrophobic antioxidant which targets mitochondria ROS, into the lecithin micelles, which renders the insoluble Co-Q10 dispersible in water as stable colloids. These micelles are injectable, which displayed efficient ability to facilitate Co-Q10 to get into BMSCs in vitro, and exhibited prolonged release of Co-Q10 in intervertebral disc tissue of animal models. Compared to mere use of Co-Q10, the Co-Q10 loaded micelle possessed better bioactivities, which elevated the viability, restored mitochondrial structure as well as function, and enhanced production of ECM components in rat BMSCs. Moreover, it is demonstrated that the injection of this micelle with BMSCs retained disc height and alleviated IVDD in a rat needle puncture model. Therefore, these Co-Q10 loaded micelles play a protective role in cell survival and differentiation through antagonizing mitochondrial ROS, and might be a potential therapeutic agent for IVDD

Cooperative Transmission Strategy Over Users’ Mobility for Downlink Distributed Antenna Systems

Previously, a scheme in [1] is proposed for the outdated channel state information (CSI) problem, for data transmission in time division duplex (TDD) systems. In user movement environment, the actual channel of data transmission at downlink time slot is different from the estimated channel due to channel variation. In this paper the effect of different user mobility on TDD downlink multiuser distributed antenna system is investigated. An efficient autocorrelation based feedback interval technique is proposed and updates CSI at less cost of the downlink time slots. In the proposed technique, the frequency of CSI feedback for different users is proportional to their speed. Cooperative clusters are formed to maximize sum rate where channel gain based antenna selection and user clustering based on SINR threshold is applied to reduce computational complexity. Numerical results show that sum rate superiority of the proposed scheme over the user mobility

Pharmacokinetics of single- and multiple-dose flumatinib in patients with chronic phase chronic myeloid leukemia

IntroductionFlumatinib is a novel, oral breakpoint cluster region-abelson (BCR-ABL) tyrosine kinase inhibitor that has demonstrated manageable safety and promising efficacy in patients with newly diagnosed chronic phase (CP) chronic myeloid leukemia (CML). MethodsThis study evaluated the pharmacokinetic (PK) profiles of flumatinib mesylate tablets at a dose of 400 mg and 600 mg in patients with CML-CP. The study was registered at chictr.org Identifier (ChiCTR2100044700). In this open-label, pharmacokinetic study, eligible patients were administered a single-dose of flumatinib 400 mg or 600 mg on day 1, followed by 2-day washout and 8 consecutive days of once-daily administration. Serial plasma samples were assayed for flumatinib and its metabolites (N-demethylate metabolite M1 and amide-bond hydrolytic metabolite M3).ResultsTwenty-nine patients were assigned to flumatinib 400 mg (n=14) or 600 mg (n=15). Serum concentrations of flumatinib reached maximum measured plasma concentration (Cmax) at a median time of 2 hours after each single dose, and then eliminated slowly with a mean apparent terminal disposition half-life (t1/2) from 16.0 to 16.9 hours. Following single- and multiple-dose administration, flumatinib exposure (Cmax, area under the concentration-time curve from 0 to t hours (AUC0-t), area under the concentration-time curve from 0 hours to infinity (AUC0-∞)) increased in an approximately dose-proportional manner. There was approximately 4.1- and 3.4- fold drug accumulation at steady-state after multiple-dose administration at 400 mg and 600 mg, respectively. The drug-related AEs associated with both treatments were primarily low-grade and tolerable events.ConclusionAnalysis of PK parameters indicated that flumatinib exposure increased in an approximately dose-proportional manner. Further research needs to be conducted in a large sample-size study