Gugatan akidah: reda dengan kekafiran

Tajuk yang dibincangkan dalam penulisan ini ialah mengenai perkara yang boleh merosakkan akidah seseorang Muslim sama ada dalam sedar atau tidak sedar. Selain itu reda dengan kekafiran ialah menerima sesuatu dengan hati terbuka dan mengizinkan kepada sesuatu itu untuk berlaku tanpa ada persoalan. Meredakan sesuatu perkara sama ada yang baik atau buruk dalam situasi yang tertentu. Seterusnya, kafir pula dimaksudkan dalam bahasa Arab kafir bermaksud orang yang menyembunyikan atau mengingkari kebenaran dalam sesuatu keadaaan. Kafir juga digunakan kepada orang Islam yang mengingkari nikmat Allah. Reda dengan kekafiran boleh dijatuhkan kepada kekafiran dalam dua bentuk keadaan. Pertama ialah tidak mengkafirkan orang kafir. Kedua, tidak mengkafirkan orang Islam yang mengikuti upacara ibadat fahaman yang bukan Islam

Humanitarian Logistics and Its Challenges: The Literature Review

This study demonstrates the importance of humanitarian logistics as a fields that need an attention by everyone. With the unstable of climate condition, it can be seen that many disaster has happened around the world. The 2011 incidents that strike the develop nation, Japan, has shock the world and teach every country to be better prepared of any unexpected event. The objective of this study is to highlight the challenges in humanitarian logistics process in met the objective relief. Keywords humanitarian, logistics, challenges

Impact of Political, Social Safety, and Legal Risks and Host Country Attitude towards Foreigners on Project Performance of China Pakistan Economic Corridor (CPEC)

The China Pakistan Economic Corridor (CPEC) project was signed between China and Pakistan in the year 2013. This mega project connects the two countries to enhance their economic ties and give them access to international markets. The initial investment for the project was $46 billion with a tentative duration of fifteen years. Being an extensive project in terms of cost and duration, many factors and risks affect its performance. This study aims to investigate the effects of political (PR), social safety (SR), and legal risks (LR) on the project performance (PP) of the CPEC. It further investigates the significance of the host country’s attitude towards foreigners (HCA). A research framework consisting of PR, SR, and LR as independent variables, PP as the dependent variable, and HCA as moderator is formulated and tested in the current study. In this quantitative study, the Likert scale is used to measure the impact of the assessed risks. A questionnaire survey is used as a data collection tool to collect data and test the research framework and associated hypotheses. The partial least square structural equation modeling (PLS-SEM) is used to perform the empirical test for validation of the study, with a dataset of 99 responses. The empirical investigation finds a negative relationship between PR, SR, LR, and PP. It is concluded that PR, SR, and LR negatively influence the PP of CPEC. Furthermore, HCA negatively moderates the PR, LR, and PP of CPEC. In contrast, the value of SR and PP is positive in the presence of the positive HCA

Enhanced recovery programmes for lower limb arthroplasty in the UK

Introduction: Enhanced recovery programmes (ERPs) reduce patient morbidity and mortality, and provide significant cost savings by reducing length of stay. Currently, no uniform ERP guidelines exist for lower limb arthroplasty in the UK. The aim of this study was to identify variations in ERPs and determine adherence to local policy. Methods: Hospitals offering elective total knee arthroplasty (TKA) and total hip arthroplasty (THA) (23 and 22 centres respectively) contributed details of their ERPs, and performed an audit (15 patients per centre) to assess compliance. Results: Contrasting content and detail of ERPs was noted across centres. Adherence to ERPs varied significantly (40–100% for TKA, 17–94% for THA). Analysis identified perioperative use of dexamethasone, tranexamic acid and early mobilisation for TKA, and procedures performed in teaching hospitals for THA as being associated with a reduced length of stay. Conclusions: This study highlights variation in practice and poor compliance with local ERPs. Given the proven benefits of ERPs, evidence-based guidelines in the context of local skillsets should be established to optimise the patient care pathway

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study

Objective To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. Patients and Methods This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries. Results Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001). Conclusions A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Lithological mapping of northern Kohat Plateau’s limestone outcrops using integrated remote sensing and reflectance spectroscopy techniques

ABSTRACTRemote sensing (RS) has emerged as a valuable technology for precisely demarcating the extent of lithological units in rugged terrains. It offers valuable insights into the spatial distribution and structural dynamics of complex topographies. In this study, RS technology manifested by Sentinel-2A and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) imagery is used to discriminate carbonaceous strata in various parts of the Kohat Plateau region, northwest Pakistan. Various spectral image transformation techniques, including principal component analysis (PCA), minimum noise fraction (MNF), band ratio (BR), and carbonate index (CI), were utilized after atmospheric correction modules. The resultant red-green-blue (RGB) color composites obtained from Sentinel-2A, incorporating PCA (PC1, PC2, PC4) and MNF (MNF1, MNF2, MNF3), demonstrated its applicability to accurately discriminate the target features. The derived RGB color composites from the BR on ASTER data (BR5/1, BR5/7, BR3/4 × 5/4) and CI B13/B14 effectively identified the limestone bodies, providing a better approach to differentiate limestone from other lithological units. Also, the integration of spectroscopic field data with satellite-based resultant images represented a meaningful contribution to rectifying previous geological maps. The derived maps from aforementioned techniques exhibited a notable attribute to record the target units and enhance limestone differentiation from other lithologies