Integrated genomic characterization of pancreatic ductal adenocarcinoma

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine

Drawing the landscape : the art of hand drawing and digital representation

xiv, 338 p. : ill. ; 27.5 c

Drawing the landscape

iv,326hlm.;bib.;ill.;indek

Illustrated history of landscape design / Elizabeth Boults and Chip Sullivan.

Includes bibliographical references and index.Book Fair 2013.xi, 260 p. :"Illustrated History of Landscape Design takes an optical sweep of the iconic landscapes constructed throughout the ages. Organized by century and geographic region, this highly visual reference uses hundreds of masterful pen-and-ink drawings to show how historical context and cultural connections can illuminate today's design possibilities. This guide includes: Storyboards, case studies, and visual narratives to portray spaces; Plan, section, and elevation drawings of key spaces; Summaries of design concepts, principles, and vocabularies; Historic and contemporary works of art that illuminate a specific era; and Descriptions of how the landscape has been shaped over time in response to human need." "Directing both students and practitioners along a visually stimulating timeline, Illustrated History of Landscape Design is a valuable educational tool as well as an endless source of inspiration."--BOOK JACKET

Capp Street Project, 1989-1990

Levi Strauss discusses the nine American artists who participated in the San Francisco-based artists-in-residence program in 1989 and 1990. Includes documentation on eight experimental projects and works-in-progress. Artist's statements. Biographical notes