160 research outputs found

    Special Libraries, January 1925

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    Volume 16, Issue 1https://scholarworks.sjsu.edu/sla_sl_1925/1000/thumbnail.jp

    A feasibility study on using smartphones to conduct short-version verbal autopsies in rural China

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    Background: Currently there are two main sources of mortality data with cause of death assignments in China. Both sources-the Ministry of Health-Vital Registration system and the Chinese Disease Surveillance Point system-present their own challenges. A new approach to cause of death assignment is a smartphone-based shortened version of a verbal autopsy survey. This study evaluates the feasibility and acceptability of this new method conducted by township health care providers (THP) and village doctors (VD) in rural China, where a large proportion of deaths occur in homes and cause of death data are inaccurate or lacking. Methods: The Population Health Metrics Research Consortium mobile phone-based shortened verbal autopsy questionnaire was made available on an Android system-based application, and cause of death was derived using the Tariff method (Tariff 2.0); we called this set of tools "msVA." msVA was administered to relatives of the deceased by six THPs and six VDs in 24 villages located in six townships of Luquan County, Hebei Province, China. Subsequently, interviews were conducted among 12 interviewers, 12 randomly selected respondents, and five study staff to assess the feasibility and acceptability of using msVA for mortality data collection. Results: Between July 2013 and August 2013, 268 deaths took place in the study villages. Among the 268 deaths, 227 VAs were completed (nine refusals, 31 migrations and one loss of data due to breakdown of the smartphone). The average time for a VA interview was 21.5 +/- 3.4 min (20.1 +/- 3.5 min for THP and 23.2 +/- 4.1 min for VD). Both THPs and VDs could be successful interviewers; the latter needed more training but had more willingness to implement msVA in the future. The interviews revealed that both interviewers and relatives of the deceased found msVA to be feasible, acceptable, and more desirable than traditional methods. The cost of conducting a new VA was $ 8.87 per death. Conclusions: Conduction of msVA by VDs in their own villages was feasible and acceptable in rural northern China. Broader implementation of msVA across rural China could potentially improve the coverage and quality of cause of death data, allowing for better national health evaluation and program planning.National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services [HHSN268200900034C]; NHLBI-UHG Trainee Seed [email protected]

    Electrospun ZnO/Bi 2

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    ZnO/Bi2O3 nanofibers were synthesized by a simple electrospinning method and both the UV and visible light responsive photocatalytic properties were studied by the decolorization of RhB dye. Thermogravimetric analysis/differential thermal analysis (TGA-DTA), X-ray diffraction (XRD), scanning electron microscope (SEM), and UV-vis diffuse reflectance spectra (DRS) were employed to study the structure, morphology, and optical properties of the ZnO/Bi2O3 nanofibers, respectively. The relationship between the ZnO/Bi2O3 ratio and photocatalytic activity was also studied, and the composite with a molar ratio of 23 : 1 demonstrated the best activity under both excitations. The photocatalytic mechanisms for the composite fibers can be described as the direct photocatalysis under UV excitation and photosensitation for visible light irradiation. The enhanced photocatalytic activities can be ascribed to the effective electron-hole pairs separation that leads to the promoted photocatalytic efficiency

    Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274

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    <p>Abstract</p> <p>Background</p> <p>c-Met is a receptor tyrosine kinase (RTK) that is over-expressed in a variety of cancers and involved in cell growth, invasion, metastasis and angiogenesis. In this study, we investigated the role of c-Met in rhabdomyosarcoma (RMS) using its small molecule inhibitor SU11274, which has been hypothesized to be a potential therapeutic target for RMS.</p> <p>Methods</p> <p>The expression level of phosphorylated c-Met in RMS cell lines (RD, CW9019 and RH30) and tumor tissues was assessed by phospho-RTK array and immunohistochemistry, respectively. The inhibition effects of SU11274 on RMS cells were studied with regard to intracellular signaling, cell proliferation, cell cycle and cell migration.</p> <p>Results</p> <p>A high level of phosphorylated c-Met was detected in 2 alveolar RMS cell lines (CW9019 and RH30) and 14 out of 24 RMS tissue samples, whereas relatively low levels of phospho-c-Met were observed in the embryonic RMS cell line (RD). The small molecule SU11274 could significantly reduce the phosphorylation of c-Met, resulting in inhibition of cell proliferation, G1 phase arrest of cell cycle and blocking of cell migration in CW9019 and RH30 cell lines.</p> <p>Conclusion</p> <p>These results might support the role of c-Met in the development and progression of RMS. Furthermore, the inhibitor of c-Met, SU11274, could be an effective targeting therapy reagent for RMS, especially alveolar RMS.</p
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