Classical Hodgkin's lymphoma with cutaneous involvement in an adolescent male: A case study

Background: Hodgkin's lymphoma (HL) with skin involvement is reasonably rare. It typically occurs late in the course and is associated with a poor prognosis; however, it may also be indolent in some cases. Case: We report a case of a 15-year-old previously healthy male with Hodgkin's lymphoma who presented with multiple lymphadenopathies of axilla and serpiginous ulcerative nodular lesions involving pectoral skin. A lymph node biopsy was performed following an initial diagnostic workup for a suspected active infectious disease, which revealed a neoplastic invasion from a mixed cellularity classical HL with skin involvement. A total of six cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy regimen was administered to the patient. Conclusion: In comparison to other studies, this case demonstrates that a good response is possible with standard ABVD chemotherapy

Epidemiological study of human rabies cases in Bangladesh through verbal autopsy

Identification of risk factors is crucial to find ways to reduce rabies deaths. We investigated the hospital records of rabies deceased through contact tracing of the relatives of the victims using enhanced verbal autopsies (VA) to identify why the people had to die from rabies in recent years in Bangladesh. Patients whose deaths were confirmed by physicians based on the history of animal exposure and clinical signs were taken into account for VA. Socio-demographic profile of the deceased, animal exposure, nature of the wound, and history of postexposure prophylaxis (PEP) data were obtained and analysed. The study found 256 cases in which the cause of death was attributed to rabies, most of the victims were male (71.88%), resided in the rural community (80.47%), dependent (49.22%), and children below the age of 15 years (47.27%). Dogs were the single most responsible (81.64%); however, cats (12.11%), jackals (3.91%) and mongoose (2.34%) were also found accountable for rabies incidence (P< 0.05). Significantly, limbs were the most common (67.97%) site of exposure, and the shortest incubation period was identified in the case of bites to head and face (P < 0.05). The majority (86.72%) of the deceased did not receive any PEP; whereas, 66.80% sought treatment from traditional healers. Among the deceased (13.28%, n¼ 34) who had received PEP, only 8.82% of them completed the full course of the vaccination regimen (P< 0.01); however, none of them had history of taking rabies immunoglobulin (RIG). The study recommends extensive public health awareness programs in the rural community and establishing methods to improve healthcare-seeking behaviours, including receiving PEP instead of visiting traditional healers. Moreover, the availability and accessibility of PEP in the government hospital facilities are desirable, and laboratory-based surveillance with compatible rapid data reporting may be incorporated in the existing policy

MATERIALS AND METHODS

This study was carried out to assess the status of household ducks and factors affects the producti vity of ducks in Companiganj upazila under Noakhali district of Bangladesh. For this study the information was collected by direct interview using a questionnaire from 30 households. The study showed that duck rearing was mostly lead by the women (80%) and their level of education varied from primary (43%) to higher secondary (7%). The average farm size was found to be six and they were mostly local ducks (90%). Marshy land s were common (67%) to the surroundings of the duck habitats. Most of the farmers depended on natural feed sources (60%) while some provided supplementary feed (40%) for their ducks. As a supplementary feed, 27% of the farmers used rice polish and17% used a mixture of rice polish and boil rice. Duck started their first laying at 6 months of age and the mean egg production per duck per year was 114 ±16 no. The diseases were more common during winter (63%) than other seasons of the year. It was found that good egg production (> mean production) was associated with the regular use of anthelmintics, supplementary feed, presence of marshy land and regular treatment. Zending was found to be good egg producer in marshy area than other three native breeds of ducks

Socio-Economic Burden of Tuberculosis among Hospitalized Patients in Dhaka City, Bangladesh

Tuberculosis (TB) affects the most productive age group people, resulting in economic loss to the individual and their family, particularly in developing countries. This study aimed to assess the economic burden of TB in Hospitalized patients. We conducted a cross-sectional survey among hospitalized TB patients who visited the National Institute of Chest Disease and Hospital, Dhaka, Bangladesh from June 2017 through February 2018. Most TB patients were male (95%) with the age group between 36 and 50 years (42.3%). A majority of the patients (96%) came to the hospital for retreatment of TB. Two-third of the patients went to the hospital from rural areas. The average cost for treating individual TB patients was ~600 US$ (United States dollar). The average productive days lost of a TB patient were 141 days. TB patients from rural areas spent more money than patients living in urban and semi-urban areas. More awareness is needed, particularly in rural people about the current TB burden, nearest TB treatment facilities, and the National Tuberculosis Control Program to minimize economic loss. These study findings also demand the establishment of a specialized TB hospital at the sub-district level

Antibiotic Use Among Children Under 5 Years of Age in a Tertiary Care Hospital, Bangladesh

Antimicrobial resistance is common in low-middle-income countries caused by inappropriate and irrational use of antibiotics in humans and animals. Bangladesh has very limited information on antibiotic use and associated resistance. This study explored the prescribing pattern of antibiotics uses among children visiting a tertiary care hospital in Bangladesh. We conducted a crosssectional study among 400 hospitalized children less than 5 years of age from February to April, 2019, in a tertiary hospital in Bangladesh. Among the 400 children, >50% belonged to the age group for less than 1 year and >60% were male. The average hospital stay period was 3 days (range 1–14 days). The majority of the children had a history of respiratory illnesses (32.2%) and 31% had diarrhea. Most of the children (81.7%) were prescribed one or more antibiotics. The average number of antibiotics per child was 1.17. A combined form of antibiotics was prescribed in 17.43% of children. A total of 14 different antibiotics were prescribed. The most common antibiotic was ceftriaxone (62.39%), followed by azithromycin (18.65%). The parental route was mostly preferred (74.92%) for antibiotic administration. The antibiotic prescription was common in children less than 5 years of age visiting a tertiary level hospital. Most of the prescribed antibiotics were broad spectrum that can promote bacterial resistance. The study’s finding is useful to draw attention to the public health policymakers for taking necessary actions on the appropriate use of antibiotics among children in Bangladesh

Fixed points of generalized cyclic contractions without continuity and application to fractal generation

In this paper, we define a generalized cyclic contraction and prove a unique fixed point theorem for these contractions. An illustrative example is given, which shows that these contraction mappings may admit the discontinuities and also that an existing result in the literature is effectively generalized by the theorem. We apply the fixed point result for generation of fractal sets through construction of an iterated function system and the corresponding Hutchinsion–Barnsley operator. The above construction is illustrated by an example. The study here is in the context of metric spaces

The Pattern of Highly Pathogenic Avian Influenza H5N1 Outbreaks in South Asia

ighly pathogenic avian influenza (HPAI) H5N1 has caused severe illnesses in poultry and in humans. More than 15,000 outbreaks in domestic birds from 2005 to 2018 and 861 human cases from 2003 to 2019 were reported across the world to OIE (Office International des Epizooties) and WHO (World Health Organization), respectively. We reviewed and summarized the spatial and temporal distribution of HPAI outbreaks in South Asia. During January 2006 to June 2019, a total of 1063 H5N1 outbreaks in birds and 12 human cases for H5N1 infection were reported to OIE and WHO, respectively. H5N1 outbreaks were detected more in the winter season than the summer season and PubMed to collect data from published articles using the followin

Prevalence and antimicrobial susceptibility profiles of nontyphoidal Salmonella isolated from chickens in Rajshahi, Bangladesh

Salmonellosis in poultry is an important disease that seriously impedes the development of the poultry industry. The increased resistance to antimicrobials against Salmonella has been a major public health concern worldwide. We conducted a study from January to June 2016 in and around the Rajshahi district of Bangladesh on the commercial chicken to isolate, identify and characterize poultryspecific Salmonella, to assess the potential risk factors and to determine the antimicrobial resistance pattern of the isolates. The overall prevalence of Salmonella enterica was 41% (49/120) [95% CI: 31.95%– 50.17%] with 41.7% in broiler chicken (25/60) [95% CI: 29.06%– 55.12%] and 40% in layer chicke

Major zoonotic diseases of public health importance in Bangladesh

Zoonotic diseases cause repeated outbreaks in humans globally. The majority of emerging infections in humans are zoonotic. COVID19 is an ideal example of a recently identified emerging zoonotic disease, causing a global pandemic. Anthropogenic factors such as modernisation of agriculture and livestock farming, wildlife hunting, the destruction of wild animal habitats, mixing wild and domestic animals, wildlife trading, changing food habits and urbanisation could drive the emergence of zoonotic diseases in humans. Since 2001, Bangladesh has been reporting many emerging zoonotic disease outbreaks such as nipah, highly pathogenic avian influenza, pandemic H1N1, and COVID19. There are many other potential zoonotic pathogens such as Ebola, Middle East respiratory syndrome coronavirus, Kyasanur forest disease virus and Crimean– Congo haemorrhagic fever that may emerge in the future. However, we have a limited understanding of zoonotic diseases’ overall risk in humans and associated factors that drive the emergence of zoonotic pathogens. This narrative review summarised the major emerging, reemerging, neglected and other potential zoonotic diseases in Bangladesh and their associated risk factors. Nipah virus and Bacillus anthracis caused repeated outbreaks in humans. More than 300 human cases with Nipah virus infection were reported since the first outbreak in 2001. The highly pathogenic avian influenza virus (H5N1) caused more than 550 outbreaks in poultry, and eight human cases were reported so far since 2007. People of Bangladesh are frequently exposed to zoonotic pathogens due to close interaction with domestic and peridomestic animals. The rapidly changing intensified animal– human– ecosystem interfaces and risky practices increase the risk of zoonotic disease transmission. The narrative review's findings are useful to draw attention to the risk and emergence of zoonotic diseases to public health policymakers in Bangladesh and the application of onehealth approach to address this public health threat. We conducted a narrative review of the published literature with a focus on zoonotic diseases reported from Bangladesh. Relevant research articles, review articles, abstracts, case reports, communications, letters, book chapters, conference proceedings and other relevant documents were searched in MEDLINE, PubMed, PubMed Central and Google Scholar. Specifi

One Health for Dog-mediated Rabies Elimination in Asia. A Collection of Local Experiences

Although an effective human rabies vaccine has existed since 1885, rabies continues to kill an estimated 59,000 people every year. Sixty per cent of these human deaths occur in Asia. The number of animals, especially dogs, who die of rabies is uncalculated. To work towards the global target of eliminating dog-mediated human rabies deaths, the rabies community is applying the One Health approach by jointly focusing on humans and dogs. Written by a multidisciplinary group of scholars and rabies control programme specialists, this book is a collection of experiences and observations on the challenges and successes along the path to rabies control and prevention in Asia. The book: grounds chapters in solid scientific theory, but retains a direct, practice-focused and inspirational approach;provides numerous examples of lessons learned and experience-based knowledge gained across countries at different levels of rabies elimination;brings together and highlights the practices of a strong, international rabies network that works according to the One Health concept. Covering perspectives from almost a dozen Asian countries and a wide range of sectors and disciplines, such as healthcare facilities, veterinary services, laboratories, public health institutes, wildlife research centres and academia, this book is an invaluable resource for rabies practitioners and scholars, but also those working in the wider fields of disease control and cross-sectoral One Health