High Dynamic Pixel Structure Based on an Adaptive Integrating Capacitor

Infrared image sensing technology has received widespread attention due to its advantages of not being affected by the environment, good target recognition, and high anti-interference ability. However, with the improvement of the integration of the infrared focal plane, the dynamic range of the photoelectric system is difficult to improve, that is, the restrictive trade-off between noise and full well capacity is particularly prominent. Since the capacitance of the inversion MOS capacitor changes with the gate–source voltage adaptively, the inversion MOS capacitor is used as the capacitor in the infrared pixel circuit, which can solve the contradiction between noise in low light and full well capacity in high light. To this end, a highly dynamic pixel structure based on adaptive capacitance is proposed, so that the capacitance of the infrared image sensor can automatically change from 6.5 fF to 37.5 fF as the light intensity increases. And based on 55 nm CMOS process technology, the performance parameters of an infrared image sensor with a 12,288 × 12,288 pixel array are studied. The research results show that a small-size pixel of 5.5 µm × 5.5 µm has a large full well capacity of 1.31 Me− and a variable conversion gain, with a noise of less than 0.43 e− and a dynamic range of more than 130 dB

High-Linearity and High-Speed ROIC of Ultra-Large Array Infrared Detectors Based on Adaptive Compensation and Enhancement

In order to solve the problem of limited linearity and frame rate in the large array infrared (IR) readout integrated circuit (ROIC), a high-linearity and high-speed readout method based on adaptive offset compensation and alternating current (AC) enhancement is proposed in this paper. The efficient correlated double sampling (CDS) method in pixels is used to optimize the noise characteristics of the ROIC and output CDS voltage to the column bus. An AC enhancement method is proposed to quickly establish the column bus signal, and an adaptive offset compensation method is used at the column bus terminal to eliminate the nonlinearity caused by the pixel source follower (SF). Based on the 55 nm process, the proposed method is comprehensively verified in an 8192 × 8192 IR ROIC. The results show that, compared with the traditional readout circuit, the output swing is increased from 2 V to 3.3 V, and the full well capacity is increased from 4.3 Me- to 6 Me-. The row time of the ROIC is reduced from 20 µs to 2 µs, and the linearity is improved from 96.9% to 99.98%. The overall power consumption of the chip is 1.6 W, and the single-column power consumption of the readout optimization circuit is 33 μW in the accelerated readout mode and 16.5 μW in the nonlinear correction mode

DSphere: A Source-Centric Approach to Crawling, Indexing and Searching the World Wide Web

We describe DSPHERE 1 − a decentralized system for crawling, indexing, searching and ranking of documents in the World Wide Web. Unlike most of the existing search technologies that depend heavily on a page-centric view of the Web, we advocate a source-centric view of the Web and propose a decentralized architecture for crawling, indexing and searching the Web in a distributed source-specific fashion. A fully decentralized crawler is developed to crawl the World Wide Web where each peer is assigned the responsibility of crawling a specific set of documents referred to as a source collection. Link analysis techniques are used for ranking documents. Traditional link analysis techniques suffer from problems like slow refresh rate and vulnerabilities to Web Spam, to counter which, we propose a source-based link analysis algorithm which computes fast and accurate ranking scores for all crawled documents. 1

Highly Flexible Indium Tin Oxide Nanofiber Transparent Electrodes by Blow Spinning

Transparent conductive film (TCF) has found wide applications. Indium tin oxide (ITO) is currently the most widely used transparent electrode. However, major problem of ITO is the lacking of flexibility, which totally limits its applications. Here, we report a highly flexible transparent electrode consisting of freestanding ITO nanofiber network fabricated by blow spinning, the advantage of which is its high-efficiency, low cost and safety. When the bending radius decreased to 0.5 mm, the resistance of the transparent electrodes only increased by 18.4%. Furthermore, the resistance was almost unchanged after thousands of bending cycles at 3.5 mm bending radius

Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor

For a subpopulation of acute myeloid leukemia (AML) patients, the mutationally activated tyrosine kinase FLT3, has emerged as a promising target for therapy. The development of drug resistance due to mutation is a growing concern for mutant FLT3 inhibitors, such as PKC412, Quizartinib, PLX3397, and Crenolanib. Thus, there is a need to develop novel FLT3 inhibitors that overcome these mutations. Here we report the development of a novel type I ATP competitive inhibitor, JH-IX-179, that is extremely potent and selective for FLT3. JH-IX-179 also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases. The unique and specific kinase inhibition profile suggests that this chemotype may represent an attractive starting point for the development of further improved FLT3 inhibitors with therapeutic potential in tumors harboring deregulated FLT3 activity

Continuous Draw Spinning of Extra-Long Silver Submicron Fibers with Micrometer Patterning Capability

Ultrathin metal fibers can serve as highly conducting and flexible current and heat transport channels, which are essential for numerous applications ranging from flexible electronics to energy conversion. Although industrial production of metal fibers with diameters of down to 2 μm is feasible, continuous production of high-quality and low-cost nanoscale metal wires is still challenging. Herein, we report the continuous draw spinning of highly conductive silver submicron fibers with the minimum diameter of ∼200 nm and length of more than kilometers. We obtained individual AgNO₃/polymer fibers by continuous drawing from an aqueous solution at a speed of up to 8 m/s. With subsequent heat treatment, freestanding Ag submicron fibers with high mechanical flexibility and electric conductivity have been obtained. Woven mats of aligned Ag submicron fibers were used as transparent electrodes with high flexibility and high performance with sheet resistance of 7 Ω sq^–1 at a transparency of 96%. Continuous draw spinning opened new avenues for scalable, flexible, and ultralow-cost fabrication of extra-long conductive ultrathin metal fibers