Comparative Analysis of Fractal Properties of Solar Faculae

Present study is aimed at investigating the solar faculae area from 1990 to 2007 which partially covered the22nd and 23rd solar cycle. Rescaled Range Analysis (RRA) and Detrended Fluctuation Analysis (DFA) have beenadopted to evaluate the behaviour of nonlinear dynamics of solar faculae area. Results show that the value of Hurstexponent for solar faculae area from RRA and DFA is negatively correlated. It means it is non-persistent and longrange correlated. Obtained result is inaccurate so the only solution is to transform the data into stationary data by takingdifferencing. RRA is applied on residuals and RRA to evaluate the fractal property of the time series. Solar faculae areainvestigated in this study is fractal in nature and predictable ass well. Moreover, the time series of solar faculae area isnon-linear as established by the Brock – Dechert – Scheinkman (BDS) test result

Estimation of Absolute Speed of Vehicle with the Simplified Inverse Model

Presently the calculations of complete speed of railway vehicles are very useful for the people in Pakistan. This is obtained by observing the stimulated time shift for the arbitrary track between two wheel sets of a bogie. The model developed in this research work is aimed to collect specific characteristics of the movements at the wheel sets via two inertial sensors seated onto a bogie. An input in the system is provided by means of the rough surface of track that produces bounce in both wheels that is identical except in the delay of time. This delay of time is detected by the space between the two wheels. The cross-correlation calculation technique has been used to determine the delay in time between the movements from one to another. The calculating method is achieved by extraction, which is based on a discursive model of vehicle

Can serial monitoring of serum Vascular Endothelial Growth Factor (VEGF), Nitric Oxide (NO), and Angiotensin II (ANGII) levels have predictive role during Bevacizumab treatment?

Background: Standard treatment of colorectal cancer includes both cytostatic chemotherapy and targeted therapies. Bevacizumab, targeting the VEGF receptor, is one of the primary targeted therapies that achieve better response rate and survival rate as compared to combination chemotherapy. To the best of our knowledge, there is no established single marker that can be used as a predictive marker in bevacizumab therapy. Material/Methods: We enrolled 24 patients with the diagnosis of metastatic colorectal cancer in our study. During the study, 2 blood samples were drawn from patients before the first cycle and after the sixth cycle of bevacizumab therapy. Serum levels of VEGF, ANG II, and NO were recorded. Results: While the change across VEGF levels was found to be a statistically significant decreasing trend (p=0.009), this decrease was not found to be correlated with treatment response and hypertension development. Additionally, no statistically significant difference was found in terms of NO and ANG II levels. Conclusions: This study showed a significant decrease in serum VEGF, but failed to show a significant change in NO and ANG II levels during bevacizumab treatment. Although no significant correlation was found between the presence of hypertension and markers, most patients (83%) had an increase in their blood pressure. Our results suggest that dynamic monitoring of NO and ANG II, along with VEGF, may not be useful as predictive markers for bevacizumab treatment in colorectal cancer