5 research outputs found
Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial
Background Excess visceral adiposity is associated with increased risk of cardiometabolic disorders. Shortâterm wellâcontrolled clinical trials suggest that regular avocado consumption favorably affects body weight, visceral adiposity, and satiety. Methods and Results The HAT Trial (Habitual Diet and Avocado Trial) was a multicenter, randomized, controlled parallelâarm trial designed to test whether consuming 1 large avocado per day for 6âmonths in a diverse group of freeâliving individuals (N=1008) with an elevated waist circumference compared with a habitual diet would decrease visceral adiposity as measured by magnetic resonance imaging. Secondary and additional end points related to risk factors associated with cardiometabolic disorders were assessed. The primary outcome, change in visceral adipose tissue volume during the intervention period, was not significantly different between the Avocado Supplemented and Habitual Diet Groups (estimated mean difference (0.017âL [â0.024âL, 0.058âL], P=0.405). No significant group differences were observed for the secondary outcomes of hepatic fat fraction, hsCRP (highâsensitivity Câreactive protein), and components of the metabolic syndrome. Of the additional outcome measures, modest but nominally significant reductions in total and lowâdensity lipoprotein cholesterol were observed in the Avocado Supplemented compared with the Habitual Diet Group. Changes in the other additional and post hoc measures (body weight, body mass index, insulin, very lowâdensity lipoprotein concentrations, and total cholesterol:highâdensity lipoprotein cholesterol ratio) were similar between the 2 groups. Conclusions Addition of 1 avocado per day to the habitual diet for 6âmonths in freeâliving individuals with elevated waist circumference did not reduce visceral adipose tissue volume and had minimal effect on risk factors associated with cardiometabolic disorders. Registration URL: https://clinicaltrials.gov; Unique identifier: NCT03528031