Design, fabrication, and test of a steel spar wind turbine blade

The design and fabrication of wind turbine blades based on 60 foot steel spars are discussed. Performance and blade load information is given and compared to analytical prediction. In addition, performance is compared to that of the original MOD-O aluminum blades. Costs for building the two blades are given, and a projection is made for the cost in mass production. Design improvements to reduce weight and improve fatigue life are suggested

Missing heavy flavor backgrounds to Higgs boson production

We investigate characteristics of the signal and backgrounds for Higgs boson decay into WW at the Fermilab Tevatron and CERN Large Hadron Collider. In the the lepton-pair-plus-missing-energy final state, we show that the background receives an important contribution from semileptonic decays of heavy flavors. Lepton isolation cuts provide too little suppression of these heavy flavor contributions, and an additional 4 to 8 orders-of-magnitude suppression must come from physics cuts. We demonstrate that an increase of the minimum transverse momentum of nonleading leptons in multilepton events is one effective way to achieve the needed suppression, without appreciable loss of the Higgs boson signal. Such a cut would impact the efficiency of searches for supersymmetry as well. We emphasize the importance of direct measurement of the lepton background from heavy flavor production.Comment: 23 pgs., 10 figs, revtex4, 1 Ref. added, minor typos corrected, to appear in Phys. Rev.

Theoretical Characterization of the Interface in a Nonequilibrium Lattice System

The influence of nonequilibrium bulk conditions on the properties of the interfaces exhibited by a kinetic Ising--like model system with nonequilibrium steady states is studied. The system is maintained out of equilibrium by perturbing the familiar spin--flip dynamics at temperature T with completely--random flips; one may interpret these as ideally simulating some (dynamic) impurities. We find evidence that, in the present case, the nonequilibrium mechanism adds to the basic thermal one resulting on a renormalization of microscopic parameters such as the probability of interfacial broken bonds. On this assumption, we develop theory for the nonequilibrium "surface tension", which happens to show a non--monotonous behavior with a maximum at some finite T. It ensues, in full agreement with Monte Carlo simulations, that interface fluctuations differ qualitatively from the equilibrium case, e.g., the interface remains rough at zero--T. We discuss on some consequences of these facts for nucleation theory, and make some explicit predictions concerning the nonequilibrium droplet structure.Comment: 10 pages, 7 figures, submitted to Phys. Re

Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis

Peer reviewedPublisher PD

Variation in the CENP-A sequence association landscape across diverse inbred mouse strains.

Centromeres are crucial for chromosome segregation, but their underlying sequences evolve rapidly, imposing strong selection for compensatory changes in centromere-associated kinetochore proteins to assure the stability of genome transmission. While this co-evolution is well documented between species, it remains unknown whether population-level centromere diversity leads to functional differences in kinetochore protein association. Mice (Mus musculus) exhibit remarkable variation in centromere size and sequence, but the amino acid sequence of the kinetochore protein CENP-A is conserved. Here, we apply k-mer-based analyses to CENP-A chromatin profiling data from diverse inbred mouse strains to investigate the interplay between centromere variation and kinetochore protein sequence association. We show that centromere sequence diversity is associated with strain-level differences in both CENP-A positioning and sequence preference along the mouse core centromere satellite. Our findings reveal intraspecies sequence-dependent differences in CENP-A/centromere association and open additional perspectives for understanding centromere-mediated variation in genome stability