Quality of life of children with neurodevelopmental disorders and their parents during the COVID-19 pandemic : a 1-year follow-up study

This study aimed to reveal changes in the quality of life (QOL) of children with neurodevelopmental disorders and their parents, and the interaction between their QOL and parental mental state during the coronavirus 2019 (COVID-19) pandemic. Eighty-nine school-aged children and parents participated in surveys in May 2020 (T1) and May 2021 (T2). The parents completed questionnaires that assessed their QOL, depression, parenting stress, and living conditions. Children's temporary mood status was evaluated using the self-reported visual analog scale (VAS). Children's QOL and VAS at T2 were higher than their QOL at T1. Parents' QOL at T2 was lower than their QOL at T1. Severe parental depression at T1 had a synergistic effect on severe parenting stress and severe depressive state at T2. Additionally, children's high QOL at T1 had a synergistic effect on low parenting stress and children's high QOL at T2. Furthermore, children's low VAS scores and parents' low QOL at T2 were associated with deterioration of family economic status. Children and parents' QOL changed during the prolonged COVID-19 pandemic. Improvement in children's QOL was influenced by reduced maternal depressive symptoms. Public support for parental mental health is important to avoid decreasing QOL.Peer reviewe

A vivência do contexto domiciliar por familiares e profissionais de saúde

Aim: to understand the experience of the home context in the perspective of family caregivers and health professionals and to present a theoretical model that represents this experience. Methods: the Data-Based Theory was developed in a Home Care Service. Data were collected from February to December 2016 using a semi-structured in-depth interview with 22 participants, who were divided into two sample groups. Results were analyzed according to the constant comparative method, revealing the significant theoretical coding. Results: the understanding of this phenomenon occurred through the following categories: Entering Home Care (cause); Interacting with the social support network (strategy); Expressing perceptions of one’s experience of care (intervening condition); and Experiencing home context aspects (consequence). Final considerations: the participants’ experience revealed that home care has its own context, including a cause, strategy, intervening condition and consequence, which must be taken into consideration by those involved with this type of care.Objetivos: comprender la vivencia en el contexto domiciliar desde la perspectiva de los familiares cuidadores y profesionales de la salud. Método: Teoría Fundamentada en Datos, desarrollada en Servicio de Atención Domiciliar, recolección de datos realizada entre febrero y diciembre de 2016, por medio de entrevista semi estructurada, con 22 participantes. Se analizó los resultados a partir del método comparativo constante, demostrando la codificación sustantiva y teórica. Resultados: la compresión del fenómeno fue realizada por medio de las categorías: ingresando en el cuidado domiciliar (causa); inter-relacionándose con la red social de apoyo (estrategia); expresando percepciones sobre la vivencia del cuidado (condición interviniente); experimentando aspectos del contexto domiciliar (consecuencia). Consideraciones finales: el fenómeno evidencia que la vivencia en el contexto domiciliar ocurre en función de las condiciones ambientales y físicas de la casa, que incluyen las condiciones de higiene y seguridad, de los aspectos socioeconómicos, de la relaciones y cultura de las familias y de los recursos disponibles para el cuidado de las redes sociales de apoyo.Objetivo: compreender a vivência do contexto domiciliar na perspectiva dos familiares cuidadores e profissionais de saúde. Método: Teoria Fundamentada em Dados desenvolvida em Serviço de Atendimento Domiciliar, coleta realizada de fevereiro a dezembro de 2016, por meio de entrevista semiestruturada, com 22 participantes divididos em dois grupos amostrais. Para a análise dos dados realizou-se codificação substantiva e teórica. Resultados: a compreensão do fenômeno se deu por meio das categorias: ingressando no cuidado domiciliar (causa); inter-relacionando-se com a rede social de apoio (estratégia); expressando percepções acerca da vivência do cuidado (condição interveniente) e experienciando aspectos do contexto domiciliar (consequência). Considerações finais: o fenômeno esclarece que a vivência do contexto domiciliar decorre das condições ambientais e físicas da casa que incluem as condições de higiene e segurança, dos aspectos socioeconômicos, relacionais e culturais das famílias e dos recursos disponíveis para o cuidado provenientes das redes sociais de apoio

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic

BACKGROUND: During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study\u27s objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines. METHODS: We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before (1 year and immediately before) and during the pandemic, defined as 1 March-31 May 2020. The prior 1-year control period (1 March-31 May 2019) was obtained to account for seasonal variation. FINDINGS: There was a significant decline in SAH hospitalisations, with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic, representing a relative decline of 22.5% (95% CI -24.3% to -20.7%, p\u3c0.0001). Embolisation of ruptured aneurysms declined with 1170-1035 procedures, respectively, representing an 11.5% (95%CI -13.5% to -9.8%, p=0.002) relative drop. Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations, a 24.9% relative decline (95% CI -28.0% to -22.1%, p\u3c0.0001). A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1% (95% CI 32.3% to 50.6%, p=0.008) despite a decrease in SAH admissions in this tertile. INTERPRETATION: There was a relative decrease in the volume of SAH hospitalisations, aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic. These findings in SAH are consistent with a decrease in other emergencies, such as stroke and myocardial infarction

A re-evaluation of the Mn-Cr systematics of olivine from the angrite meteorite D'Orbigny using secondary ion mass spectrometry

'Quenched' angrite meteorites are among the best time markers of igneous activity in early formed planetesimals of the Solar System. They can be precisely dated by the Mn-Cr extinct nuclide decay system because they contain olivine with high Mn/Cr. Never

Neutrophil infiltration and oxidant-production in human atherosclerotic carotid plaques

To clarify the clinical implications of neutrophils in vulnerable plaques we evaluated the function and activity of infiltrated neutrophils in an atherosclerotic plaque, focusing on oxidant production. A histopathological investigation was performed using carotid arterial samples obtained from seven patients. The atherosclerotic plaques were examined cytochemically for naphthol-ASD-chloroacetate esterase activity and oxidant-production, and immunohistochemically using N-formyl peptide receptor-like 1 (fPRL1)-, CD66b-, CD68- or p22phox-specific antibodies. The cytoplasmic fPRL1 intensity value of the neutrophils in the plaque was estimated using an activity index. Naphthol-ASD-chloroacetate esterase activity was found in cells located in the atherosclerotic plaque, indicating that the cells were neutrophils. The cytoplasmic fPRL1 intensity value of the neutrophils in the plaque decreased to approximately 60% of the intensity observed in the capillary vessels. Oxidantproduction was also detected in the plaques, and both neutrophils and macrophages were observed at the corresponding oxidant-production sites. p22phox expression was also located in the same areas in which oxidant-production was observed in these plaques. We could not directly evaluate how much ROS generated from the infiltrated neutrophils contributed the plaque vulnerability followed by its rupture. However, the infiltrated neutrophils in the atherosclerotic plaques morphologically appeared activated and were actively generating oxidant, implying that neutrophils, together with macrophages, infiltrate into atherosclerotic plaques and contribute to plaque vulnerability

Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study

Purpose: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year. Patients and methods: One hundred and seventy-two participants <20 years of age (mean age: 18.32 years, standard deviation: 0.50), who did not meet the full criteria for an MDE, were selected from 2, 494 screened freshmen based on the Beck Depression Inventory, 2nd edition (BDI-II). We conducted a cohort study of three groups (low-, middle-, and high-symptom groups) divided based on BDI-II scores, over a 1 year period with the use of bimonthly assessments. Temporal changes of depressive symptoms were analyzed using linear mixed modeling and growth mixture modeling. Results: First, we found that late adolescents with subthreshold depression (high depressive symptoms) were split between the increasing and decreasing depressive symptoms groups, whereas the majority of the less-symptoms group remained stable during 1 year. Second, in comparison with late adolescents with less depressive symptoms, those with subthreshold depression had an elevated risk of later depression. Conclusion: Some late adolescents with subthreshold depression had increased depressive symptoms and developed an MDE during 1 year. Therefore, it is necessary for us to rigorously assess the changes in subthreshold depressive symptoms over time in late adolescents

The quality of life of children with neurodevelopmental disorders and their parents during the Coronavirus disease 19 emergency in Japan

This study aimed to reveal how the COVID-19 stay-at-home period has affected the quality of life (QOL) of children with neurodevelopmental disorders and their parents and to identify possible factors that enabled them to maintain their QOL. We enrolled 136 school-aged children (intellectual quotient >= 50) and their parents and administered QOL questionnaires to assess the maladaptive behavior of the children; depression, anxiety, and stress of the parents; and activities of their daily lives. The relationship between their QOL and clinical features was examined. The decrease in QOL of children and parents was associated with the mother's limited job flexibility. Decreased QOL was also associated with changes in the sleep rhythms of the children. Maladaptive behaviors in children were associated with parental stress. However, maintained QOL of some families who faced these same conditions of job stress and sleep disorders was associated with less parental stress, less parental depression and anxiety, and milder maladaptive behavior in children. Both mothers with limited job flexibility and changes in the sleep rhythm of children were associated with reduced QOL of children and their parents. Low parental stress was associated with decreased maladaptive behavior in children and with maintained QOL of the family.Peer reviewe