Investigations on physicochemical properties and electrochemical performance of graphite felt and carbon felt for iron‐chromium redox flow battery

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Learning Pregrasp Manipulation of Objects from Ungraspable Poses

In robotic grasping, objects are often occluded in ungraspable configurations such that no pregrasp pose can be found, eg large flat boxes on the table that can only be grasped from the side. Inspired by humans' bimanual manipulation, eg one hand to lift up things and the other to grasp, we address this type of problems by introducing pregrasp manipulation - push and lift actions. We propose a model-free Deep Reinforcement Learning framework to train control policies that utilize visual information and proprioceptive states of the robot to autonomously discover robust pregrasp manipulation. The robot arm learns to first push the object towards a support surface and establishes a pivot to lift up one side of the object, thus creating a clearance between the object and the table for possible grasping solutions. Furthermore, we show the effectiveness of our proposed learning framework in training robust pregrasp policies that can directly transfer from simulation to real hardware through suitable design of training procedures, state, and action space. Lastly, we evaluate the effectiveness and the generalisation ability of the learned policies in real-world experiments, and demonstrate pregrasp manipulation of objects with various size, shape, weight, and surface friction.Comment: 8 pages open access version for ICRA2020 6 pages acceptance pape

The content and distribution of Ge in the sediments of Prydz Bay, Antarctica

The content and distribution of Ge is investigated in sediments from the Southern Ocean (Prydz Bay, Antarctica). The content of Getotal in the sediments ranges from 1.14×10-6 to 2.35×10-6 (average of 1.71×10-6) and the highest value occurs at station P3-9 where water depth is > 1 000 m. The lowest value occurs at station P4-13 which is near the edge of the Amery ice shelf. The surface sediments have 16%–68% Gebio within Getotal. The distribution trends of Gebio and Getotal are generally similar, and the values outside Prydz Bay are higher than within the bay, bounded at 67°S. The vertical distribution of Ge in sediment cores presents higher values at the surface than in underlying sediments. Values of Gebio appear to positively correlate with biogenic silica (BSiO2) in surface sediments from non-polynyas sea. The vertical distribution of Gebio and BSiO2 is similar in sediments of station P3-16

Periostin: a promising target of therapeutical intervention for prostate cancer

<p>Abstract</p> <p>Background</p> <p>In our recent study, Periostin was up-regulated in prostate cancer(PCa) compared with benign prostate hyperplasia (BPH) by proteomics analysis of prostate biopsies. We investigated the effect of sliencing Periostin by RNA interference (RNAi) on the proliferation and migration of PCa LNCap cell line.</p> <p>Methods</p> <p>All the prostate biopsies from PCa, BPH and BPH with local prostatic intraepithelial neoplasm(PIN) were analyzed by iTRAQ(Isobaric tags for relative and absolute quantification) technology. Western blotting and immunohistochemical staining were used to verify Periostin expression in the tissues of PCa. Periostin expression in different PCa cell lines was determined by immunofluorescence staining, western blotting and reverse transcription PCR(RT-PCR). The LNCap cells with Periostin expression were used for transfecting shRNA-Periostin lentiviral particles. The efficancy of transfecting shRNA lentiviral particles was evaluated by immunofluorescence, western blotting and Real-time PCR. The effect of silencing Periostin expression by RNAi on proliferation of LNCap cells was determined by MTT assay and tumor xenografts. The tissue slices from theses xenografts were analyzed by hematoxylin and eosin(HE) staining. The expression of Periostin in the xenografts was deteminned by Immunohistochemical staining and western blotting. The migration of LNCap cells after silencing Periostin gene expression were analyzed in vitro.</p> <p>Results</p> <p>Periostin as the protein of interest was shown 9.12 fold up-regulation in PCa compared with BPH. The overexpression of Periostin in the stroma of PCa was confirmed by western blotting and immunohistochemical staining. Periostin was only expressed in PCa LNCap cell line. Our results indicated that the transfection ratio was more than 90%. As was expected, both the protein level and mRNA level of Periostin in the stably expressing shRNA-Periostin LNCap cells were significantly reduced. The stably expressing shRNA-Periostin LNCap cells growed slowly in vitro and in vivo. The tissues of xenografts as PCa were verificated by HE staining. Additionally, the weak positive Periostin expressed tumor cells could be seen in the tissues of 6 xenografts from the group of down-regulated Periostin LNCap cells which had a significant decrease of the amount of Periostin compared to the other two group. Furthermore, our results demonstrated that sliencing Periostin could inhibit migration of LNCap cells in vitro.</p> <p>Conclusions</p> <p>Our data indicates that Periostin as an up-regulated protein in PCa may be a promising target of therapeutical intervention for PCa in future.</p

Periostin identified as a potential biomarker of prostate cancer by iTRAQ-proteomics analysis of prostate biopsy

<p>Abstract</p> <p>Background</p> <p>Proteomics may help us better understand the changes of multiple proteins involved in oncogenesis and progression of prostate cancer(PCa) and identify more diagnostic and prognostic biomarkers. The aim of this study was to screen biomarkers of PCa by the proteomics analysis using isobaric tags for relative and absolute quantification(iTRAQ).</p> <p>Methods</p> <p>The patients undergoing prostate biopsies were classified into 3 groups according to pathological results: benign prostate hyperplasia (BPH, n = 20), PCa(n = 20) and BPH with local prostatic intraepithelial neoplasm(PIN, n = 10). Then, all the specimens from these patients were analyzed by iTRAQ and two-dimensional liquid chromatography-tandem mass spectrometry (2DLC-MS/MS). The Gene Ontology(GO) function and the transcription regulation networks of the differentially expressed were analyzed by MetaCore software. Western blotting and Immunohistochemical staining were used to analyze the interesting proteins.</p> <p>Result</p> <p>A total of 760 proteins were identified from 13787 distinct peptides, including two common proteins that enjoy clinical application: prostate specific antigen (PSA) and prostatic acid phosphatase(PAP). Proteins that expressed differentially between PCa and BPH group were further analyzed. Compared with BPH, 20 proteins were significantly differentially up-regulated (>1.5-fold) while 26 were significantly down-regulated in PCa(<0.66-fold). In term of GO database, the differentially expressed proteins were divided into 3 categories: cellular component(CC), molecular function (MF) and biological process(BP). The top 5 transcription regulation networks of the differentially expressed proteins were initiated through activation of SP1, p53, YY1, androgen receptor(AR) and c-Myc The overexpression of periostin in PCa was verified by western blotting and immunohistochemical staining.</p> <p>Conclusion</p> <p>Our study indicates that the iTRAQ technology is a new strategy for global proteomics analysis of the tissues of PCa. A significant up-regulation of periostin in PCa compared to BPH may provide clues for not only a promising biomarker for the prognosis of PCa but also a potential target for therapeutical intervention.</p

Research on large-scale clean energy optimal scheduling method based on multi-source data-driven

With the large-scale growth and grid connection of intermittent renewable energy such as wind and solar, the problem of increasing renewable energy curtailment rate and system backup flexibility has become increasingly prominent. In order to solve the problem of high proportion of renewable energy scientific consumption and flexible and stable operation of energy system. We propose a flexible and economical dispatch method based on data-driven multi-regional power system. For the problem of economic dispatch of multi-area power system, a mathematical calculation model is established to satisfy the constraints of unit output, system power balance, unit ramp rate, and valve point effect, and to consider the requirement of minimizing the cost of multi-area power load comprehensively. Based on data-driven, this paper adopts an improved fruit fly optimization algorithm to quickly find the global optimal solution. The calculations are performed by IEEE6 simulation test system, and the results verify the feasibility of the proposed algorithm. The improved fruit fly optimization algorithm is compared and analyzed with other algorithms considering the quality of the obtained solutions. The results show the effectiveness and superiority of the proposed algorithm in solving multi-area economic dispatching problems in real power systems

Surgical Treatment for 11 Cases of Penile Verrucous Carcinoma

Penile verrucous carcinoma is a rare, well-differentiated and low-grade tumor. The surgeons are deficiently aware about the biological behavior and the clinicopathological characteristic of this disease, which raises difficulties during the treatment. In our present study, the clinical and pathological data of 11 patients with penile verrucous carcinoma, aged between 49 to 85 years was retrospectively analyzed. The tumors exhibited exophytic, papillary, caulifower-like or verrucose lesions of great dimensions measuring between 2 to 10 cm on the penises. The tumors were located at glans in 6 cases, invaded the coronoid sulcus in 4 cases and invaded the shaft of the penis in 1 case. Eight cases underwent partial penectomy, while the other 3 were treated with local excision. The diagnosis of penile verrucous carcinoma was confirmed by histopathologic examination of the specimens with the negative surgical margins in all the cases. Within the period of 12 to 60 months of follow-up, all the patients were disease-free with no case of recurrence and metastasis. The novel knowledge and experience of the treatment of penile verrucous carcinoma will be a useful clinical guide for surgeons in the future

Retroperitoneal Laparoscopic Ureterolithotomy for Proximal Ureteral Calculi in Selected Patients

Objectives. To summarize our experience of retroperitoneal laparoscopic ureterolithotomy for ureteral calculi and evaluate the safety and efficiency of this procedure. Methods. We conducted a retrospective analysis of 197 patients with proximal ureteral calculi who accepted retroperitoneal laparoscopic ureterolithotomy from June 2005 to June 2014. Results. All procedures were performed successfully and the mean operating time and estimated blood loss were 87 min and 64 mL. The clearance rate was 98.5% and the rates of urine leak and ureteral stricture were 2.5% and 1.0%. Conclusions. Retroperitoneal laparoscopic ureterolithotomy is a safe and effective procedure for patients with complex stones or anatomic abnormalities, and, with experience of high volume series, it is also a reasonable choice as the primary treatment for such selected patients