Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of reserpine in rodents induces motor impairments that are accompanied by cognitive deficits, and has been applied to model both tardive dyskinesia and Parkinson's disease. The present study investigated whether CBD administration would attenuate reserpine-induced motor and cognitive impairments in rats. Male Wistar rats received four injections of CBD (0.5 or 5 mg/kg) or vehicle (days 2-5). On days 3 and 5, animals received also one injection of 1 mg/kg reserpine or vehicle. Locomotor activity, vacuous chewing movements, and catalepsy were assessed from day 1 to day 7. On days 8 and 9, we evaluated animals' performance on the plus-maze discriminative avoidance task, for learning/memory assessment. CBD (0.5 and 5 mg/kg) attenuated the increase in catalepsy behavior and in oral movements - but not the decrease in locomotion induced by reserpine. CBD (0.5 mg/kg) also ameliorated the reserpine-induced memory deficit in the discriminative avoidance task. Our data show that CBD is able to attenuate motor and cognitive impairments induced by reserpine, suggesting the use of this compound in the pharmacotherapy of Parkinson's disease and tardive dyskinesia.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Sao Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, BrazilUniv Sao Paulo, Dept Neurosci & Behav, Ribeirao Preto, BrazilNatl Council Sci & Technol Dev, Natl Inst Translat Med, Ribeirao Preto, BrazilInterdisciplinary Laboratory of Clinical Neurosciences, Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilDepartment of Pharmacology, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilFAPESP: 2010/07994-3FAPESP: 2015/03354-3CNPq/MS/SCTIE/DECIT: 26/2014CNPq/MS/SCTIE/DECIT: 466805/2014-4Web of Scienc

Peripubertal treatment with cannabidiol prevents the emergence of psychosis in an animal model of schizophrenia

Fed Univ Sao Paulo UNIFESP EPM, Dept Psychiat, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP EPM, Dept Pharmacol, Sao Paulo, BrazilUniv Sao Paulo, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, BrazilCNPq, Natl Inst Translat Med INCT TM, Ribeirao Preto, BrazilFed Univ Sao Paulo UNIFESP EPM, Dept Psychiat, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP EPM, Dept Pharmacol, Sao Paulo, BrazilWeb of Scienc