Premotor-Motor interhemispheric inhibition is released during movement initiation in older but not young adults

Neural interactions between contralateral motor regions are thought to be instrumental in the successful preparation, and execution, of volitional movements. Here we investigated whether healthy ageing is associated with a change in functional connectivity, as indicated by the ability to modulate interhemispheric interactions during movement preparation in a manner that assists rapid movement responses. Thirteen young (mean age 22.2 years) and thirteen older (68.5 years) adults rapidly abducted their left index finger as soon as possible in response to a visual imperative signal, presented 500 ms after a visual warning signal. Interactions between left dorsal premotor cortex (LPMd) and right primary motor cortex (RM1) and between left primary motor cortex (LM1) and RM1 were investigated at six time points between the warning signal and the volitional response using paired-pulse transcranial magnetic stimulation. Relative to the inhibitory interactions measured at rest, both young and older adults released LM1-RM1 inhibition beginning 250 ms after the warning signal, with no significant differences between groups. LPMd-RM1 interactions became facilitatory (from the onset of the imperative signal onwards) in the older, but not the young, group. Regression analyses revealed that for the older adults, modulation of LPMd-RM1 interactions early in the preparation period was associated with faster responses, suggesting that specifically timed modulation of these pathways may be a compensatory mechanism to offset, at least in part, slowing of motor responses. The results suggest a greater reliance on premotor regions during the preparation of simple motor actions with advancing age

Age-related differences in corticomotor excitability and inhibitory processes during a visuomotor RT task

This study tested the postulation that change in the ability to modulate corticospinal excitability and inhibitory processes underlie age-related differences in response preparation and generation during tasks requiring either rapid execution of a motor action or actively withholding that same action. Younger (n = 13, mean age = 26.0 years) and older adults (n = 13, mean age = 65.5 years) performed an RT task in which a warning signal (WS) was followed by an imperative signal (IS) to which participants were required to respond with a rapid flexion of the right thumb (go condition) or withhold their response (no-go condition). We explored the neural correlates of response preparation, generation, and inhibition using single- and paired-pulse TMS, which was administered at various times between WS and IS (response preparation phase) and between IS and onset of response-related muscle activity in the right thumb (response generation phase). Both groups exhibited increases in motor-evoked potential amplitudes (relative to WS onset) during response generation; however, this increase began earlier and was more pronounced for the younger adults in the go condition. Moreover, younger adults showed a general decrease in short-interval intracortical inhibition during response preparation in both the go and no-go conditions, which was not observed in older adults. Importantly, correlation analysis suggested that for older adults the task-related increases of corticospinal excitability and intracortical inhibition were associated with faster RT. We propose that the declined ability to functionally modulate corticospinal activity with advancing age may underlie response slowing in older adults

Association of Oral Disease with 12 Selected Variables: I. Periodontal Disease

The association of periodontal disease with 12 selected variables, considered to be intrinsic-systemic factors, was examined. A probability sample of 324 subjects, ≥ 20 years old, was studied. The statistical analyses included simple, partial, and multiple correlations, and linear regression.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66595/2/10.1177_00220345680470031901.pd

Vacuum Fluctuations, Geometric Modular Action and Relativistic Quantum Information Theory

A summary of some lines of ideas leading to model-independent frameworks of relativistic quantum field theory is given. It is followed by a discussion of the Reeh-Schlieder theorem and geometric modular action of Tomita-Takesaki modular objects associated with the quantum field vacuum state and certain algebras of observables. The distillability concept, which is significant in specifying useful entanglement in quantum information theory, is discussed within the setting of general relativistic quantum field theory.Comment: 26 pages. Contribution for the Proceedings of a Conference on Special Relativity held at Potsdam, 200

Haag duality and the distal split property for cones in the toric code

We prove that Haag duality holds for cones in the toric code model. That is, for a cone Lambda, the algebra R_Lambda of observables localized in Lambda and the algebra R_{Lambda^c} of observables localized in the complement Lambda^c generate each other's commutant as von Neumann algebras. Moreover, we show that the distal split property holds: if Lambda_1 \subset Lambda_2 are two cones whose boundaries are well separated, there is a Type I factor N such that R_{Lambda_1} \subset N \subset R_{Lambda_2}. We demonstrate this by explicitly constructing N.Comment: 15 pages, 2 figures, v2: extended introductio

Bondi-Metzner-Sachs symmetry, holography on null-surfaces and area proportionality of "light-slice" entropy

It is shown that certain kinds of behavior, which hitherto were expected to be characteristic for classical gravity and quantum field theory in curved spacetime, as the infinite dimensional Bondi-Metzner-Sachs symmetry, holography on event horizons and an area proportionality of entropy, have in fact an unnoticed presence in Minkowski QFT. This casts new light on the fundamental question whether the volume propotionality of heat bath entropy and the (logarithmically corrected) dimensionless area law obeyed by localization-induced thermal behavior are different geometric parametrizations which share a common primordeal algebraic origin. Strong arguments are presented that these two different thermal manifestations can be directly related, this is in fact the main aim of this paper. It will be demonstrated that QFT beyond the Lagrangian quantization setting receives crucial new impulses from holography onto horizons. The present paper is part of a project aimed at elucidating the enormous physical range of "modular localization". The latter does not only extend from standard Hamitonian heat bath thermal states to thermal aspects of causal- or event- horizons addressed in this paper. It also includes the recent understanding of the crossing property of formfactors whose intriguing similarity with thermal properties was, although sometimes noticed, only sufficiently understood in the modular llocalization setting.Comment: 42 pages, changes, addition of new results and new references, in this form the paper will appear in Foundations of Physic

Greater numbers of antral follicles in the ovary are associated with increased concentrations of glucose in uterine luminal fluid of beef heifers

Increased antral follicles are associated with greater fertility and a uterine environment that is more supportive of early embryonic development in beef heifers. Glucose is a primary energy source for embryos, and glucose concentrations are elevated in uterine luminal fluid (ULF) of pregnant heifers. We hypothesized that ULF glucose concentrations and endometrial transcript abundance for glucose transporters on d16 after insemination would be greater in heifers with increased numbers of antral follicles. Heifers classified with either increased or diminished antral follicle counts were artificially inseminated following the CO-Synch protocol (d0). On d16 after insemination, reproductive tracts of heifers were collected at an abattoir to retrieve conceptuses to determine pregnancy. Uterine luminal fluid was collected, endometrium was biopsied, total RNA was extracted and glucose transporter transcript abundances were determined. Data were analyzed using the MIXED procedure of SAS with antral follicle group, pregnancy status, and the interaction as fixed effects. Glucose concentrations in ULF were greater in heifers with increased antral follicle numbers. Glucose ULF concentrations increased in pregnant heifers. Facilitated glucose transporter member 1 (SLC2A1) transcript abundance was increased in the endometrium of pregnant heifers but was not different due to antral follicle number or the interaction. Differences in uterine concentrations of glucose associated with antral follicle number could be due to another mechanism, since glucose transporters were not different between antral follicle numbers. Therefore, heifers with increased number of antral follicles have increased energy availability in the uterus to support trophoblast proliferation and function

Differential cross sections, charge production asymmetry, and spin-density matrix elements for D*(2010) produced in 500 GeV/c pi^- nucleon interactions

We report differential cross sections for the production of D*(2010) produced in 500 GeV/c pi^- nucleon interactions from experiment E791 at Fermilab, as functions of Feynman-x (x_F) and transverse momentum squared (p_T^2). We also report the D* +/- charge asymmetry and spin-density matrix elements as functions of these variables. Investigation of the spin-density matrix elements shows no evidence of polarization. The average values of the spin alignment are \eta= 0.01 +- 0.02 and -0.01 +- 0.02 for leading and non-leading particles, respectively.Comment: LaTeX2e (elsart.cls). 13 pages, 6 figures (eps files). Submitted to Physics Letters

Asymmetries between the production of D+ and D- mesons from 500 GeV/c pi- nucleon interactions as a function of xF and pt**2

We present asymmetries between the production of D+ and D- mesons in Fermilab experiment E791 as a function of xF and pt**2. The data used here consist of 74,000 fully-reconstructed charmed mesons produced by a 500 GeV/c pi- beam on C and Pt foils. The measurements are compared to results of models which predict differences between the production of heavy-quark mesons that have a light quark in common with the beam (leading particles) and those that do not (non-leading particles). While the default models do not agree with our data, we can reach agreement with one of them, PYTHIA, by making a limited number of changes to parameters used