Recent Decisions

Comments on recent decisions by Joseph P. Summers, William J. Luff, Jr., Thomas Kavadas, Jr., Joseph A. Marino, James J. Harrington, Cornelius J. Collins, George P. McAndrews, Richard M. Bies, George A. Pelletier, Jr., Thomas M. Clusserath, and Rocco L. Puntureri

Recent Decisions

Comments on recent decisions by Lawrence J. Gallick, Joseph P. Summers, Thomas J. Kelly, Louis P. Pfeiler, and Hurley D. Smith

Recent Decisions

Comments on recent decisions by Cornelius F. Collins, Joseph P. Summers, Michael E. Phenner, Daniel J. Manelli, Ralph H. Witt, Richard C. Wilbur, and Raymond W. Brown

Theoretical investigation of positional influence of FBG sensors for structural health monitoring of offshore structures.

Fibre Bragg Grating (FBG) is a key technology for condition monitoring of different offshore oil and gas structures. FBG sensors are used to sense different physical parameters such as strain, temperature, vibration, etc. This paper investigates the effect of FBG sensor positions on the reflected sensing signal, to optimise the sensor positioning plan for structural health monitoring of offshore structures. Theoretical investigations were carried out on a cantilever beam to analyze the strain effects. Effect of different cantilever beam shapes, materials and their thickness on strain was investigated. Theoretical studies were also carried out to evaluate the strain sensitivities of FBG sensors. Furthermore, micrometer displacement based strain analysis of cantilever beam was carried out using FBG sensors and electrical strain gauges to study the positional influence and compared it with the theoretical results obtained

Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers

The encapsulation and selective delivery of therapeutic compounds within polymeric nanoparticles offers hope for the treatment of a variety of diseases. Traditional approaches to trigger selective cargo release typically rely on polymer degradation which is not always sensitive to the biological location of a material. In this report, we prepare nanoparticles from thermoresponsive polymers with a ‘solubility release catch’ at the chain-end. This release catch is exclusively activated in the presence of intracellular glutathione, triggering an ‘isothermal’ response and promoting a change in polymer solubility. This solubility switch leads to specific and rapid nanoparticle disassembly, release of encapsulated cargo and produces completely soluble polymeric side-products

Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs.

Herein, we report on naturally derived microtubule stabilizers with activity against triple negative breast cancer (TNBC) cell lines, including paclitaxel, fijianolide B/laulimalide (3), fijianolide B di-acetate (4), and two new semisynthetic analogs of 3, which include fijianolide J (5) and fijianolide L (6). Similar to paclitaxel, compound 3 demonstrated classic microtubule stabilizing activity with potent (GI50 = 0.7–17 nM) antiproliferative efficacy among the five molecularly distinct TNBC cell lines. Alternatively, compounds 5 or 6, generated from oxidation of C-20 or C-15 and C-20 respectively, resulted in a unique profile with reduced potency (GI50 = 4–9 μM), but improved efficacy in some lines, suggesting a distinct mechanism of action. The C-15, C-20 di-acetate, and dioxo modifications on 4 and 6 resulted in compounds devoid of classic microtubule stabilizing activity in biochemical assays. While 4 also had no detectable effect on cellular microtubules, 6 promoted a reorganization of the cytoskeleton resulting in an accumulation of microtubules at the cell periphery. Compound 5, with a single C-20 oxo substitution, displayed a mixed phenotype, sharing properties of 3 and 6. These results demonstrate the importance of the C-15/C-20 chiral centers, which appear to be required for the potent microtubule stabilizing activity of this chemotype and that oxidation of these sites promotes unanticipated cytoskeletal alterations that are distinct from classic microtubule stabilization, likely through a distinct mechanism of action

The Grizzly, February 28, 2002

Doug Farah Pays a Visit to Ursinus • Ursinus Students in Who\u27s Who List • Mysterious Rash Hits School Children Across the Country • Welcome to the Real World • Xanax Abuse • Controversy in the World of Figure Skating • Opinions: Spring Break; Sprinklers: Where are They?; Italy for a Semester • Experience the Beauty of Spring at the Philadelphia Flower Show • Marisol: A Different but Successful Performance at Ursinus College • Some Hot Tips for an Exciting and Safe Spring Break in Sunny Mexico • Track Team\u27s Results from Haverford • Men\u27s Basketball Falls Short at F&M • Men\u27s Rugby Team Admitted to Eastern Pennsylvania Rugby Union • Kings of the Court • Aivazian says Bye, Bye, Bye to the Division I Competition at UPenn • UC Swimmers Turn Up the Heat in the Water at the 2002 CC Championship Meethttps://digitalcommons.ursinus.edu/grizzlynews/1509/thumbnail.jp

The Grizzly, February 14, 2002

Salt Lake City Says Hello to the 2002 Winter Olympics • Black History Month at Ursinus: How Diverse is the Campus? • Lorelei: Blast or Bust? • All About Enron: Latest in the Scandal • Parking on Campus: Will There be Enough? • Opinions: Is the Bookstore Slighting Us?; New Dance Studio Missing One Thing: Dancers; Women Drinking While Pregnant: Is That Acceptable? • Exclusive Interview with Jamie Kennedy, Host of The Jamie Kennedy Experiment • The Silver-Brown Dance Company Stomps the Night Away • Is Digital TV Coming to Your House? • Introducing the Wellness Center • Black History Month at Ursinus: The Truth • What the Class of 2002 can Expect in the Real World • UC Women\u27s B-Ball Chops Down Washington on Friday, but Kneels to Swarthmore on Sunday • Ursinus Seeks Women\u27s Golf Coach and Prospective Players • UC Invitational Huge Success for Bears • Men\u27s Basketball Clinches Play-off Berth With Two Dominating Wins! • UC Bears Make a Splash in the Pool, Being Out-Touched by a Strong Bryn Mawr Teamhttps://digitalcommons.ursinus.edu/grizzlynews/1507/thumbnail.jp